| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | BIOLOGICALLY SIGNIFICANT HETEROCYCLES I |
| Discussion Leader: Huw Davies (SUNY Buffalo) |
| 7:30 pm - 8:05 pm | Ohyun Kwon (University of California at Los Angeles)
"Phosphine-Catalyzed Annulations and Their Applications in Diversity-Oriented Synthesis (DOS) and Target-Oriented Synthesis (TOS)" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:55 pm | Dennis Liotta (Emory University)
"New Therapies for Viral Infections and Cancers" |
| 8:55 pm - 9:05 pm | Discussion |
| 9:05 pm - dusk | Fireworks in Newport |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | STRUCTURAL DIVERSITY IN HETEROCYCLIC CHEMISTRY |
| Discussion Leader: Brad Henke (GlaxoSmithKline) |
| 9:00 am - 9:40 am | Tomas Hudlicky (Brock University)
"Synthesis of Natural and Unnatural Amaryllidaceae and Morphine Alkaloids: Toward Practical Syntheses" |
| 9:40 am - 9:50 am | Discussion |
| 9:50 am - 10:40 am | Photograph and Break |
| 10:40 am - 11:20 am | Prabhakar K. Jadhav (Eli Lilly & Company)
"Discovery of Potent Heterocyclic Ligands for Steroid Nuclear Hormone Receptors"
|
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:10 pm | Richard Taylor (University of York)
"Adventures in Natural Product Synthesis" |
| 12:10 pm - 12:20 pm | Discussion |
| 12:30 pm | Lunch |
| 1:00 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 1 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | BIOLOGICALLY SIGNIFICANT HETEROCYCLES II |
| Discussion Leader: John Macor (Bristol-Myers Squibb) |
| 7:30 pm - 8:00 pm | Marlon Cowart (Abbott)
"Building Better CNS Drugs through Heterocyclic Chemistry. Cognitive-Enhancing H3 Antagonists" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:30 pm | Sherry Chemler (SUNY Buffalo)
"Concise Heterocycle Synthesis Via Copper(II) Acetate Promoted Intramolecular Aminocarbonation and Diamination of Olefins" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:20 pm | Peter Wipf (University of Pittsburgh)
"Synthetic Approaches to PI3 Kinase Inhibitors" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ADVANCES IN HETEROCYCLIC COMPOUND SYNTHESIS |
| Discussion Leader: Karin Briner (Eli Lilly) |
| 9:00 am - 9:35 am | Phil Baran (The Scripps Research Institute)
"The Catalytic Cycle of Discovery in Total Synthesis" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:20 am | Dan Yang (University of Hong Kong)
"Explorations on Radical and Non-radical Cyclization Reactions" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Break |
| Discussion Leader: Elke Schoffers (Western Michigan University) |
| 11:00 am - 11:30 am | Michael Willis (University of Bath)
"Tandem Palladium Catalysis: New Routes to Indoles and Benzofurans" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:20 pm | David Hart (The Ohio State University)
"Cyclization Reactions: Approaches to Selected Natural Products" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:00 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 7:35 pm | Conference Business - Nominations for 2006 Chair |
| 7:35 pm - 9:30 pm | ASSEMBLY OF COMPLEX HETEROCYCLES |
| Discussion Leader: Glenn Micalizio (Yale University) |
| 7:35 pm - 8:00 pm | Mark Macielag (Johnson and Johnson PRD)
"New Tactics and Strategies for the Design and Synthesis of Macrolide Antibiotics" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:35 pm | Dave Laffan (AstraZeneca)
"Synthesis, Scale-Up and Manufacture of Rosuvastatin Calcium (Crestor)" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:20 pm | Dale Boger (The Scripps Research Institute)
"Yatakemycin: Synthetic and Mechanistic Studies" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CATALYSIS IN HETEROCYCLIC SYNTHESIS |
| Discussion Leader: Angela Kerekes (Schering-Plough) |
| 9:00 am - 9.40 am | Kay Brummond (University of Pittsburgh)
"A Diverging Strategy for Accessing Multiple Architecturally Unique Compounds From a Pivotal Substrate" |
| 9:40 am - 9:50 am | Discussion |
| 9:50 am - 10:20 am | Zhiguo Jake Song (Merck and Co.)
"Efficient Asymmetric Synthesis of a Drug Candidate and Discovery of New Processes" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Break |
| Discussion Leader: Jetze Tepe (Michigan State University) |
| 11:00 am - 11:30 am | Robert Hughes (Pfizer)
"Process Research Towards an Efficient Synthesis of an EGFR Tyrosine Kinase Inhibitor" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:20 pm | Masakatsu Shibasaki (University of Tokyo)
"Catalytic Asymmetric Synthesis of Biologically Significant Heterocycles" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | SYNTHETIC STRATEGIES FOR COMPLEX HETEROCYCLES |
| Discussion Leader: Wayne Vaccaro (Bristol-Myers Squibb) |
| 7:30 pm - 8:00 pm | Robert Stockman (University of East Anglia)
"Combining Two-Directional Synthesis and Tandem Reactions: Developing Efficient Strategies for Alkaloid Synthesis" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:35 pm | Derek Denhart (Bristol-Myers Squibb)
"Novel conformationally-restricted homotryptamines as short-acting SSRIs" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:20 pm | Jim Leighton (Columbia University)
"Strained Silacycles: A Powerful Platform for Asymmetric and Tandem Reaction Design" |
| 9:20 pm - 9:30 pm | Discussion |
| 9:30 pm - 11:30 pm | Poster Session 2 |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | SYNTHESIS AND MECHANISM |
| Discussion Leader: Melanie Sanford (University of Michigan) |
| 9:00 am - 9:35 am | Matt Sigman (University of Utah)
"Aerobic Oxidations in Organic Synthesis" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:20 am | Kristjan Gudmundsson (GlaxoSmithKline)
"Synthesis of Pyrazolopyridines, Imidazopyridines and Related Heterocycles as Antiherpetics" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Conference Business: Election of 2006 Chair / Break |
| Discussion Leader: Gregory Dake (University of British Columbia)
|
| 11:00 am - 11:30 am | Celia Dominguez (Amgen)
"p38 MAPK inhibitors: Chemistry, Research and Discovery of AMG 548" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:20 pm | Dalibor Sames (Columbia University)
"C-H Bond Functionalization in Organic Synthesis: Direct and Systematic Elaboration of Heterocyclic Motifs" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Reception |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | STRUCTURAL DIVERSITY IN HETEROCYCLIC CHEMISTRY |
| Discussion Leader: Thomas Goodwin (Hendrix College) |
| 7:30 pm - 8:05 pm | Jonathan Sessler (University of Texas at Austin)
"Synthesis and Applications of Oligopyrrole Macrocycles" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 9:10 pm | Paul Wender (Stanford University)
"New reactions, step economy and function oriented synthesis" |
| 9:10 pm - 9:20 pm | Discussion |
| 9:20 pm | Huw Davies (University of Buffalo)
Vice-chair's comments |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
