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High Throughput Chemistry and Chemical Biology (GRS)

Gordon Research Seminar

Developing Novel Technologies to Redefine Approaches in Drug Discovery

July 29 - 30, 2023
Chairs and
Colby-Sawyer College
541 Main Street
New London, New Hampshire, United States
 Venue and Travel Information

Conference Description

The High Throughput Chemistry and Chemical Biology GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

We will discuss recent advances in synthetic, medicinal, analytical and computational chemistry that enable the detection and modulation of undruggable targets. Other areas of interest in drug discovery will include high throughput experimentation, analytical development, novel chemistries and assay development along with informatics and AI-based analysis techniques. Our keynote speaker will be Professor Petra Dittrich from ETH Zurich. A diverse panel session including topics such as careers in academia, industry, and startup culture will take place at the 2023 GRS.

Related Meeting

This GRS will be held in conjunction with the "High Throughput Chemistry and Chemical Biology" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Technology and Platform Development
Discussion Leader:
3:45 pm - 4:20 pm
"High-Density Droplet Arrays for High Throughput Analysis"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advances in Chemistry and High-Throughput Synthesis + Career Discussion Panel
Discussion Leader:
7:30 pm - 7:45 pm
"Synthesis of Aliphatic Amines Using Borrowing Hydrogen and its Application to Large-Scale Drug Synthesis"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"High Throughput Chemistry for Direct to Biology screening against Bacterial E3 Ligases"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Miniaturized, Predictable, On-Demand Synthesis of Vast Libraries of Drug-Like Molecules"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 9:30 pm
Panel Discussion
Career Panel Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Hot Targets and Novel Discovery Approaches
Discussion Leader:
9:00 am - 9:15 am
"Activity-Based DEL Screening: Expanding the Druggable Proteome Through Selective Modulation of Translation"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"FICD Inhibitors: Discovery, Development and Validation"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Chemical Biology Approaches to Explore the Ligandability of TRIM E3 Ligases"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"A General Fluorescence-Based Assay Measuring Compound Accumulation in Cells"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
"Activity-Based Aptamer Screening"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
"Integrated High Throughput Synthesis and Screening Enable Discovery of Dynamic Protein Modulators"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Omics's and AI - Cheminformatics, Machine Learning, and High-throughput Analysis
Discussion Leader:
1:30 pm - 1:45 pm
"Developing Design Rules and Screening Tools for Protein Catalysts in Non-aqueous Environments"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
"Cheminformatics-Guided Cell Free Biosynthetic Exploration of Peptide Natural Products"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
"Enabling an On-Demand Drug Library with High Throughput Synthesis and Cheminformatics."
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes

Contributors

Gordon Research Conferences
Arrakis Therapeutics
IQ Proteomics

Conference Links

Conference History High Throughput Chemistry and Chemical Biology
Additional Fee Info

High Throughput Chemistry and Chemical Biology
July 27 - August 1, 2025


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