Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Technology and Platform Development
Discussion Leader: Robin Krystufek (Institute of Organic Chemistry and Biochemistry AS CR, Czech Republic)
3:45 pm - 4:20 pm
Petra Dittrich (ETH Zurich, Switzerland)
"High-Density Droplet Arrays for High Throughput Analysis"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advances in Chemistry and High-Throughput Synthesis + Career Discussion Panel
Discussion Leader: John Burdick (UCI - Paegel Laboratory, United States)
7:30 pm - 7:45 pm
Xiao Qian Ng (National University of Singapore; Institute of Sustainability for Chemicals, Energy and Environment , Singapore)
"Synthesis of Aliphatic Amines Using Borrowing Hydrogen and its Application to Large-Scale Drug Synthesis"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Cassandra Kennedy (The Francis Crick Institute, United Kingdom)
"High Throughput Chemistry for Direct to Biology screening against Bacterial E3 Ligases"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Julian Götz (ETH Zürich, Switzerland)
"Miniaturized, Predictable, On-Demand Synthesis of Vast Libraries of Drug-Like Molecules"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 9:30 pm
Panel Discussion
Career Panel Discussion
Jennifer Heemstra (Washington University in St. Louis, United States)
Nessa Carson (AstraZeneca, United Kingdom)
Jordan Reddel (Dow Chemical, United States)
Mark Fitzgerald (Nested Therapeutics, United States)
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Hot Targets and Novel Discovery Approaches
Discussion Leader: Tong Lan (University of Chicago, United States)
9:00 am - 9:15 am
Huda Barhoosh (University of California Irvine, United States)
"Activity-Based DEL Screening: Expanding the Druggable Proteome Through Selective Modulation of Translation"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Bhaskar Chatterjee (University of Michigan, United States)
"FICD Inhibitors: Discovery, Development and Validation"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Katherine McPhie (The Francis Crick Institute, United Kingdom)
"Chemical Biology Approaches to Explore the Ligandability of TRIM E3 Ligases"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Leslie Spitalny (University of California, Irvine , United States)
"A General Fluorescence-Based Assay Measuring Compound Accumulation in Cells"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Amanda Nguyen (University of California, Irvine, United States)
"Activity-Based Aptamer Screening"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Tessa Epstein (University of Michigan, United States)
"Integrated High Throughput Synthesis and Screening Enable Discovery of Dynamic Protein Modulators"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Omics's and AI - Cheminformatics, Machine Learning, and High-throughput Analysis
Discussion Leader: Giulia Murbach-Oliveira (Purdue University, United States)
1:30 pm - 1:45 pm
Samuel Thompson (Stanford, United States)
"Developing Design Rules and Screening Tools for Protein Catalysts in Non-aqueous Environments"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Jarrett Pelton (University of North Carolina, United States)
"Cheminformatics-Guided Cell Free Biosynthetic Exploration of Peptide Natural Products"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
Euan Richards (ETH Zurich, Switzerland)
"Enabling an On-Demand Drug Library with High Throughput Synthesis and Cheminformatics."
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
