Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Initiating Events in Hemostasis and Thrombosis
Discussion Leader: Hartmut Weiler (Blood Research Institute, BloodCenter of Wisconsin, USA)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
David Gailani (Vanderbilt University, USA)
"Initiation of Contact Activation"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Santiago Di Pietro (Colorado State University, USA)
"Mechanisms of Platelet Alpha and Dense Granule Biogenesis"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
James Morrissey (University of Michigan Medical School, USA)
"Contact Pathway Activation and Polyphosphate"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Contributions from the Blood and Vasculature
Discussion Leader: Usha Pendurthi (University of Texas Health Science Center at Tyler, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Charles Lowenstein (University of Rochester Medical Center, USA)
"Regulation of Endothelial Exocytosis"
9:30 am - 9:45 am
Discussion
9:45 am - 10:10 am
Douglas Fowler (University of Washington, USA)
"Making and Measuring the Effect of Mutations on a Massive Scale"
10:10 am - 10:25 am
Discussion
10:25 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:15 am
Elizabeth Gardiner (Australian National University, Australia)
"Fibrin/GPVI Interactions in Thrombosis and Hemostasis"
11:15 am - 11:30 am
Discussion
11:30 am - 11:55 am
Andreas Greinacher (Universitätsmedizin Greifswald, Germany)
"Combining Immunohematology and Biophysics to Better Understand Immune-Mediated Blood Cell Disorders: Lessons Learned from HIT"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Randal Westrick (Oakland University, USA)
"A Chromosome 5 Cis-Regulatory Element Regulates Mouse Platelet PAI-1 Expression"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Karen Vanhoorelbeke (KU Leuven, Belgium)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Molecular Interactions Between Blood and Platelets
Discussion Leader: David Lillicrap (Queen's University, Canada)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Jorge Di Paola (University of Colorado, USA)
"Role of Aging and Inflammation in Platelet Activation"
8:00 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Karen Vanhoorelbeke (KU Leuven, Belgium)
"Emerging Concepts in Immune-Mediated Thrombotic Thrombocytopenic Purpura"
8:40 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Judith Cosemans (Maastricht University, The Netherlands)
"Platelet/Fibrin Interactions During Thrombosis"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cellular Contributions to Hemostasis and Thrombosis
Discussion Leader: Gow Arepally (Duke University School of Medicine, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Jose Lopez (Bloodworks Northwest Research Institute, USA)
"Alterations in von Willebrand Factor and Redox State in Sickle Cell Disease"
9:30 am - 9:45 am
Discussion
9:45 am - 10:10 am
Evi Stavrou (Case Western Reserve University, USA)
"Zymogen Factor XII and Neutrophil Functions"
10:10 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Marvin Nieman (Case Western Reserve University, USA)
"The Dynamics of Protease Activated Receptor (PAR) Activation and Signaling"
11:15 am - 11:30 am
Discussion
11:30 am - 11:55 am
James O'Donnell (Royal College of Surgeons in Ireland, Ireland)
"Role of VWF Glycans in Regulating Clearance"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Kellie Machlus (Harvard Medical School, USA)
"Mechanisms of Altered Platelet Production During Inflammation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advanced Models of Coagulation
Discussion Leader: Owen McCarty (Oregon Health & Science University, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Bart van Vlijmen (Leiden University Medical Center, The Netherlands)
"Insights into the Pathophysiology of Thrombosis Using Mice with Impaired Anticoagulation"
8:00 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Scott Diamond (University of Pennsylvania, USA)
"Regulating Intra-Clot Thrombin and Fibrin Production Under Flow"
8:40 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Karin Leiderman (Colorado School of Mines, USA)
"Mathematical Models of Coagulation"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New and Emerging Therapeutic Targets
Discussion Leader: Maria Aleman (Bioverativ, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Roland Herzog (Indiana University, USA)
"Oral Therapy for Hemophilia"
9:30 am - 9:45 am
Discussion
9:45 am - 10:10 am
Umesh Desai (Virginia Commonwealth University, USA)
"Novel Anticoagulants Through Allosteric Regulation of Coagulation Proteases"
10:10 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Bruce Sullenger (Duke University, USA)
"Targeting FXa with Aptamer-Small Molecule Active Site Inhibitor Pairs for Potent and Reversible Anticoagulation"
11:15 am - 11:30 am
Discussion
11:30 am - 11:55 am
Gallia Levy (Genentech, USA)
"Assessing the Benefit of Emicizumab for the Treatment of Hemophilia A: From Lab to Label"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Ashley Brown (North Carolina State University / University of North Carolina at Chapel Hill, USA)
"Platelet-Like Particles for Hemostasis and Wound Repair"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Late-Breaking Topics
Discussion Leader: Alan Mast (BloodCenter of Wisconsin, USA)
7:30 pm - 7:40 pm
Selected from Poster Abstracts: Alison Banka (University of Michigan, USA)
"The Effect of Rigid Red Blood Cells on Platelet Margination and Adhesion in Flow"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Selected from Poster Abstracts: Jim Crawley (Imperial College London, United Kingdom)
"Crystal Structure and Allosteric Activation of ADAMTS13"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Selected from Poster Abstracts: DaShawn Hickman (Case Western Reserve University, USA)
"Design of Biomaterials-Based Technologies for Intravenous Mitigation of Trauma-Associated Hemorrhage and Coagulopathy"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Selected from Poster Abstracts: Mettine Bos (Leiden University Medical Center, The Netherlands)
"Uncovering the Unique Functional APC-Resistant Modifications of Pseudonaja textilis Factor V"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Selected from Poster Abstracts: Timothy Stalker (University of Pennsylvania, USA)
"Context Matters: Influence of the Physical Environment on the Spatial Distribution of Platelet Activation and Thrombin Activity During Hemostasis In Vivo "
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Selected from Poster Abstracts: Audrey Cleuren (University of Michigan, USA)
"In Vivo Transcriptional Profiling of the Endothelium in a Novel Mouse Model of von Willebrand Disease"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Selected from Poster Abstracts: Miguel Neves (St. Michael's Hospital / University of Toronto, Canada)
"Development of Novel Anti-Fouling Molecular Probes to Detect New Platelet Ligands and Pathogenic Anti-Platelet Antibodies"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Jeremy Wood (University of Kentucky, USA)
"BFPI: A Minimal Prothrombinase Inhibitor from the Saliva of Simulium vittatum "
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Coagulation Mechanisms Beyond Hemostasis
Discussion Leader: Andrew Weyrich (University of Utah School of Medicine, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Joseph Palumbo (Cincinnati Children's Hospital Medical Center, USA)
"Mechanisms Coupling Hemostatic Factors to Tumorigenesis"
9:30 am - 9:45 am
Discussion
9:45 am - 10:10 am
Mari Kaartinen (McGill University, Canada)
"The Role of Factor XIII-A in Energy Metabolism"
10:10 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Rafal Pawlinski (University of North Carolina at Chapel Hill, USA)
"Coagulation in Sickle Cell Disease"
11:15 am - 11:30 am
Discussion
11:30 am - 11:55 am
James Luyendyk (Michigan State University, USA)
"Role of Coagulation in Liver Injury and Repair"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Weifei Zhu (Cleveland Clinic Foundation, USA)
"The Anti-Thrombotic Effect of Aspirin Is Partially Transmissible via Gut Microbe Transplantation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Keynote Session: Hemostasis and Thrombosis: Bench to Bedside
Discussion Leader: Sidney Whiteheart (University of Kentucky, USA)
5:30 pm - 5:40 pm
Introduction by Discussion Leader
5:40 pm - 6:20 pm
Jeffrey Weitz (McMaster University, Canada)
"Antithrombotic Therapy: Today and Tomorrow"
6:20 pm - 6:35 pm
Discussion
6:35 pm - 7:15 pm
Rodger McEver (Oklahoma Medical Research Foundation, USA)
"Cellular Targets in Thrombosis"
7:15 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure