SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
5:00 pm - 6:00 pm | Welcome Mixer |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff and Conference Chair, Chris Moody |
7:30 pm - 9:30 pm | NEW METHODOLOGY IN THE SYNTHESIS OF HETEROCYCLIC COMPOUNDS I |
| Discussion Leader: J. Ramon Vargas (Eastman Kodak) |
7:40 pm - 8:25 pm | Jeffrey Aubé (University of Kansas) "Heterocyclic libraries inspired by natural products and peptides" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:20 pm | Viresh Rawal (University of Chicago) "Recent progress on the total synthesis of indole alkaloids" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | CATALYSIS IN HETEROCYCLIC CHEMISTRY |
| Discussion Leader: Julia M. Clay (Eli Lilly) |
9:00 am - 9:50 am | Gregory C. Fu (Massachusetts Institute of Technology) "Palladium- and nickel-catalyzed coupling reactions" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break / Group Photo (10:15 am) |
10:30 am - 11:00 am | Janis Louie (University of Utah) "Insights into Ni-catalyzed pyridine formation" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Tom G. Driver (University of Illinois at Chicago) "Transition metal-catalyzed reactions of azides" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Helena Malinakova (University of Kansas) "Transition metal-catalyzed multi-component coupling reactions and reaction sequences for the synthesis of medicinally relevant heterocycles" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 1 (Convenor: Ramon Vargas) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | SYNTHESIS OF HETEROCYCLIC NATURAL PRODUCTS |
| Discussion Leader: Tom Pettus (UC Santa Barbara) |
7:30 pm - 8:00 pm | Richmond Sarpong (University of California, Berkeley) "A unified strategy for the total synthesis of "miscellaneous" Lycopodium alkaloids" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 9:10 pm | Samuel J. Danishefsky (Columbia University/Sloan Kettering Institute) "Biologic level molecules through chemical synthesis" |
9:10 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NEW ROUTES TO BIOLOGICALLY ACTIVE HETEROCYCLES I |
| Discussion Leader: Jon Njardarson (Cornell University) |
9:00 am - 9:30 am | John Gilday (AstraZeneca) "Identification and development of manufacturing routes to the anilinoquinazoline, gefitinib, active ingredient of Iressa®" |
9:30 am - 9:35 am | Discussion |
9:35 am - 10:20 am | Mercedes Álvarez (IRB, Barcelona) "Synthesis of polyheterocyclic nitrogen containing marine natural products" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Kevin W. Gillman (Bristol Myers Squibb) "Heterocyclic gamma-secretase inhibitors for the treatment of Alzheimer’s disease" |
11:30 am - 11:35 am | Discussion |
11:35 am - 12:20 pm | Louis Barriault (University of Ottawa) "Harvest in the pericyclic reaction garden" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | HETEROCYCLIC NATURAL PRODUCTS AND THEIR BIOSYNTHESIS |
| Discussion Leader: George Sheppard (Abbott) |
7:30 pm - 8:00 pm | Sarah E. O’Connor (Massachusetts Institute of Technology) "Metabolic reprograming of alkaloid biosynthesis" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Craig A. Hutton (University of Melbourne) "Recent progress in the synthesis of cyclic peptide natural products" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 9:20 pm | Robert M. Williams (Colorado State University) "Total synthesis as a vehicle for penetrating biomechanistic puzzles: challenges in heterocyclic natural products chemistry" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NEW STRATEGIES TOWARDS HETEROCYCLIC COMPOUNDS |
| Discussion Leader: H. Ila (Indian Institute of Technology, Kanpur) |
9:00 am - 9:30 am | Anna Mapp (University of Michigan) "Small molecule transcriptional switches" |
9:30 am - 9:35 am | Discussion |
9:35 am - 10:20 am | Thorsten Bach (Technische Universität, Munich) "Heterocycles in photochemical and organometallic reactions" |
10:20 am - 10:30 am | Discussion |
10:30 am - 10:40 am | Business Meeting Part 1 |
| (Nominations for the next Vice Chair) |
10:40 am | Coffee Break |
11:10 am - 11:30 am | Neil Garg (UCLA) "Studies in heterocycle synthesis: indoles, indolines, and indolynes" |
11:30 am - 11:35 am | Discussion |
11:35 am - 12:20 pm | Donald Craig (Imperial College, London) "From aziridines to alkaloids: method development and total synthesis" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 2 (Convenor: Ramon Vargas) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | NEW METHODOLOGY IN THE SYNTHESIS OF HETEROCYCLIC COMPOUNDS II |
| Discussion Leader: Jennifer Love (University of British Columbia) |
7:30 pm - 8:00 pm | Paul Vogt (SiGNa) "Application of stabilized alkali metals in heterocyclic synthesis" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | James P. Stambuli (Ohio State University) "Nickel-catalyzed synthesis of oxazoles via C-S activation" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 9:20 pm | Sam Zard (École Polytechnique, Paris) "Adventures in radical chemistry: some unusual routes to heterocycles" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NEW ROUTES TO BIOLOGICALLY ACTIVE HETEROCYCLES II |
| Discussion Leader: Dan Elbaum (FoldRx Pharmaceuticals) |
9:00 am - 9:25 am | Brian Shook (Johnson & Johnson) "The design and Synthesis of indenopyrimidines as dual adenosine A2a/A1 antagonists for the treatment of Parkinson's disease" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | R. Jason Herr (Albany Molecular Research Inc) "Small adventures in total synthesis" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Business Meeting Part 2 |
| (Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Tehshik P. Yoon (University of Wisconsin, Madison) "Cycloadditions by visible light photocatalysis" |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Amy Dounay (Pfizer Global R&D) "Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as norepinephrine reuptake inhibitors and 5-HT1A partial agonists" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:25 pm | Scott Coffey (Eli Lilly) "Process development of an NK-1 antagonist" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time / Optional Wine Tasting Social (4:00 pm - 6:00 pm) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | PERSPECTIVES ON HETEROCYCLIC CHEMISTRY |
| The challenges posed by the synthesis of complex heterocyclic compounds |
| Discussion Leader: Chris Moody (University of Nottingham) |
7:30 am - 8:15 pm | Jon Rainier (University of Utah) "Approaches to heterocycles at 4700 feet above sea level" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 9:05 pm | Stephen F. Martin (University of Texas, Austin) "Recent advances in the synthesis of complex heterocyclic natural products" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:30 pm | J. Ramon Vargas (Eastman Kodak) "Vice Chair’s Closing Remarks" |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |