Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Expanding the Druggable Proteome
Discussion Leader: George Burslem (Yale University, USA)
3:45 pm - 4:20 pm
Benjamin Cravatt (The Scripps Research Institute, USA)
"Activity-Based Proteomics: Protein and Ligand Discovery on a Global Scale"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Screening Technologies in Chemical Biology
Discussion Leader: Ross Cheloha (Boston Children's Hospital / Harvard Medical School, USA)
7:30 pm - 7:45 pm
Bo Peng (University of Michigan, USA)
"Tailored Activity-Based Probes for Profiling Candidate Depalmitoylases"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
Jiankun Lyu (University of California, San Francisco, USA)
"Ultra-Large Library Docking for Discovering New Chemotypes"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
Amber Hackler (The Scripps Research Institute, USA)
"Off-DNA Affinity Screening of DNA-Encoded Libraries"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
Alice Herneisen (Whitehead Institute for Biomedical Research, Massachusettes Institute of Technology, USA)
"Using Thermal Proteome Profiling to Identify the Molecular Components of Calcium Signaling and Homeostasis in Apicomplexan Parasites"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Chemical Editing of Nucleic Acids and Proteins / Mentorship Component: Research in Academia, Industry and Government Agencies
Discussion Leaders: Khuchtumur Bum-Erdene (Indiana University School of Medicine, USA) and Chang He (University of Illinois at Urbana-Champaign, USA)
9:00 am - 9:15 am
Kellie Nance (National Cancer Institute, NIH, USA)
"N4-Acetylcytidine Alters Stability and Function of RNA"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Claire Munier (AstraZeneca, Sweden)
"Small Molecule Stabilization of the GR 14-3-3 Protein-Protein Interaction (PPI)"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Jonas Drechsel (Technische Universität München, Germany)
"A Chemical Probe to Monitor the Parkinsonism-Associated Protein DJ-1 in Live Cells"
9:55 am - 10:00 am
Discussion
10:00 am - 11:00 am
Panel Discussion
Research in Academia, Industry and Government Agencies
Ivan Cornella-Taracido (Cedilla Therapeutics, USA)
Ann Rowley (AbbVie, USA)
Benjamin Cravatt (The Scripps Research Institute, USA)
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Advances in Synthetic Chemistry and Drug Development
Discussion Leader: David Cardoso (University of Sydney, Australia)
1:30 pm - 1:45 pm
M. Cynthia Martin (AbbVie, USA)
"An Alternative and Accurate Approach for Sub-Milligram Solid Dispensing for Practical High-Throughput Experimentation"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Adam Green (University of Leeds, United Kingdom)
"Progress Towards the Autonomous Discovery of New p53/hMDM2 PPI Inhibitors"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
Fathima Thanzeel (Georgetown University, USA)
"Asymmetric Reaction Screening with a Molecular Click Chemistry Sensor"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes