Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
The Connectivity Between Methodology Development and Total Synthesis
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
"From Synthesis to Therapeutic Application: Making Heterocycles Great Again"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Photocatalytic Oxidation Reactions"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Improvements to the Synthesis of Heterocyclic Compounds
9:00 am - 9:35 am
"Sulfamate Esters Guide Atom-Transfer Processes"
9:35 am - 9:45 am
Discussion
9:45 am - 10:00 am
"N-Doped Carbon-Supported Cobalt Nanoparticle Catalysis for Oxidation Reactions Based on Polymer Incarceration Methods"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
"Chemoselective, Stereocontrolled Cu-Catalyzed C-N Couplings Towards a Highly Potent mPI3Ka Inhibitor"
11:10 am - 11:20 am
Discussion
11:20 am - 12:00 pm
"Bioactive Natural Products and New Reactions to Prepare Them: The Symbiotic Loop"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Unique Applications of Heterocycles to Broad Biology Challenges
7:30 pm - 8:05 pm
"Discovery and Development of PET Tracers for Neuroscience"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Tryptophan-Derived Probes for Studying the Kynurenine Pathway"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
"Roles of CDK8/19 in Oncology"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Development of Methodology for Improved Heterocyclic Synthesis
9:00 am - 9:30 am
"C-H and C-O Functionalization via Radical Chaperones"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Discovery and Synthesis of Triazolopyridines as Potent and Selective AMPAR γ8-TARP Negative Modulators"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"An Electrocatalytic Approach to New Reaction Discovery"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Synthesis of Highly Functionalized N-Alkyl 2-Pyridones and Indolizines"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Use of Novel Approaches to the Synthesis of Biologically Active Compounds
7:30 pm - 8:05 pm
"Exploratory Process Development of a Second Generation Beta-Amyloid Cleaving Enzyme (BACE1) Inhibitor"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Discovery and Optimization of Novel Dopamine Receptor Modulators for the Treatment of CNS Disorders"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Synthesis of a Highly Functionalized Octahydro-Isoindole-Based NK1 Receptor Antagonist"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Heterocycles and Their Use as Biological Probes
9:00 am - 9:30 am
"New Reactions of Indole for Enabling Synthesis and Biology"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Reaction Cascades for Heterocycle Synthesis"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Natural Product Synthesis"
11:20 am - 11:30 am
Discussion
11:30 am - 12:05 pm
"Total Synthesis of Complex Natural Products"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
The Use of Heterocycles in Catalysis
7:30 pm - 8:05 pm
"Heterocycle Synthesis for the Treatment of Pain, Cystic Fibrosis and Hepatitis C"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Leveraging Metal Carbenes for Assembling Complexity"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Redox Catalysis Strategies for Complex Molecules"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Strategies for the Synthesis of Heterocycles
9:00 am - 9:35 am
9:35 am - 9:45 am
Discussion
9:45 am - 10:20 am
"Deciphering the Gut Microbiota with Chemistry"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:35 am
"Discovery and Synthesis of PF-6821497, a Potent EZH2 Inhibitor"
11:35 am - 11:45 am
Discussion
11:45 am - 12:20 pm
"New Synthetic Opportunities with Alkenyl Nitrones and Hydroxylamines"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Nature Inspired Synthesis of Heterocyclic Natural Products
7:30 pm - 8:15 pm
"Translational Chemistry"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 9:10 pm
"Inspired by Molecular Structure and the Challenge of Doing Chemistry on Strong C-H Bonds"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure