| SATURDAY |
| 1:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Session |
| 3:45 pm - 4:15 pm | Andrew Phillips (Yale)
"Chemistry. Biology. Therapeutics. Building a Shared Future in Chemical Biology" |
| 4:15 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Synthetic Chemistry Development Toward Novel Leads |
| Discussion Leader: Tatiana Pilyugina (Broad Institute) |
| 7:30 pm - 7:48 pm | Christopher White (University of Toronto)
"Synthesis and Reactivity of Aziridine-2-Carboxylic Acid Containing Cyclic Peptides"
|
| 7:48 pm - 7:54 pm | Discussion |
| 7:54 pm - 8:12 pm | Mette Ishoey (Technical University of Denmark)
"Synthesis of Heterocycles via Ru-Catalyzed Tandem RCM/Isomerization Sequences"
|
| 8:12 pm - 8:18 pm | Discussion |
| 8:18 pm - 8:36 pm | Peyton Shieh (University of California Berkeley)
"Development of Long-Wavelength Fluorogenic Azides for Biological Imaging"
|
| 8:36 pm - 8:42 pm | Discussion |
| 8:42 pm - 9:00 pm | Elizabeth Parkinson (University of Illinois Urbana-Champaign)
"Efficient NQO1 Substrates are Potent and Selective Anticancer Agents"
|
| 9:00 pm - 9:06 pm | Discussion |
| 9:06 pm - 9:24 pm | Todd Wenderski (Memorial Sloan-Kettering Cancer Center)
"Biomimetic Diversity-Oriented Synthesis of Benzannulated Medium Rings via Ring Expansion"
|
| 9:24 pm - 9:30 pm | Discussion |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Advances in Strategies for Therapeutic Discovery |
| Discussion Leader: Renato Bauer (Harvard University) |
| 9:00 am - 9:18 am | Anne Wassermann (Novartis Institutes for Biomedical Research)
"Applications of HTS-Fingerprints in Hit Finding and Lead Discovery"
|
| 9:18 am - 9:24 am | Discussion |
| 9:24 am - 9:42 am | Darci Trader (Indiana University)
"Development and Application of Reversible Enrichment Tags for Natural Product Discovery"
|
| 9:42 am - 9:48 am | Discussion |
| 9:48 am - 10:06 am | Christopher Stratton (Albert Einstein College of Medicine)
"Diversity-Oriented Synthesis of Macrocycles using Oxidative Ring Expansion Reactions"
|
| 10:06 am - 10:12 am | Discussion |
| 10:12 am - 10:30 am | Justin Rettenmaier (University of California San Francisco)
"Targeting a General Kinase Regulatory Mechanism: Allosteric Effectors of PDK1"
|
| 10:30 am - 10:36 am | Discussion |
| 10:36 am - 10:54 am | Leslie Ofori (Stanford University)
"Sequence Specific RNA Recognition by Small Molecules with Application to Myotonic Distrophy and HIV"
|
| 10:54 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Career Development Panel |
| Panelists:
- Lisa Marcaurelle (H3 Biomedicine)
- Scott Wolkenberg (Merck)
- Paul Hanson (University of Kansas)
- Anthony Bishop (Amherst College)
|
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill out GRS Evaluation Forms |
| 3:00 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |
