Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Discoveries of Epigenetic Modifications
Discussion Leader: Cheryl Arrowsmith (SGC, U of Toronto, Princess Margaret Cancer Centre, Canada)
7:40 pm - 8:25 pm
Peter Jones (Van Andel Institute, United States)
"Establishing and Maintaining DNA Methylation in Chromatin"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
Dinshaw Patel (Memorial Sloan-Kettering Cancer Center, United States)
"DNMT5-Mediated ATP-Dependent DNA Methylation"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Histone Lysine Methylation: Biology and Molecular Mechanisms
Discussion Leader: Xiaobing Shi (Van Andel Institute, United States)
9:00 am - 9:25 am
Kai Ge (NIH, United States)
"Enhancer Regulation by H3K4me1 Methyltransferases"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
Robert McGinty (UNC Chapel Hill, United States)
"Structural Basis of KDM2-Mediated H3K36 Demethylation"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
Yang Shi (Ludwig Institute for Cancer Research, Oxford University, United Kingdom)
"Chromatin Regulation in Immuno-Oncology"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Or Gozani (Stanford University, United States)
"Role of H3K36 Methylation in the Regulation of Chromatin and Cancer Biology"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Paul Wade (NIEHS, United States)
"Reprograming of Circadian Rhythms by Dietary Methionine Restriction"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Laura Banaszynski (University of Texas Southwestern Medical Center, United States)
"Retroelement Sequestration of Transcription Factors Fine-Tunes Developmental Gene Expression"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Yael David (Memorial Sloan Kettering Cancer Center, United States)
"Thinking Outside the Chromosome: Interrogating Epigenetic Mechanisms in Noncanonicalchromatin Species"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Song Tan (Pennsylvania State University, United States)
"General Principles for how Chromatin Enzymes and Factors Interact with the Nucleosome"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Robert Schneider (Institute for Functional Epigenetics, Germany) and Shannon Lauberth (Northwestern University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Biological Role of Histone Lysine Acylation
Discussion Leader: Mark Bedford (MD Anderson, United States)
7:30 pm - 7:55 pm
Xiaobing Shi (Van Andel Institute, United States)
"Histone Acetylation: Reading, Writing, and Beyond"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Jacques Cote (Laval University Cancer Research Center, Canada)
"Reading and Writing Histone Marks by MYST-Family Acetyltransferase Complexes in Genome Regulation and Disease"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Hong Wen (Van Andel Institute, United States)
"Targeting the Histone Acetylation Reader ENL in Cancer"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
James Galligan (University of Arizona, United States)
"Regulation of Inflammatory Signaling through Non-Enzymatic PTMs"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Chao Lu (Columbia University, United States)
"H3K27me3 Spreading Organizes Canonical PRC1 Chromatin Architecture to Regulate"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Histone lysine Acylation: Molecular Mechanisms
Discussion Leader: Hong Wen (Van Andel Institute, United States)
9:00 am - 9:25 am
Ming-Ming Zhou (Icahn School of Medicine at Mount Sinai, United States)
"New Mechanism of Epigenetic Control and Drug Discovery"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
John Denu (University of Wisconsin, United States)
"How Metabolism Informs the Epigenome"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
Philip Cole (Brigham and Women's Hospital/Harvard Medical School, United States)
"Chemical Approaches to Sorting Out Histone Modifications"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Haitao Li (Tsinghua University, China)
"Reading a Full Methylation State of H3K36me3 for Nucleosomal Deacetylation"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
Wenshe Liu (Texas A&M University, United States)
"Using a Phage Display System to Target Histone Epigenetic Enzymes and Readers for Drug Discovery"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
Christopher Schofield (Oxford University, United Kingdom)
"Oxygenase Catalysed Modifications of Histones and Nucleic Acids"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Crosstalk of Histone PTMs
Discussion Leader: Ming-Ming Zhou (Icahn School of Medicine at Mount Sinai, United States)
7:30 pm - 7:55 pm
Alessio Ciulli (University of Dundee, United Kingdom)
"Epigenetic Reader Domains as Binding Footholds to Selective PROTAC Degraders"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Erin Green (University of Maryland Baltimore County, United States)
"Chromatin Regulation and Signaling in Response to Stress"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Mark Bedford (MD Anderson, United States)
"Characterizing Methylarginine Effector Proteins"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Kanishk Jain (UNC Chapel Hill, United States)
"Understanding the Role of PHRF1 in Transcriptional Regulation and DNA Damage Repair"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Xiang David Li (The University of Hong Kong, Hong Kong SAR China)
"Chemical Approaches to Identify Histone Modification ‘readers’ in a Nucleosomal Context"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Chromatin Biology and DNA and RNA Modifications
Discussion Leader: Brian Strahl (UNC, United States)
9:00 am - 9:25 am
Steve Jacobsen (University of California, Los Angeles, United States)
"Mechanisms of Silencing by DNA Methylation"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
Joshua Black (UC Denver Anschutz Medical Center, United States)
"Epigenetic Regulation of DNA Re-Replication and Extrachromosomal DNA"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
Shannon Lauberth (Northwestern University, United States)
"The Role of Noncoding RNAs in Regulating the Epigenome: Shedding Light on the Transcriptomic Dark Matter"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Scott Rothbart (Van Andel Institute, United States)
"Mechanisms and Therapeutic Targeting of DNA Methylation Signaling"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
Daniel Panne (University of Leicester, United Kingdom)
"Control of Long-Range Chromatin Interactions by p300 and Cohesin"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Kristin Chesnutt (The Ohio State University, United States)
"ATAC and SAGA Histone Acetyltransferase Modules Facilitate Transcription Factor Binding to Nucleosomes in an Acetylation Independent Manner"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Natalia Tretyakova (University of Minnesota Masonic Cancer Center and Department of Medicinal Chemistry, United States)
"N6-Methyl-dA: a Novel DNA Epigenetic Mark in the Brain?"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Nucleosome Modifications: Molecular Mechanisms
Discussion Leader: Steve Jacobsen (University of California, Los Angeles, United States)
7:30 pm - 7:55 pm
Xiaodong Cheng (University of Texas MD Anderson Cancer Center, United States)
"Mediating and Maintaining DNA Methylation while Minimizing C-to-T Mutation"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Brian Strahl (UNC, United States)
"Chromatin Mechanisms and Novel Functions of Histone Code Writers"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Beat Fierz (École Polytechnique Fédérale de Lausanne, Switzerland)
"Dynamic Mechanisms of Reshaping the Chromatin Landscape"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Michael Keogh (EpiCypher Inc, United States)
"Nucleosome Conformation Dictates the Histone Code"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Dan Levy (Ben Gurion University of the Negev, Israel)
"Lysine Methylation Signaling at Chromatin"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Histone, DNA and RNA Modifications and Human Disease
Discussion Leader: Danica Fujimori (University of California, San Francisco, United States)
9:00 am - 9:25 am
Greg Wang (Duke University, Department of Pharmacology & Cancer Biology and Duke Cancer Institute, United States)
"Investigation of Histone Methylation Signaling for the Treatment of Cancers"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
Ian Maze (Howard Hughes Medical Institute at the Icahn School of Medicine at Mount Sinai, United States)
"Histone Monoaminylation: Novel Mechanisms of Neural Development, Plasticity and Disease"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Ho Man Chan (Astrazeneca, United States)
"Discovery of MTA-Cooperative PRMT5 Inhibitor for MTAP-Deleted Cancers"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Saulius Klimasauskas (Vilnius University, Lithuania)
"Chemical Tracking of Individual DNMT Writers during Cell State Transitions"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Johnathan Whetstine (Fox Chase Cancer Center, United States)
"Epigenetics: A Gatekeeper to DNA Amplification and Rearrangements"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
Akihiko Yokoyama (National Cancer Center Japan, Japan)
"Epigenetic Factors Responsible for the Aberrant Self-Renewal of Leukemia Cells"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Alejandro Vaquero (Josep Carreras Leukaemia Research Institute (IJC), Spain)
"SIRT7 at the Crossroad between Metabolic Homeostasis and Epigenetics in Aging"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Alexey Soshnev (University of Texas at San Antonio, United States)
"Linker Histone Mutant Interferes with Transcription Factor Function in Chromatin"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Epigenetic Therapeutics
Discussion Leader: Alessio Ciulli (University of Dundee, United Kingdom)
7:30 pm - 7:55 pm
Danica Fujimori (University of California, San Francisco, United States)
"Cyclic Peptide Probes for Chromatin Reader Domains"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Lindsey James (University of North Carolina, United States)
"Altering the H3 Methylation Landscape through Degradation of Methyl-Lysine Reader Proteins"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Jonathan Thomas (NYU Langone, United States)
"Structural Basis of Histone H2A Lysine 119 Deubiquitination by Polycomb Repressive Deubiquitinase BAP1/ASXL1"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
zhucheng chen (Tsinghua University, China)
"Mechanism of NuA4 in Nucleosomal H4 Acetylation"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Alina Rose (Helmholtz-Institut für Metabolismus-, Adipositas- und Gefäßforschung (HI-MAG), Germany)
"ACLY-Inhibition via Bempedoic Acid Reprograms the Hepatic Epigenetic, Transcriptional and Metabolic States"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Jikui Song (University of California, Riverside, United States)
"Suppress the Dominant-Negative Effect of DNMT3A Mutants in Leukemogenesis"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
