Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Heterocycles Inspiring Creativity in Organic Synthesis
7:40 pm - 8:15 pm
"Synthesis Through C–C Bond Scission"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
Short Talk Selected from Poster Abstracts
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
"Simple-Looking but Non-Obvious Transformations"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Exploring Heterocycles as Bioactive Molecules
9:00 am - 9:30 am
"Advances in Agrochemical Discovery at FMC"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Redox-Economic Alkaloid Synthesis"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Discovery of Rinvoq® (Upadacitinib): A Potent and Selective Jak1 Inhibitor"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Orforglipron: Development of a Convergent Synthesis of a Complex Heterocycle"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Heterocycles as Inspiration for Synthesis
7:30 pm - 8:00 pm
"Evolution of a Concise Approach to Chiral Cyclohexyl Based Drug Candidate BMS-986278 (Admilparant)"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Triazole-Based Enantioselective Anion-Binding Catalysis: From the Design to Synthetic Applications"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Attempts to Deliver on the Promise of Natural Products"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Methodology and Heterocycle Synthesis
9:00 am - 9:30 am
"New Methods Using A-Carbonyl Sulfoxonium Ylides to Achieve Heterocycles"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Boron Trihalides as Versatile Reagents in Synthetic Strategy"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Short Talk Selected from Poster Abstracts
11:05 am - 11:10 am
Discussion
11:10 am - 11:40 am
"Engaging Undergraduates in Organic Chemistry to Diversify the Field"
11:40 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"A General Platform for the Synthesis of Organofluorine Compounds"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Complex Heterocycle Discovery and Assembly
7:30 pm - 8:00 pm
"Unexpected Heterocyclic Alkaloids from Millipede Secretions"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Building Bonds with Boron"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Heterocycles: Where Would I Be Without Them!"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Synthesis of Heterocyclic Compounds
9:00 am - 9:30 am
"Development of Efficient Routes to 6-Aryl Picolinate Herbicides"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Small Ring Heterocycles as Mediators for Catalytic Asymmetric Dearomatization"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"The Evolution of Synthesis: From Research to Development"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Sustainable Strategies for Synthesizing Heterocyclic Drug Substances at Boehringer"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Catalysis and Heterocyclic Compound Synthesis
7:30 pm - 8:00 pm
"Development of a Continuous Process to the Pyridine Core of SAR443820"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"High-Throughput Experimentation: A Catalyst for Innovation Across Drug Modalities and Development Stages"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Functionalized Heterocycles Derived from Carbon Dioxide Enabled by Catalysis"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Heterocycle Synthesis and Design
9:00 am - 9:30 am
"Heterocyclics in Dyes and Conducting Polymeric Materials"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Mining Peptide Macrocycles in the Plant Kingdom"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Short Talk Selected from Poster Abstracts
11:05 am - 11:10 am
Discussion
11:10 am - 11:40 am
"Switching the Immune System Off and On Through Computationally Enabled Drug Discovery and the Discovery of HPK1 Inhibitor NDI-101150 for Cancer"
11:40 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Building Efficient, Diastereo- and Enantioselective Synthetic Routes to Trans-Cyclopropyl Esters for Rapid Lead Scale-Up"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Transformative Power of Heterocycles
7:30 pm - 8:15 pm
"A Mechanism-Driven Predictive Model for the Catalyst-Controlled Asymmetric Rh(I)-Catalyzed Pauson–Khand Reaction"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
"New Aspects of Chiral Brønsted Acid and Base Catalysis"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure