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High Throughput Chemistry and Chemical Biology (GRS)

Gordon Research Seminar

Synthetic Methodology and Enabling Technologies for Chemical Biology

June 18 - 19, 2011
Chairs and
Colby-Sawyer College
541 Main Street
New London, New Hampshire, United States
 Venue and Travel Information

Conference Description

The Gordon Research Seminar on High Throughput Chemistry & Chemical Biology is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The fields of high throughput chemistry and chemical biology employ the vast resources of synthetic, medicinal, biological and analytical chemistry for interrogating biological function and rapidly generating structural and functional information for combating disease. This year’s meeting will focus on exciting advances in these fields including parallel and combinatorial library design, screening technologies, protein targets and their role in disease, biological probes and new chemical tools with a focus towards drug discovery and understanding biological activity.

Related Meeting

This GRS will be held in conjunction with the "High Throughput Chemistry and Chemical Biology" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

SATURDAY
1:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by William Pomerantz (University of Michigan)
3:45 pm - 4:30 pmIntroductory Session: Keynote Speaker
3:45 pm - 4:15 pmJames A. Wells (UCSF)
"Site-directed Fragment Discovery for Challenging Targets"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmHigh-Throughput and Structure-Based Design Approaches towards Small Molecule Bioactives
Discussion Leaders: Joe Salvino (Alliance Discoveries) and Jiayue Cui (CTCMLD, University of Chicago)
7:30 pm - 7:50 pm Dina Fomina-Yadlin (Harvard)
"Small-molecule inducers of insulin expression in pancreatic alpha cells"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Martin Walsh (NIH, NCGC)
"Evaluation of 2-oxo-1,2,3,4-tetrahydroquinoline-6-sulfonamides as Activators of the Tumor Cell Specific M2 Isoform of Human Pyruvate Kinase"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Marco Schmidt (University of Cambridge)
"Towards the development of druglike Mycobacterium tuberculosis type II dehydroquinase (DHQ2) inhibitors via the discovery of dehydroquinate mimetics by fragment-based approaches"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Jun Wang (University of Pennsylvania)
"Structure-Based Design of Inhibitors Targeting Influenza A Virus M2 Proton Channel (A/M2)"
9:20 pm - 9:30 pm Discussion
SUNDAY
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amChemical Biology Approaches and New Technologies for Drug Discovery
Discussion Leaders: Sam Gerritz (Bristol-Myer-Squibb) and Victoria Rojo (University of Cambridge)
9:00 am - 9:20 am Raymond Moellering (Scripps)
"Targeting Protein-Protein and Protein-DNA Complexes with Stabilized Alpha-Helical Peptides"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Jun Qi (Dana-Farber Cancer Institute)
"Selective inhibition of BET bromodomains"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 am Matt O'Brien (University of Cambridge)
"Gas-Liquid Flow Chemistry Using Permeable Membranes"
10:20 am - 10:30 am Discussion
10:30 am - 10:50 am Mingyan Zhu (Seoul National University)
"Discovery of Novel Benzopyranyl Tetracycles that Act as Inhibitors of Osteoclastogenesis Induced by RANKL"
10:50 am - 11:00 am Discussion
11:00 am - 12:30 pmPoster Session II
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:00 pmChemoinformatic Tools for Drug Discovery
Discussion Leaders: Anand Singh (Sanford-Burnham Institute) and Malliga Iyer (NIH)
1:30 pm - 1:50 pm Jens Carlsson (UCSF)
"Structure-based discovery of GPCR ligands"
1:50 pm - 2:00 pm Discussion
2:00 pm - 2:30 pmCareer Development Panel
Panelists: Lisa Marcaurelle (Broad), Sam Gerritz (BMS), Alan Rolfe (University of Kansas), Tehshik Yoon (University of Wisconsin-Madison)
2:30 pm - 3:00 pmEvaluation Period
Fill out GRS Evaluation Forms
3:00 pmGordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm.

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Conference History High Throughput Chemistry and Chemical Biology
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