| SUNDAY |
| 2:00-9:00 | Arrival & check-in |
| 6:00 | Dinner |
| Evening Session |
| Discussion Leader: Timothy Gallagher, University of Bristol |
| 7:20 - 7:30 | Greeting by GRC Chair and Staff |
| 7:30 - 8:00 | David Austin, Yale University
Synthetic Application of Transient Heteroatom-Liked Intramolecular Pauson-Khand Cyclizations |
| 8:00 - 8:10 | Discussion |
| 8:10 - 8:30 | Michael Kort, Abbott Laboratories
Benzotriazole-Mediated Synthesis of N-Acyl Aminal Derivatives |
| 8:30 - 8:40 | Discussion |
| 8:40 - 9:20 | James Panek, Boston University
Studies on the synthesis of complex natural products |
| 9:20 - 9:30 | Discussion |
| MONDAY |
| 7:30-8:30 | Breakfast |
| Morning Session 1 |
| Discussion Leader: Tim Jamison, Mass. Inst. of Technology |
| 8:45 - 9:35 | Rick Danheiser, Mass. Inst. of Technology
New Cycloaddition and Annulation Strategies for the Synthesis of Oxygen and Nitrogen Heterocycles |
| 9:35 - 9:45 | Discussion |
| 9:45 - 10:00 | Photograph |
| 10:00 -10:15 | Break |
| 10:15 -10:45 | Paul Devine, Merck Research Laboratories
"The Synthesis of Highly Substituted Triazolopyridazines" |
| 10:45 - 10:55 | Discussion |
| Morning Session 2 |
| Discussion Leader: George Sheppard, Abbott Laboratories |
| 10:55 - 11.25 | Zhihua Sui, Johnson & Johnson Pharmaceutical R&D
Synthesis of Pyrroloquinolones as PDE5 Inhibitors |
| 11:25-11:35 | Discussion |
| 11:35 - 12:15 | P. Andrew Evans, University of Indiana
Stereoselective Construction of Complex Polycyclic Ethers using New Cross-Coupling Reactions |
| 12:15 - 12:25 | Discussion |
| 12:30 | Lunch |
| 4:00 - 6:00 | Poster Session 1 |
| 6:00 | Dinner |
| Evening Session |
| Discussion Leader: Richard Hsung, University of Minnesota |
| 7:30 - 8:00 | Pauline Ting, Schering Plough Research
The Synthesis and Histamine 3 Activity of Novel 4-(1H- Imidazol-4-yl)piperidines
|
| 8:00 - 8:10 | Discussion |
| 8:10 - 8:30 | Elke Schoffers, Western Michigan U.
"Development of Chiral 1,10-Phenanthroline Derivatives as Novel Ligands" |
| 8:30 - 8:40 | Discussion |
| 8:40 - 9:20 | Tohru Oishi, Osaka University
Total Synthesis of Ciguatoxins |
| 9:20-9:30 | Discussion |
| TUESDAY |
| 7:30-8:30 | Breakfast |
| Morning Session 1 |
| Discussion Leader: William Lubell, University of Montreal |
| 8:45- 9:25 | Janine Cossy, ESPCI Paris
Methodologies and application to biologically active heterocyclic compounds |
| 9:25 - 9:35 | Discussion |
| 9:35 - 10:15 | Francois Terrier, University of Versailles
The multifaceted reactivity of nitrobenzofuroxans as superelectrophiles and Diels-Alder reagents |
| 10:15- 10:25 | Discussion |
| 10:25 - 10:50 | Break |
| Morning Session 2 |
| Discussion Leader: James Edwards, Johnson & Johnson |
| 10:50 -11:20 | Brian Stoltz, California Institute of Technology
Heterocycles in Synthesis and Catalysis |
| 11:20 - 11:30 | Discussion |
| 11:30 - 12:15 | David MacMillan, California Institute of Technology
Enantioselective Organocatalysis: A Valuable Strategy for Asymmetric Synthesis |
| 12:15 - 12:30 | Discussion |
| 12:30 | Lunch |
| 4:00 - 6:00 | Late Breaking News |
| 6:00 | Dinner |
| Evening Session |
| Discussion Leader: Stephen Bergmeier, Ohio University |
| 7:30 - 8:00 | Mark Schnute, Pharmacia
Non-nucleoside, Broad-Spectrum Antivirals against the Herpesvirus Family |
| 8:00 - 8:10 | Discussion |
| 8:10 - 8:30 | Shannon Stahl, University of Wisconsin
"Catalytic Oxidative Nitrogen Transfer to Olefins with Molecular Oxygen as the Stoichiometric Oxidant" |
| 8:30 - 8:40 | Discussion |
| 8:40 - 9:20 | Iwao Ojima, SUNY @ Stony Brook
New Cyclizations for the Syntheses of Heterocycles
|
| 9:20-9:30 | Discussion |
| WEDNESDAY |
| 7:30-8:30 | Breakfast |
| Morning Session 1 |
| Discussion Leader: Kay Brummond, U. of Pittsburgh |
| 8:45 - 9:00 | Michael Krische, U. of Texas
Catalytic Cycloreductions, Cycloadditions and Cycloisomerizations: Enones as Latent Enolates |
| 9:00 - 9:10 | Discussion |
| 9:10 - 9:25 | Andrei Yudin, U. of Toronto
Electrochemical Aziridination of Olefins |
| 9:25 - 9:35 | Discussion |
| 9:35 - 10:05 | John Montgomery, Wayne State University
Nickel-Catalysis in the Total Synthesis of Heterocyclic Natural Products |
| 10:05- 10:15 | Discussion |
| 10:15 - 10:40 | Break |
| Morning Session 2 |
| Discussion Leader: Norma Tom, Pfizer Groton |
| 10:40 -11:10 | Karin Briner, Lilly Research Laboratories
The Synthesis of Heteroaryl Piperazines and Piperidines as Selective 5-HT2C Receptor Agonists for the Treatment of Obesity |
| 11:10 - 11:20 | Discussion |
| 11:20 - 12:10 | Jose Barluenga, University of Oviedo
The Synthesis of nitrogenated heterocycles through Fischer Carbene complexes |
| 12:10 - 12:25 | Discussion |
| 12:30 | Lunch |
| 4:00 - 6:00 | Poster Session 2 |
| 6:00 | Dinner |
| Evening Session |
| Discussion Leader: Brad Henke, Glaxo Smithkline |
| 7:30 - 8:00 | Dennis Yamashita, Glaxo SmithKline
Heterocyclic Inhibitors of the Osteoclast-specific Cysteine Protease, Cathepsin K |
| 8:00 - 8:10 | Discussion |
| 8:10 - 8:30 | Tomislav Rovis, Colorado State University
"A Highly Enantioselective Catalytic Intramolecular Stetter Reaction" |
| 8:30 - 8:40 | Discussion |
| 8:40 - 9:20 | Erick Carreira, ETH Zurich
New strategies and Methods for Asymmetric Synthesis. |
| 9:20 - 9:30 | Discussion |
| THURSDAY |
| 7:30-8:30 | Breakfast |
| Morning Session 1 |
| Discussion Leader: Jeffrey Johnson, U. of North Carolina |
| 8:45 - 9:25 | James Cook, University of Wisconsin-Milwaukee
General Approach for the Synthesis of Indole Alkaloids via the Asymmetric Pictet -Spengler reaction |
| 9:25 - 9:35 | Discussion |
| 9:35 - 10:05 | John A. Porco, Jr., Boston University
Synthesis of Bioactive Natural Products Using C-N and C-O Bond Construction |
| 10:05- 10:15 | Discussion |
| 10:15 - 10:40 | Break |
| Morning Session 2 |
| Discussion Leader: Joseph Konopelski, U. C. Santa Cruz |
| 10:40 -11:10 | John Tellew, Bristol Myers Squibb
The Synthesis and SAR of Heterocyclic Biphenylsulfonamides as Single Molecule Dual GPCR Receptor Antagonists |
| 11:10 - 11:20 | Discussion |
| 11:20 - 12:10 | Daniel Comins, North Carolina State University
Enantiopure Dihydropyridones as Synthetic Intermediates |
| 12:10 - 12:25 | Discussion |
| 12:30 | Lunch |
| 4:00 - 6:00 | Reception |
| 6:00 | Dinner |
| Evening Session |
| Discussion Leader: Edward C.Taylor, Princeton University |
| 7:30-8:00 | Bruce Lipshutz, University of California at Santa Barbara
"Coenzyme Q10: We Make It...and We Take It" |
| 8:00 - 8:10 | Discussion |
| 8:10 - 9:00 | Harry Wasserman, Yale University
Chemistry of tricarbonyls and related systems; Applications in the synthesis of bioactive compounds |
| 9:00 - 9:15 | Discussion |
| Vice Chairs Comments |
