| Saturday |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Session: Exploring the Multiple Career Pathways in Blood Research |
| Discussion Leaders: Carleigh Hebbard (University of Illinois at Urbana-Champaign, USA) and Matthew Rondina (University of Utah, USA) |
| 3:45 pm - 4:20 pm | Jose Lopez (Bloodworks Northwest Research Institute, USA)
"Exploring the Multiple Career Pathways in Blood Research" |
| 4:20 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Novel Developments in Coagulation: Relevance to Therapeutics |
| Discussion Leaders: Laura Haynes (University of Vermont, USA) and Alisa Wolberg (University of North Carolina at Chapel Hill, USA) |
| 7:30 pm - 7:45 pm | Francis Ayombil (University of Vermont, USA)
"GPI-Anchored, Platelet-Derived Factor Va: Characterization of Its Total Resistance to Proteolytic Inactivation" |
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | James Byrnes (University of North Carolina at Chapel Hill, USA)
"The Interaction Between Fibrinogen and Zymogen FXIII-A2B2 Is Mediated by Fibrinogen Residues γ390-396 and the FXIII-B Subunits" |
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Adam Miszta (Maastricht University, The Netherlands)
"Thrombin-Dependent Incorporation of von Willebrand Factor into a Fibrin Network" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Jamie O'Sullivan (Trinity College, Dublin, Ireland)
"N-Linked Glycans at N1515 and N1574 Within the A2 Domain of VWF Play a Critical Role in Modulating Macrophage-Mediated Clearance" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Yuhang Zhou (Thomas Jefferson University, USA)
"TULA-2 Inhibits FcgammaRIIA-Syk Signaling Pathway and Heparin-Induced Thrombocytopenia in Mice" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Michel Smeets (Sanquin Research, The Netherlands)
"Platelet-Independent Binding of Erythrocytes to von Willebrand Factor" |
| 9:25 pm - 9:30 pm | Discussion |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Platelets, Megakaryocytes, and Their Function Beyond Hemostasis / Mentorship Component: Career Panel |
| Discussion Leaders: Karin Hoffmeister (Brigham and Women's Hospital / Harvard Medical School, USA) and Leila Noetzli (University of Colorado Denver, USA) |
| 9:00 am - 9:15 am | Caterina Casari (University of North Carolina at Chapel Hill, USA)
"Protein Kinase C Signaling Dysfunction in von Willebrand Disease Type 2B Platelets" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Marten Hansen (Sanquin Bloodbank, The Netherlands)
"Megakaryopoiesis from Induced Pluripotent Stem Cells: Gray Platelet Syndrome iPS Cell Differentiation Uncovers a Role for Gfi1b in Megakaryopoiesis and Endothelial Specification" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Kellie Machlus (Harvard Medical School, USA)
"Protein Degradation Through the Ubiquitin-Proteasome Pathway Is Necessary for Proplatelet Production" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Megan Rost (University of Michigan, USA)
"Nfe2 Is Dispensable for Early, but Required for Adult Thrombocyte Formation and Function in Zebrafish" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 11:00 am | Panel Discussion |
| "Careers in Science: Keys to Success" |
|
- Karin Hoffmeister (Brigham and Women's Hospital / Harvard Medical School, USA)
- John Kulman (Codiak Biosciences, USA)
- Jose Lopez (Bloodworks Northwest Research Institute, USA)
- Alisa Wolberg (University of North Carolina at Chapel Hill, USA)
|
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Hemostasis, Sepsis and Inflammation: Understanding Mechanisms of Disease |
| Discussion Leaders: Matthew Rondina (University of Utah, USA) and Frederik Denorme (KU Leuven Kulak, Belgium) |
| 1:30 pm - 1:45 pm | Julie Goswami (University of Pittsburgh Medical Center, USA)
"Innate Immune Response After Liver Ischemia/Reperfusion Promotes Distal Organ Injury Through Maintenance of a Pro-Coagulant State" |
| 1:45 pm - 1:50 pm | Discussion |
| 1:50 pm - 2:05 pm | Jessica Morales (University of Puerto Rico, Puerto Rico)
"Emerging Role for TLT-1 in the Interception Between Inflammatory Hemorrhage and Hemostasis" |
| 2:05 pm - 2:10 pm | Discussion |
| 2:10 pm - 2:25 pm | Julie Rayes (University of Birmingham, United Kingdom)
"CLEC-2 Deficient Platelets Modulate the Inflammatory Response Following Toxin-Mediated Inflammation in Mice" |
| 2:25 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
