Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Coagulation: Signaling and Structure
Discussion Leader: Sriram Krishnaswamy (University of Pennyslvania, United States)
7:40 pm - 8:05 pm
JoAnn Trejo (University of California, San Diego, United States)
"Protease Receptor Signaling and Endothelial Function"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Jonas Emsley (University of Nottingham, United Kingdom)
"Contact Factor Structure and Assembly of the Contact Activation System"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Björn Dahlbäck (Lund University, Sweden)
"Protein S and Factor V as Synergistic TFPI Cofactors in the Regulation of Coagulation"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Coagulation and Platelets
Discussion Leaders: Edward Conway (University of British Columbia, Canada) and Cristina Puy (Oregon Health & Science University, United States)
9:00 am - 9:25 am
Martha Sola-Visner (Boston Children's Hospital, United States)
"Thrombocytopenia and Platelet Transfusions in Neonates: Less is More"
9:25 am - 9:40 am
Discussion
9:50 am - 10:15 am
Justin Hamilton (CSL, Australia)
"Toward Thrombosis-Specific Anti-Platelet Approaches via Class II PI3-Kinase Inhibition"
10:15 am - 10:30 am
Discussion
10:30 am - 10:55 am
Group Photo / Coffee Break
10:55 am - 11:20 am
Alisa Wolberg (University of North Carolina at Chapel Hill, United States)
"Mechanisms in Genetic and Acquired Bleeding"
11:20 am - 11:35 am
Discussion
11:35 am - 12:00 pm
A. Valance Washington (Oakland University, United States)
"Novel Insights Into Platelet Functionalization of Fibrinogen by The Triggering Receptor Expressed in Myeloid Cells (TREM) - Like Transcript (TLT)-1"
12:00 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Zhenyu Li (Texas A&M University, United States)
"Pyroptosis of Macrophages Drives DIC in Sepsis"
12:30 pm - 12:40 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Gow Arepally (Duke University School of Medicine, United States) and A. Valance Washington (Oakland University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Maintaining Hemostatic Balance
Discussion Leader: William Hobbs (Vertex Pharmaceuticals, United States)
7:30 pm - 7:55 pm
Marie-Christine Bouton (INSERM U1148, France)
"PN-1, a Unique Serpin in Thrombosis and Hemostasis"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Huanghe Yang (Duke University School of Medicine, United States)
"TMEM16F Phospholipid Scramblase in Hemostasis and Beyond"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
A. Koneti Rao (Lewis Katz School of Medicine at Temple University, United States)
"Diabetes Mellitus, Stroke and Tissue Factor Pathway of Blood Coagulation: Therapeutic Implications"
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Endothelium and Clotting
Discussion Leader: Heyu Ni (University of Toronto , Canada)
9:00 am - 9:25 am
John Hwa (Yale Medical School, United States)
"A New Platelet Novel: Rewriting a Story Without a Clot"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
Courtney Griffin (Oklahoma Medical Research Foundation, United States)
"Endothelial PARs in Thrombotic Diseases"
10:05 am - 10:20 am
Discussion
10:20 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Mark Kahn (University of Pennsylvania, United States)
"Spatial Regulation of Thrombosis in Vivo"
11:20 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Jim Crawley (Imperial College London, United Kingdom)
"The Molecular Basis of ADAMTS13 Function"
12:00 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Misuk Bae (Duquesne University School of Pharmacy, United States)
"Novel Peptide Nanoformulation that Inhibits Ga12/a-SNAP–dependent von Willebrand Factor Secretion for Reducing Thrombotic Complications in Sepsis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Lessons of Molecular Hemostasis from Organisms that Feed on Blood
Discussion Leader: Joshua Muia (Oklahoma State University Center for Health Sciences, United States)
7:30 pm - 7:55 pm
Mettine Bos (Leiden University Medical Center, The Netherlands)
"The Evolutionary Adaptation of Blood Coagulation Factors V and X in Snakes"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Ivo Francischetti (Johns Hopkins University School of Medicine, United States)
"How Tick Saliva Affects Hemostasis"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Diana Imhof (University of Bonn, Germany)
"Tridegin: An FXIII Inhibitor of the Giant Amazon Leech"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Coagulation and Platelets in Diseases
Discussion Leader: Ulhas Naik (Thomas Jefferson University, United States)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
Jill Johnsen (University of Washington, United States)
"Deep Mutational Scanning of Factor IX"
9:40 am - 9:55 am
Discussion
9:55 am - 10:20 am
Aaron Petrey (University of Utah, United States)
"Platelet Hyaluronidase-2 Regulates the Early Stages of Inflammatory Disease in Colitis"
10:20 am - 10:35 am
Discussion
10:35 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
Audrey Cleuren (Oklahoma Medical Research Foundation, United States)
"TRAPping Endothelial Cell Expression Profiles in Vivo"
11:35 am - 11:50 am
Discussion
11:50 am - 12:00 pm
John Kostyak (Jefferson University, United States)
"PLK3 Deletion Eliminates Bacteremia in an in vivo Model of Sepsis"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Frederik Denorme (University of Utah, United States)
"Expression of Human PAR4 in Novel Humanized Mouse Strains Supports PAR4 Thr120 Variant as Regulator of Platelet Hyperreactivity, Platelet-induced NET Formation and Ischemic Stroke Injury"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pm
Late-Breaking Topics
Discussion Leader: Gow Arepally (Duke University School of Medicine, United States)
7:30 pm - 7:40 pm
Wen Dai (Versiti Blood Center of Wisconsin, United States)
"Intracellular tPA-PAI-1 Interaction Determines apoB Lipidation and VLDL Assembly in Hepatocytes"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Lawrence Goldfinger (Thomas Jefferson University, United States)
"Plasma Growth Factors Drive Constitutive Translation in Circulating Platelets to Maintain Protein Homeostasis and Modulate Platelet Reactivity and the Hemostatic/Thrombotic Balance"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Harriet Allan (Queen Mary University London, United Kingdom)
"Platelet-Derived Mitochondria Alter Neutrophil Phenotype"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Xu Han (Case Western Reserve University, United States)
"A Mouse Model of Protease Activated Receptor 4 (PAR4) variant rs2227376 Has Reduced Platelet Reactivity to Physiological Doses of Thrombin"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Amy Siebert-McKenzie (Blood Research Institute, United States)
"Targeted Disruption of the Alpha Isoform of the Tissue Factor Pathway Inhibitor Gene Results in Complete Embryonic Lethality in Factor V Leiden Mice"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Joshua Lykins (University of Kentucky, United States)
"Packaging of Platelet Factor 4 by Megakaryocytes is Dependent on the Intracellular Proteoglycan, Serglycin, and Influences the Bone Marrow Microenvironment"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Molly Mollica (University of Washington, United States)
"Force Generation and Cytoskeletal Structure of Single Platelets"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Veronica DeYoung (McMaster University, Canada)
"Characterizing Protease-Resistant ADAMTS13 Mutants"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Bleeding and Clotting Control
Discussion Leader: Sanjana Dayal (University of Iowa, United States)
9:00 am - 9:25 am
Colin Kretz (McMaster University, Canada)
"Exploring the Regulation of ADAMTS13"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
Weikai Li (Washington University in St Louis, United States)
"Structural Basis of Vitamin K Antagonism"
10:05 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Lindsey George (CHOP/UPENN, United States)
"Exploiting FVIIIa Regulation for Therapeutic Benefit for Hemophilia A"
11:10 am - 11:25 am
Discussion
11:25 am - 11:50 am
Walter Kahr (University of Toronto, Canada)
"Megakaryocyte and Platelet Agranules: A Unique Lysosome-Related Organelle"
11:50 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Christopher Ng (University of Colorado - Anschutz Medical Campus, United States)
"Regulation of VWF Expression in Blood Outgrowth Endothelial Cells"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Keynote Session: Von Willebrand Factor and Kindlins in Bleeding Disorders
Session in memory of J. Evan Sadler
Discussion Leader: Gary Gilbert (Harvard Medical School, United States)
5:30 pm - 6:15 pm
Edward Plow (Cleveland Clinic, United States)
"Unexpected Functions of Kindlins in Blood and Vascular Cells"
6:15 pm - 6:30 pm
Discussion
6:30 pm - 7:00 pm
Robert Montgomery (Medical College of Wisconsin, United States)
"The Impact of Evan Sadler and New Discoveries of VWF Function"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Brooke Sadler (Washington University School of Medicine, United States)
"Characterization of CNVs in a Large Cohort of VWD Patients Reveals Relationship Between Disrupted Regions and Disease Type"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure