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High Throughput Chemistry and Chemical Biology

Gordon Research Conference

New Modalities, Methods and Mechanisms for Chemical Biology

June 25 - 30, 2017
Chairs Andrew J. Phillips
Vice Chair Ivan Cornella-Taracido
Proctor Academy
204 Main Street
Andover, New Hampshire, United States
 Venue and Travel Information

Conference Description

Dear Colleagues

The 2017 High-Throughput Chemistry and Chemical Biology (HTCCB) Gordon Research Conference, carries forward the torch of cutting-edge science at the ever-evolving interface of chemistry and chemical biology. The 2017 edition will be held at the Proctor Academy in Andover, NH and will gather invited speakers and attendees from industry, academia and other research institutions for collegial and dynamic discussions of the latest methods, modalities, and mechanisms from chemistry and their use to impact chemistry, chemical biology, and medicine. Afternoon poster sessions will also contribute to the scientific and social exchange at the HTCCB GRC and all conferees are encouraged to participate through the presentation of a poster.

Betsy Parkinson (University of Illinois at Urbana-Champaign) and Cynthia Chio (University of California, San Francisco) are organizing the 5th Gordon Research Seminar (GRS) on High-Throughput Chemistry and Chemical Biology. This GRS will be held on Saturday and Sunday June 13-14, immediately prior to the GRC and will provide an opportunity for trainees to share science and interact with leading researchers in an intimate setting. Graduate students and post-docs are encouraged to apply to both the GRS and GRC.

We invite you to apply to what we expect will be an exciting, stimulating, and memorable meeting.

Andy Phillips, C4 Therapeutics and Ivan Cornella-Taracido, Merck and Co.
Chair and Vice-Chair, 2017 GRC on High-Throughput Chemistry and Chemical Biology

Related Meeting

This GRC will be held in conjunction with the "High Throughput Chemistry and Chemical Biology" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: The Vanguard of Chemical Biology
Discussion Leader: Jennifer Prescher (University of California, Irvine, USA)
7:40 pm - 8:10 pm
Randy Peterson (Massachusetts General Hospital / Harvard University, USA)
"Behavior-Based Discovery of New Optochemical Genetic Tools"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
Daria Hazuda (Merck Research Laboratories, USA)
"Novel Approaches to Infectious Disease Targets"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:25 pm
Dirk Trauner (New York University, USA)
"Optical Control of the Cytoskeleton"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Small Molecule Probes, Drug Candidates and New Approaches in Chemical Biology
Discussion Leader: Betsy Parkinson (University of Illinois at Urbana-Champaign, USA)
9:00 am - 9:30 am
Anna Mapp (University of Michigan, USA)
"Small Molecule Modulators of Conformationally Dynamic Protein Complexes"
9:30 am - 9:35 am
Discussion
9:35 am - 10:05 am
Richard Sparks (Incyte Corporation, USA)
"Fragment to Pharmacophore to Candidate: Invention of INCB054329, a Potent and Selective BRD Inhibitor in Clinical Trials for Oncology"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Jonathan Morris (University of New South Wales, Australia)
"Developing Small Molecule Inhibitors of RNA Splicing Kinases for the Modulation of Protein Isoforms"
10:40 am - 10:45 am
Discussion
10:45 am - 11:15 am
Coffee Break
11:15 am - 11:45 am
Emily Balskus (Harvard University, USA)
"Deciphering the Human Microbiome Using Chemistry"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Benjamin Spangler (Novartis Institutes for Biomedical Research, USA)
"Molecular Probes for Determination of Sub-Cellular Compound Exposure in Gram-Negative Bacteria"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Justin Rettenmaier (Whitehead Institute for Biological Research, USA)
"DELs in Cells: Phenotypic Screening with DNA-Encoded Cyclic Peptides"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chemical Biology with Proteins, Mini-Proteins, and Peptides
Discussion Leader: Joshua Kritzer (Tufts University, USA)
7:30 pm - 8:05 pm
Albert Bowers (UNC Eshelman School of Pharmacy, USA)
"Chemoenzymatic Platforms for the Discovery of New Peptide Therapeutics"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:45 pm
Brad Pentelute (Massachusetts Institute of Technology, USA)
"Homogenous Antibody Drug Conjugates Enabled by Cysteine Arylation"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:25 pm
Alan Saghatelian (Salk Institute for Biological Studies, USA)
"Discovery and Characterization of Novel Microproteins"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Novel Chemistries and Methods for Chemical Biology and Therapeutics
Discussion Leader: Aaron Wright (Pacific Northwest National Laboratory, USA)
9:00 am - 9:30 am
Marcus Bantscheff (Cellzome / GlaxoSmithKline, Germany)
"Comprehensive Drug Target Profiling Using Complementary (Chemo-)proteomics Approaches"
9:30 am - 9:35 am
Discussion
9:35 am - 10:05 am
Emily Parker (Victoria University of Wellington, New Zealand)
"Unravelling and (Re)engineering Biosynthetic Pathways"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Jennifer Prescher (University of California, Irvine, USA)
"Spying on Cellular Communication"
10:40 am - 10:45 am
Discussion
10:45 am - 11:15 am
Coffee Break
11:15 am - 11:30 am
Alison Narayan (University of Michigan, USA)
"Biocatalysis for Complex Molecule Synthesis"
11:30 am - 11:35 am
Discussion
11:35 am - 11:50 am
Shigeki Kiyonaka (Kyoto University, Japan)
"Chemogenetic Approach for Allosteric Activation of Neurotransmitter Receptors on Living Cells"
11:50 am - 11:55 am
Discussion
11:55 am - 12:25 pm
Corey Nislow (Genetic Networks, USA)
"The Cellular Response to Drugs Quantified by Fitness Profiling: A Genetic Networks' Perspective"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chemical Biology: Phenotype, Target Engagement, and Mechanism of Action
Discussion Leader: Cynthia Chio (University of California, San Francisco, USA)
7:30 pm - 8:05 pm
Stewart Fisher (C4 Therapeutics, Inc., USA)
"It's About Time: Mechanistic PK-PD Models for Time-Dependent Inhibitors"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:45 pm
Lyn Jones (Jnana Therapeutics, USA)
"Drug-Target Engagement in Live Cells"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:25 pm
Christopher Vakoc (Cold Spring Harbor Laboratory, USA)
"Generating Resistance Alleles of Epigenetic Drug Targets"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Chemistries and Methods for Chemical Biology and High-Throughput Experimentation
Discussion Leader: Samuel Gerritz (Bristol-Myers Squibb, USA)
9:00 am - 9:30 am
Stevan Djuric (AbbVie, USA)
"Enabling Chemistry Technologies - Accelerators of Drug Discovery"
9:30 am - 9:35 am
Discussion
9:35 am - 10:05 am
Alexander Satz (Roche, Switzerland)
"Design and Application of DNA Encoded Libraries at Roche"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Melodie Christensen (Merck, USA)
"High Throughput Experimentation in the Optimization of Metallaphotoredox Catalyzed Alpha-Hydroxy Arylation Reactions"
10:40 am - 10:45 am
Discussion
10:45 am - 11:20 am
Coffee Break
11:20 am - 11:50 am
Aleksandra Baranczak (AbbVie, USA)
"Approaches to Cellular Characterization of Small Molecule Protein Binders"
11:50 am - 11:55 am
Discussion
11:55 am - 12:25 pm
Anthony Keefe (X-Chem Pharmaceuticals, USA)
"Drug Discovery for Challenging Targets Using DNA-Encoded Chemistry"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Chemistry and Biology of Natural Products
Discussion Leader: Tarek Sammakia (University of Colorado Boulder, USA)
7:30 pm - 8:05 pm
Corinna Schindler (University of Michigan, USA)
"New Methods for the Synthesis of Biologically Active Molecules"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:45 pm
Michael Burkart (University of California, San Diego, USA)
"Directing Biosynthesis Through Protein-Protein Interactions"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:25 pm
Corey Stephenson (University of Michigan, USA)
"Redox Catalysis for Complex Molecule Synthesis"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Bivalent Molecules and Other Novel Approaches to Control of Function
Discussion Leader: Lyn Jones (Jnana Therapeutics, USA)
9:00 am - 9:30 am
Jingwen Zhang (AstraZeneca, USA)
"Clinical Candidate AZD5153 Is a Novel Bivalent Inhibitor of BET Bromodomains"
9:30 am - 9:35 am
Discussion
9:35 am - 10:05 am
Rhamy Zeid (C4 Therapeutics, USA)
"Targeted Protein Degradation as a Novel Therapeutic Approach"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
David Spiegel (Yale University, USA)
"Bifunctional Molecules for Modulating Human Immune Responses"
10:40 am - 10:45 am
Discussion
10:45 am - 11:20 am
Coffee Break
11:20 am - 11:50 am
Yimon Aye (Cornell University / Weill Cornell Medicine, USA)
"'Stay on Target' — Targeting Kinetically Privileged First Responders in Electrophile Signaling"
11:50 am - 11:55 am
Discussion
11:55 am - 12:25 pm
M.G. Finn (Georgia Institute of Technology, USA)
"Low Throughput Studies of Reactivity to Enable High Throughput Applications"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Novel Therapeutics
Discussion Leader: Alan Saghatelian (Salk Institute for Biological Studies, USA)
7:30 pm - 8:05 pm
Phil Chamberlain (Celgene, USA)
"Expanding the Druggable Genome with Cereblon Modulators"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:45 pm
Nathanael Gray (Dana Farber Cancer Institute, USA)
"Targeting Transcription Addiction in Cancer"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:25 pm
Steve Haggarty (Harvard Medical School / Massachusetts General Hospital, USA)
"Probing Neurogenetic Disorders Using Patient-Specific Stem Cells and Chemogenomics"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure

Contributors

Conference Links

Conference History High Throughput Chemistry and Chemical Biology (GRS)
Additional Fee Info

Bioorganic Chemistry
June 15 - 20, 2025
Heterocyclic Compounds
June 22 - 27, 2025
High Throughput Chemistry and Chemical Biology (GRS)
July 26 - 27, 2025
Natural Products and Bioactive Compounds
July 27 - August 1, 2025
Natural Products and Bioactive Compounds
July 28 - August 2, 2024


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