Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Clotting Factors and Platelets – Beyond Hemostasis |
| Discussion Leader: Robert Montgomery (Blood Research Institute, Medical College of Wisconsin, USA) |
7:40 pm - 7:50 pm | Opening Remarks |
7:50 pm - 7:55 pm | Introduction by Discussion Leader |
7:55 pm - 8:20 pm | Shaun Jackson (Heart Research Institute, Australia) "Role of Procoagulant Platelets in Ischemia Reperfusion" |
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 8:50 pm | Eric Mullins (Cincinnati Children's Research Foundation, USA) "Role of Plasminogen in Neurodegenerative Diseases" |
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Peter Newman (Blood Research Institute, BloodCenter of Wisconsin, USA) "CRISPR-Mediated Generation of Antigenically-Distinct Platelet Progenitors from Human iPS Cells" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Factor VIII and Von Willebrand Factor:
Redefining the Relationship |
| Discussion Leader: James O'Donnell (Trinity College, Dublin, Ireland) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Andrew Yee (University of Michigan, USA) "Mapping the Interaction Between FVIII and VWF" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Peter Lenting (INSERM, France) "In Vivo Models to Study the VWF/FVIII Axis" |
10:10 am - 10:25 am | Discussion |
10:25 am - 10:55 am | Coffee Break |
10:55 am - 11:20 am | Karl Desch (University of Michigan, USA) "Genomic Approaches to VWF and FVIII Variability" |
11:20 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Paul Monahan (Baxalta, USA) "Curing Hemophilia B" |
12:00 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
3:00 pm - 4:00 pm | Power Hour |
| The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. |
| Organizer: Alisa Wolberg (University of North Carolina at Chapel Hill, USA) |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Megakaryocytes, Platelets and Cancer |
| Discussion Leader: Xiaoping Du (University of Illinois at Chicago, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:00 pm | Tatiana Byzova (Cleveland Clinic, USA) "Tumor Progression, Platelets and Angiogenesis" |
8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Herve Falet (Brigham and Women's Hospital, USA) "Endocytosis and
Mpl/JAK2 Signaling in Megakaryocytes and Myelofibrosis" |
8:40 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Myriam Labelle (St. Jude Children's Research Hospital, USA) "Platelets and the Early Metastatic Niche" |
9:20 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Inflammation and Hemostasis |
| Discussion Leader: Jose Lopez (Bloodworks Northwest Research Institute, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Alireza Rezaie (St. Louis University School of Medicine, USA) "Crosstalk of Proteases and Inflammation" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:10 am | X. Long Zheng (University of Alabama at Birmingham, USA) "Novel Therapeutics for
Autoimmune TTP" |
10:10 am - 10:25 am | Discussion |
10:25 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Keith McCrae (Cleveland Clinic, USA) "Hemostatic and
Non-Hemostatic Functions of High Molecular Weight Kininogen" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Edward Conway (Center for Blood Research, University of British Columbia, Canada) "Complement, Inflammation and the Clotting Cascade" |
11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Matthew Rondina (University of Utah, USA) "Platelet Reprogramming
in Sepsis" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Platelets and Clotting Factors in Normal Hemostasis |
| Discussion Leader: Peter Newman (Blood Research Institute, BloodCenter of Wisconsin, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:00 pm | Wolfgang Bergmeier (University of North Carolina at Chapel Hill, USA) "Putting the Brakes on Platelets" |
8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Rodney Camire (Children's Hospital of Philadelphia / University of Pennsylvania, USA) "Rediscovering Factor V" |
8:40 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Jordan Shavit (University of Michigan, USA) "Use of Zebrafish as a Model for Hemostasis" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Megakaryocytes, Platelets and the Bone Marrow Niche |
| Discussion Leader: Steven McKenzie (Thomas Jefferson University, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Paul Bray (Thomas Jefferson University, USA) "Plateletomics: Exploring
Platelet Biology via Multi-Omic Data Integration" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Karin Hoffmeister (Brigham and Women's Hospital / Harvard Medical School, USA) "The Molecular Mechanisms of Platelet Clearance" |
10:10 am - 10:25 am | Discussion |
10:25 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Benjamin Kile (Walter and Eliza Hall Institute for Medical Research, Australia) "The Role of Apoptosis in the Regulation of Platelet Survival and Function" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Joe Italiano (Brigham and Women's Hospital / Harvard University, USA) "Triggering Platelet Production" |
11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Alessandra Balduini (Tufts University, USA) "Scaffolds for Megakaryocyte Development" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Late-Breaking Topics |
| Speakers for Late-Breaking Topics were selected from submitted abstracts. |
| Discussion Leader: Alisa Wolberg (University of North Carolina at Chapel Hill, USA) |
7:30 pm - 7:40 pm | Joseph Aslan (Oregon Health and Science University, USA) "Deciphering Roles for Reversible Protein Lysine Acetylation in the Regulation of Platelet Function" |
7:40 pm - 7:45 pm | Discussion |
7:45 pm - 7:55 pm | Silvia Giannini (Brigham and Women's Hospital, USA) "JAK2 Regulates β4galt1-Dependent Glycan Synthesis on β1-Integrin to Promote Thrombopoiesis" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | Marco Heestermans (Leiden University Medical Center, The Netherlands) "Silencing of Anticoagulant Protein C Evokes Low Incident but Spontaneous Atherothrombosis in Apolipoprotein E Deficient Mice" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:25 pm | Lalitha Nayak (Case Western Reserve University, USA) "Myeloid Kruppel-Like Factor 2 (KLF2) Alters Tissue Factor Activity and Is a Critical Determinant of Arterial Thrombosis" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Dmitry Nechipurenko (Lomonosov Moscow State University, Russia) "Outward Migration of Procoagulant Platelets to Thrombus Surface Is Driven by Thrombus Contraction" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Jamie O'Sullivan (Trinity College, Dublin, Ireland) "N-Linked Glycans at N1515 and N1574 Within the A2 Domain of VWF Play a Critical Role in Modulating Macrophage-Mediated Clearance" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Claudia Tersteeg (KU Leuven Kulak, Belgium) "Endogenous Plasmin Activity in Acute Thrombotic Thrombocytopenic Purpura" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Sidney Whiteheart (University of Kentucky, USA) "Platelet Endocytosis in Immune Responses to Viral Infection" |
9:25 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Hemostasis and the Interface with the Vessel Wall |
| Discussion Leader: Skip Brass (University of Pennsylvania, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Keith Neeves (Colorado School of Mines, USA) "Magnetically Propelled
Microwheels for Rapid Fibrinolysis" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Renhao Li (Emory University, USA) "Platelet Mechanosensation: To Pull the Trigger, Not Cluster" |
10:10 am - 10:25 am | Discussion |
10:25 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Satya Kunapuli (Temple University, USA) "Platelet Signaling and the Vessel Wall" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Wilbur Lam (Emory University / Georgia Institute of Technology, USA) "Spatial and Mechanical
Cues of the Platelet Microenvironment and Their Roles in Clot Format" |
11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Matthew Auton (Mayo Clinic, USA) "Conformational Activation of VWF" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Session: New Therapies and Targets |
| Discussion Leader: Kenneth Mann (Haematologic Technologies, Inc., USA) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:20 pm | Denisa Wagner (Harvard Medical School, USA) "NETs in Thrombosis and Inflammation" |
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | J. Evan Sadler (Washington University in St. Louis, USA) "Von Willebrand Factor/ADAMTS13 and Their Role in Health and Disease" |
9:15 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |