| SATURDAY |
| 1:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by William Pomerantz (University of Michigan) |
| 3:45 pm - 4:30 pm | Introductory Session: Keynote Speaker |
| 3:45 pm - 4:15 pm | James A. Wells (UCSF)
"Site-directed Fragment Discovery for Challenging Targets" |
| 4:15 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | High-Throughput and Structure-Based Design Approaches towards Small Molecule Bioactives |
| Discussion Leaders: Joe Salvino (Alliance Discoveries) and Jiayue Cui (CTCMLD, University of Chicago) |
| 7:30 pm - 7:50 pm | Dina Fomina-Yadlin (Harvard)
"Small-molecule inducers of insulin expression in pancreatic alpha cells" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Martin Walsh (NIH, NCGC)
"Evaluation of 2-oxo-1,2,3,4-tetrahydroquinoline-6-sulfonamides as Activators of the Tumor Cell Specific M2 Isoform of Human Pyruvate Kinase" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Marco Schmidt (University of Cambridge)
"Towards the development of druglike Mycobacterium tuberculosis type II dehydroquinase (DHQ2) inhibitors via the discovery of dehydroquinate mimetics by fragment-based approaches" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Jun Wang (University of Pennsylvania)
"Structure-Based Design of Inhibitors Targeting Influenza A Virus M2 Proton Channel (A/M2)" |
| 9:20 pm - 9:30 pm | Discussion |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Chemical Biology Approaches and New Technologies for Drug Discovery |
| Discussion Leaders: Sam Gerritz (Bristol-Myer-Squibb) and Victoria Rojo (University of Cambridge) |
| 9:00 am - 9:20 am | Raymond Moellering (Scripps)
"Targeting Protein-Protein and Protein-DNA Complexes with Stabilized Alpha-Helical Peptides" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Jun Qi (Dana-Farber Cancer Institute)
"Selective inhibition of BET bromodomains" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Matt O'Brien (University of Cambridge)
"Gas-Liquid Flow Chemistry Using Permeable Membranes" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Mingyan Zhu (Seoul National University)
"Discovery of Novel Benzopyranyl Tetracycles that Act as Inhibitors of Osteoclastogenesis Induced by RANKL" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:00 pm | Chemoinformatic Tools for Drug Discovery |
| Discussion Leaders: Anand Singh (Sanford-Burnham Institute) and Malliga Iyer (NIH) |
| 1:30 pm - 1:50 pm | Jens Carlsson (UCSF)
"Structure-based discovery of GPCR ligands" |
| 1:50 pm - 2:00 pm | Discussion |
| 2:00 pm - 2:30 pm | Career Development Panel |
| Panelists: Lisa Marcaurelle (Broad), Sam Gerritz (BMS), Alan Rolfe (University of Kansas), Tehshik Yoon (University of Wisconsin-Madison) |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill out GRS Evaluation Forms |
| 3:00 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |
