Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
New Methods for the Synthesis of Heterocyclic Compounds
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:05 pm
"Total Synthesis of Neurologically Active Natural Products"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"StackPhos: Using Chiral Heterocycles as Ligands to Make Chiral Amines"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
"Metal-Catalyzed Cross-Couplings of Alkyl Electrophiles"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Catalysis Towards Heterocyclic Systems
9:00 am - 9:20 am
"Oxidopyrylium-Alkene [5+2] Cycloadditions: A Superb Platform for Training Next Generation Scientists"
9:20 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Decarbonylative Transformation of Aromatic Esters and Multi-Arylation of Arenes"
9:55 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 11:05 am
"Boron-Heteroatom Addition Reactions"
11:05 am - 11:15 am
Discussion
11:15 am - 11:50 am
"Predictive Reaction Modeling Using Machine Learning"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synthesis of Heterocyclic Natural Products
7:30 pm - 7:55 pm
"Iron(III)-Catalyzed Carbonyl-Olefin Metathesis"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:35 pm
"Recent Studies in Alkaloid Synthesis"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
"Chemical Synthesis of Complex Molecules Featuring Heterocycles"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Synthetic Strategies, Heterocyclic Tools, and Isolation of Heterocyclic Natural Products
9:00 am - 9:30 am
"Polycyclic Diterpene Synthesis via Tandem Gold Catalysis"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Dearomative Functionalization with Arenophiles"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Organocatalytic Approaches to C-H Functionalization"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Discovery and Synthesis of Dipeptoid-Triazine Ligands for Protein Affinity Purification"
11:35 am - 11:45 am
Discussion
11:45 am - 12:20 pm
"Marine Natural Products. Chemically Diverse Alkaloids from the Ocean"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Optimization of Routes to Biologically Active Heterocycles
7:30 pm - 7:50 pm
"Process Research and Development of the Commercial Synthesis of BTK Inhibitor GDC-0853"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Chemistry Innovation – The Driver for Process Research and Development"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Flow Chemistry Solutions to Challenging Synthesis Problems"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Challenges in the Synthesis and Scale-Up of Phosphorous and Sulfur Containing Heterocycles"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Design and Synthesis of Biologically Active Heterocyclic Compounds
9:00 am - 9:25 am
"Development of a Large Scale Process for a p38 Kinase Inhibitor"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Functionalizing Heterocycles: Synthesis of β-Heteroaryl-α-Methyl-β-Amino Acids"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
"Building Fused Triazoles by Dipolar Cycloaddition Reactions Enables the Synthesis and Scaling of Novel P2X7 Antagonists"
11:10 am - 11:20 am
Discussion
11:20 am - 11:50 am
"Chiral Cyclic Sulfamidates and Their Utility in AZ Oncology Drug Discovery Projects"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
New Strategies to Construct Heterocyclic Compounds
7:30 pm - 7:55 pm
"Transition Metal-Catalyzed Amination Reactions"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:35 pm
"Formation of Ring-Fused Heterocycles via Strategic Ring-Opening Cyclizations"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
"Studies on Synthesis of Indole Alkaloids"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Heterocycles as Probes for Studying Biology and Human Disease
9:00 am - 9:25 am
"Near-IR Uncaging Chemistry: Discovery and Applications"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Synthesis Inspires Design: The Importance of Synthetic Innovations in Drug Discovery and Development"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 10:55 am
"Synthesis of Diverse Medium-Sized Oxygen Heterocycles via Oxidative Rearrangement of Simple Alcohols"
10:55 am - 11:00 am
Discussion
11:00 am - 11:35 am
"Silvestrol: The Good, the Bad and the Ugly"
11:35 am - 11:45 am
Discussion
11:45 am - 12:20 pm
"Heterocyclic Tool Compounds for Manipulating Biological Processes"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: An Outlook on Heterocyclic Chemistry
7:30 pm - 7:45 pm
"Selective Functionalization of Pyridines and Diazines via Heterocyclic Phosphonium Salts"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:25 pm
"Properties and Applications of Heterocycles in Medicinal Chemistry"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:10 pm
"Catalyst-Controlled Glycosylation Reactions"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure