Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Advances in Chemical Biology
Discussion Leader: Elizabeth Parkinson (University of Illinois at Urbana-Champaign, USA)
3:45 pm - 4:25 pm
Emily Balskus (Harvard University, USA)
"Deciphering the Human Microbiome with Chemistry"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advances in Compound Library Design, Generation, and Utilization
Discussion Leader: Sarah Tasker (University of Illinois at Urbana-Champaign, USA)
7:30 pm - 7:45 pm
Camille Villequey (École Polytechnique Fédérale de Lausanne (EPFL), Switzerland)
"Expanding Chemical and Structural Diversity of Phage-Encoded Macrocyclic Peptide Libraries"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Naoko Ichiishi (Merck & Co., Inc., USA)
"Use of High Throughput Experimentation to Develop Enabling Late Stage Functionalization Approaches for Chemical Biology Applications"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Jon Bogart (University of North Carolina at Chapel Hill, USA)
"A Chemoenzymatic Platform for the Discovery of Thiopeptide Therapeutics"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Alix Chan (Harvard University, USA)
"Discovery of Bioactive Small Molecules from a DNA-Encoded Library x Library Selection"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Carlos Moreno-Yruela (University of Copenhagen, Denmark)
"Interrogating Substrate Specificity of Human Histone Deacetylases Using Peptide Microarrays"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Development of Chemical Probes and Therapeutics
Discussion Leader: Justin Rettenmaier (Whitehead Institute for Biological Research, USA)
9:00 am - 9:15 am
Juliane Totzke (Duke University, USA)
"EDHS-206, a Potent and Selective Inhibitor of TAK1, Targets Pro Survival TNFa Dependent Signaling, Inducing Apoptosis in Rheumatoid Arthritis and Breast Cancer Models"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Zachary Hill (University of California, San Francisco, USA)
"Probing the Ligandable Surface of PTP1B Through Tethering-Based Ligand Scanning"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Markus Lakemeyer (Technical University of Munich, Germany)
"Probing the Oligomeric Assembly and Catalytic Activity of S. aureus ClpP Using Small Molecules"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Chunyan Ren (Icahn School of Medicine at Mount Sinai, USA)
"Structural-Based Design of Epigenetic Chemical Modulators for CBX7 Chromodomain"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Denise Field (Pfizer, USA)
"Selective Downregulation of JAK2 and JAK3 by an ATP-Competitive Pan-JAK Inhibitor"
10:35 am - 10:40 am
Discussion
10:40 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Assays for Novel Target Identification
Discussion Leader: Evijola Llabani (University of Illinois at Urbana-Champaign, USA)
1:30 pm - 1:45 pm
Dylan Mitchell (University of Michigan, USA)
"Leveraging a Novel Activity-Based Probe for the Identification of 4E-BP1 Kinases"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Jonathan Shrimp (National Cancer Institute, NIH, USA)
"CRISPR-Cas9 Profiling of Lysine Acetyltransferase Activity"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:30 pm
General Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
