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Histone and DNA Modifications

Gordon Research Conference

Chromatin Modifications in Health and Disease

June 11 - 16, 2023

Chairs

and

Vice Chairs

and

Bryant University

1150 Douglas Pike

Smithfield, Rhode Island, United States

Venue and Travel Information

Conference Description

The Histone and DNA Modifications GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Histone and DNA modifications and their roles in epigenetic regulation have generated significant interest in the scientific community and continue dominating the research headlines. Methylation, acylation, phosphorylation and other modifications of histone proteins and DNA methylation play central roles in the transmission of epigenetic information. They dictate chromatin structure and function and are relevant to physiology and pathology. Recent seminal discoveries have greatly expanded our understanding of the importance of histone and DNA modifications; however, many essential questions remain unanswered. At our 2023 GRC on Histone and DNA Modifications we will discuss key concepts and mechanisms. This meeting will bring together scientists from multiple disciplines, including biology and chemistry, to exchange challenging viewpoints, expand expertise and collaborations, and stimulate novel ideas and discoveries.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Discoveries of Epigenetic Modifications Discussion Leader:
7:40 pm - 8:25 pm	"Establishing and Maintaining DNA Methylation in Chromatin"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 9:20 pm	"DNMT5-Mediated ATP-Dependent DNA Methylation"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Histone Lysine Methylation: Biology and Molecular Mechanisms Discussion Leader:
9:00 am - 9:25 am	"Enhancer Regulation by H3K4me1 Methyltransferases"
9:25 am - 9:30 am	Discussion
9:30 am - 9:55 am	"Structural Basis of KDM2-Mediated H3K36 Demethylation"
9:55 am - 10:00 am	Discussion
10:00 am - 10:25 am	"Chromatin Regulation in Immuno-Oncology"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:25 am	"Role of H3K36 Methylation in the Regulation of Chromatin and Cancer Biology"
11:25 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Reprograming of Circadian Rhythms by Dietary Methionine Restriction"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Retroelement Sequestration of Transcription Factors Fine-Tunes Developmental Gene Expression"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Thinking Outside the Chromosome: Interrogating Epigenetic Mechanisms in Noncanonicalchromatin Species"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"General Principles for how Chromatin Enzymes and Factors Interact with the Nucleosome"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: and
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Biological Role of Histone Lysine Acylation Discussion Leader:
7:30 pm - 7:55 pm	"Histone Acetylation: Reading, Writing, and Beyond"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:25 pm	"Reading and Writing Histone Marks by MYST-Family Acetyltransferase Complexes in Genome Regulation and Disease"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:55 pm	"Targeting the Histone Acetylation Reader ENL in Cancer"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Regulation of Inflammatory Signaling through Non-Enzymatic PTMs"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"H3K27me3 Spreading Organizes Canonical PRC1 Chromatin Architecture to Regulate"
9:25 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Histone lysine Acylation: Molecular Mechanisms Discussion Leader:
9:00 am - 9:25 am	"New Mechanism of Epigenetic Control and Drug Discovery"
9:25 am - 9:30 am	Discussion
9:30 am - 9:55 am	"How Metabolism Informs the Epigenome"
9:55 am - 10:00 am	Discussion
10:00 am - 10:25 am	"Chemical Approaches to Sorting Out Histone Modifications"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:25 am	"Reading a Full Methylation State of H3K36me3 for Nucleosomal Deacetylation"
11:25 am - 11:30 am	Discussion
11:30 am - 11:55 am	"Using a Phage Display System to Target Histone Epigenetic Enzymes and Readers for Drug Discovery"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:25 pm	"Oxygenase Catalysed Modifications of Histones and Nucleic Acids"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Crosstalk of Histone PTMs Discussion Leader:
7:30 pm - 7:55 pm	"Epigenetic Reader Domains as Binding Footholds to Selective PROTAC Degraders"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:25 pm	"Chromatin Regulation and Signaling in Response to Stress"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:55 pm	"Characterizing Methylarginine Effector Proteins"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Understanding the Role of PHRF1 in Transcriptional Regulation and DNA Damage Repair"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Chemical Approaches to Identify Histone Modification ‘readers’ in a Nucleosomal Context"
9:25 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Chromatin Biology and DNA and RNA Modifications Discussion Leader:
9:00 am - 9:25 am	"Mechanisms of Silencing by DNA Methylation"
9:25 am - 9:30 am	Discussion
9:30 am - 9:55 am	"Epigenetic Regulation of DNA Re-Replication and Extrachromosomal DNA"
9:55 am - 10:00 am	Discussion
10:00 am - 10:25 am	"The Role of Noncoding RNAs in Regulating the Epigenome: Shedding Light on the Transcriptomic Dark Matter"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:25 am	"Mechanisms and Therapeutic Targeting of DNA Methylation Signaling"
11:25 am - 11:30 am	Discussion
11:30 am - 11:55 am	"Control of Long-Range Chromatin Interactions by p300 and Cohesin"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"ATAC and SAGA Histone Acetyltransferase Modules Facilitate Transcription Factor Binding to Nucleosomes in an Acetylation Independent Manner"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"N6-Methyl-dA: a Novel DNA Epigenetic Mark in the Brain?"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Nucleosome Modifications: Molecular Mechanisms Discussion Leader:
7:30 pm - 7:55 pm	"Mediating and Maintaining DNA Methylation while Minimizing C-to-T Mutation"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:25 pm	"Chromatin Mechanisms and Novel Functions of Histone Code Writers"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:55 pm	"Dynamic Mechanisms of Reshaping the Chromatin Landscape"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Nucleosome Conformation Dictates the Histone Code"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Lysine Methylation Signaling at Chromatin"
9:25 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Histone, DNA and RNA Modifications and Human Disease Discussion Leader:
9:00 am - 9:25 am	"Investigation of Histone Methylation Signaling for the Treatment of Cancers"
9:25 am - 9:30 am	Discussion
9:30 am - 9:55 am	"Histone Monoaminylation: Novel Mechanisms of Neural Development, Plasticity and Disease"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Discovery of MTA-Cooperative PRMT5 Inhibitor for MTAP-Deleted Cancers"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Chemical Tracking of Individual DNMT Writers during Cell State Transitions"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:25 am	"Epigenetics: A Gatekeeper to DNA Amplification and Rearrangements"
11:25 am - 11:30 am	Discussion
11:30 am - 11:55 am	"Epigenetic Factors Responsible for the Aberrant Self-Renewal of Leukemia Cells"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"SIRT7 at the Crossroad between Metabolic Homeostasis and Epigenetics in Aging"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Linker Histone Mutant Interferes with Transcription Factor Function in Chromatin"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Epigenetic Therapeutics Discussion Leader:
7:30 pm - 7:55 pm	"Cyclic Peptide Probes for Chromatin Reader Domains"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:25 pm	"Altering the H3 Methylation Landscape through Degradation of Methyl-Lysine Reader Proteins"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"Structural Basis of Histone H2A Lysine 119 Deubiquitination by Polycomb Repressive Deubiquitinase BAP1/ASXL1"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Mechanism of NuA4 in Nucleosomal H4 Acetylation"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"ACLY-Inhibition via Bempedoic Acid Reprograms the Hepatic Epigenetic, Transcriptional and Metabolic States"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Suppress the Dominant-Negative Effect of DNMT3A Mutants in Leukemogenesis"
9:25 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

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