SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Introductory Comments by GRC Site Staff / Chair's Welcome by Lisa Marcaurelle (H3 Biomedicine) |
7:40 pm - 9:30 pm | Frontiers in Chemical Biology |
| Discussion Leader: Paul Hanson (University of Kansas) |
7:40 pm - 8:05 pm | Emily Balskus (Harvard University)
"Gut Reactions: Understanding Disease-Associated Chemistry from the Human Microbiota" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Jennifer Prescher (University of California, Irvine)
"Expanding the bioluminescent toolkit" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:25 pm | Andrew Phillips (Yale University)
"Synthetic chemistry and mass-spectrometry: opportunities for impacting novel therapeutics" |
9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:30 am | Rapid Assembly of Complex Molecules |
| Discussion Leader: Jacqueline Wurst (Broad Institute) |
9:00 am - 9:25 am | Sarah Reisman (California Institute of Technology)
"The Development of New Synthetic Methods for the Rapid Construction of Molecular Complexity" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Yujiro Hayashi (Tohoku University)
"One-pot reactions in total synthesis" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 12:30 pm | Phenotypic Screening and Chemical Proteomics |
| Discussion Leader: Peter Fekkes (H3 Biomedicine) |
10:30 am - 10:55 am | Matthew Boxer (NIH/NCATS)
"Phenotypic Screen Identifies Potent Inhibitors of Lipid Droplet Formation" |
10:55 am - 11:00 am | Discussion |
11:00 am - 11:25 am | Sam Gerritz (Bristol-Myers Squibb)
"Small Molecules that Inhibit Influenza Virus Replication via Formation of Nucleoprotein Oligomers" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Lyn Jones (Pfizer)
"Target engagement using chemical proteomics" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:25 pm | Ivan Cornella-Taracido (Sanofi)
"Industrial Chemical Biology - hype or hope?" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Synthesis and Chemical Biology of Natural Products |
| Discussion Leader: Joshua Pierce (North Carolina State University) |
7:30 pm - 7:55 pm | Jiyong Hong (Duke University)
"Natural Product Synthesis at the Interface of Chemistry and Biology" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:30 pm | Derek Tan (Memorial Sloan-Kettering Cancer Institute)
"Natural Product-based Strategies in Diversity-Oriented Synthesis" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 9:25 pm | Dale Boger (Scripps Research Institute)
"Redesign of Vancomycin for Resistant Bacteria" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:40 am | Cheminformatics |
| Discussion Leader: Donovan Chin (Novartis) |
9:00 am - 9:25 am | Meir Glick (Novartis)
"Perturbanomics: emergent discoveries from HTS Fingerprints of compounds or siRNA" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Andrew Hopkins (University of Dundee)
"Encoding the creativity and beauty of drug design" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:40 am | Group Photo / Coffee Break |
10:40 am - 12:30 pm | Library Design, Synthesis and Screening |
| Discussion Leader: Aaron Beeler (Boston University) |
10:40 am - 11:05 am | Adam Nelson (University of Leeds)
"Towards the Systematic Exploration of Chemical Space" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Andrei Yudin (University of Toronto)
"High-Throughput Synthesis Enabled by Amphoteric Molecules" |
11:35 am - 11:40 am | Discussion |
11:40 am - 12:00 pm | Stefan Gradl (Chiromics)
"Organocascade Catalysis: A new synthetic strategy is taking Affinity Screening Mass Spectrometry to the next level" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:25 pm | Melvin Yu (Eisai)
"Application of Statistical Modeling to Library Building" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Integrated Chemical-Biological Approaches |
| Discussion Leader: Craig Thomas (NIH/NCATS) |
7:30 pm - 7:45 pm | 2011 Poster Winner: Albert Bowers (University of North Carolina, Chapel Hill)
"Bacterially-Encoded, Post-Translationally Modified Peptidomimetics for Drug Discovery" |
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 8:05 pm | 2011 Poster Winner: Leslie Ofori (Stanford University)
"Strategies for sequence-selective RNA recognition"
|
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | M.G. Finn (Georgia Institute of Technology)
"Function is All that Matters: Adventures in Target-Guided Assembly" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:25 pm | Herbert Waldman (Max Plank Institute)
"Small molecule inhibition of KRas-Signaling - A systems approach" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:30 am | New Approaches to Anti-Infective Drug Discovery |
| Discussion Leader: Paul Fleming (AstraZeneca) |
9:00 am - 9:25 am | Jared Shaw (University of California, Davis)
"Studies in Bacterial Cell Biology En Route to New Antibiotics" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Jeremy Duvall (Broad Institute)
"Role of Next-Generation Synthesis in Anti-Infective Drug Discovery" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 12:30 pm | Case Studies in Parallel Medicinal Chemistry |
| Discussion Leader: Kevin Woller (AbbVie) |
10:30 am - 10:55 am | Christopher Helal (Pfizer)
"Application of High-Speed Synthesis for the Identification of Sub-type Selective, Brain Penetrant, Phosphodiesterase Inhibitors" |
10:55 am - 11:00 am | Discussion |
11:00 am - 11:25 am | Zhi-Cai Shi (Merck)
"Accelerating the Discovery of DGAT1 inhibitors Through High Throughput Synthesis and Purification" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Rene Lemieux (Agios)
"Optimization and Characterization of Mutant IDH Inhibitors for the Treatment of Cancer" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:25 pm | David Maloney (NIH/NCATS)
"Discovery of ML323, A Potent and Selective Inhibitor of the USP1/UAF1 Deubiquitinase Complex" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | New Platforms for Reaction Discovery and Optimization |
| Discussion Leader: Corey Stephenson (Boston University) |
7:30 pm - 8:05 pm | Tim Jamison (Massachusetts Institute of Technology)
"Continuous Multistep Synthesis" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:45 pm | Spencer Dreher (Merck)
"Micro-scale high-throughput chemistry: enabling modern chemistry in real-world synthesis" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:25 pm | John Hartwig (University of California, Berkeley)
"High Throughput Experimentation for Catalyst Discovery, Development, and Application" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:30 am | New Catalytic Methods for Synthesis |
| Discussion Leader: Alessandra Bartolozzi (Boehringer Ingelheim) |
9:00 am - 9:25 am | Abigail Doyle (Princeton University)
"Design of New Transition Metal-Catalyzed Synthetic Methods" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Thomas Nielsen (Technical University of Denmark)
"Synthesis of Heterocycles through Metal-Catalyzed Isomerization Reactions" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 12:30 pm | Small Molecule Modulation of Gene Expression |
| Discussion Leader: Ann Rowley (Infinity Pharmaceuticals) |
10:30 am - 10:55 am | James Bradner (Dana Farber Cancer Institute)
"Chemical Control of Chromatin Structure and Function" |
10:55 am - 11:00 am | Discussion |
11:00 am - 11:25 am | Richard Cummings (Constellation Pharmaceuticals)
"Translating chromatin modulation into drug discovery: EZH2" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Richard Chesworth (Epizyme)
"Drug Discovery and Histone Methyl Transferases" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:25 pm | Stefan Kubicek (CeMM Research Center for Molecular Medicine)
"Chemical Epigenetics - Small molecule modulators of cell fate" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | The Science of Therapeutics |
| Discussion Leader: Mike Foley (Broad Institute) |
7:30 pm - 7:40 pm | Closing remarks by Lisa Marcaurelle (H3 Biomedicine) and Scott Wolkenberg (Merck) |
7:40 pm - 8:20 pm | Markus Warmuth (H3 Biomedicine)
"Translating the Cancer Genome into Therapeutics: Key Challenges and Hurdles" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:20 pm | Stuart Schreiber (Harvard University)
"Human Biology, Chemical Biology and the Science of Therapeutics" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |