SUNDAY, AUGUST 9
- 2:00-6:00pm - Conference Office Opens - Level 1, Simon Center, Registration
- 6:00-7:00pm - Dinner, Gilmore Hall
- 7:00-11:00pm - Office Open - Level 1, Simon Center
All Scientific Sessions and Poster Sessions are to be held on Level 2 of the Simon Center
- 7:30-7:45pm - Welcome, Betty Eipper
SESSION 1
7:45-10:00pm |
Genetic models for understanding processing enzyme function in vivo |
Discussion Leader - John Hutton
- 7:45-8:15 - Don Steiner - University of Chicago - "Mutations Reveal Major Role of PC2 in Neuroendocrine Precursor Processing"
- 8:15-8:45 - Paul Taghert - Washington University School of Medicine - "The Molecular Genetics of Neuropeptide Biosynthesis in Drosophila"
- 8:45-9:15 - Lloyd Fricker - Albert Einstein College of Medicine - "Peptide Processing Carboxypeptidases: Of Mice and Molecules"
- 9:15-9:45 - Majambu Mbikay - Clinical Research Institute of Montreal - "Genetic Deficiencies of Proprotein Convertases PC1 and PC4 in Mouse"
- 9:45-10:00 - Jacques Peschon - Immunex Corp. - "Diverse protein ectodomain
shedding defects and perinatal lethality in mice lacking catalytically active TACE"
MONDAY, AUGUST 10
- 6:30-8:30am - Breakfast, Gilmore Hall
- 8:00am-12:30pm - Office Open - Level 1, Simon Center
- 8:00-9:00am - Set-up posters for Poster Session I - Level 2, Simon Center
SESSION 2
9:00am-12:30pm |
The TGN: Models for membrane protein localization and sorting. |
Discussion Leader - Sharon Tooze
- 9:00-9:30 - Kathryn Howell -University of Colorado Health Sciences Center - "Structural-Functional Relationships of the TGN"
- 9:30-10:00 - Dave Castle - University of Virgina Health Sciences Center - "Proteins in Post-Golgi Membranes; the SCAMP Perspective"
- 10:00-10:30 - Juan Bonifacino - Cell Biology and Metabolism Branch, NIH/NICHD - "Impaired biogenesis of secretory lysosomes in patients with Hermansky-Pudlak Syndrome"
- 10:30-11:00 - Coffee Break
- 11:00-11:30 - Greg Payne - UCLA School of Medicine - "Golgi Membrane Protein Sorting in Yeast"
- 11:30-11:45 - Amy Chang - Albert Einstein College of Medicine - "A Targeting Defective Plasma Membrane ATPase Mutant Provides Evidence for a Golgi Quality Control System"
- 11:45-12:15 - Tom Stevens - University of Oregon - "Retention and Recycling of Yeast TGN Membrane Proteins"
- 12:15-12:30 - Christopher G. Burd (NIH short talk awardee) - "Specific binding of RING FYVE domains to PtdIns(3)P links regulation of membrane trafficking to PI(3) kinase signaling"
- 12:30-1:30 - Lunch, Gilmore Hall
- 1:30-11:00pm - Office Open - Level 1, Simon Center
- 4:00-6:00pm - Poster Session I - Level 2, Simon Center (posters will remain up until Tuesday night)
- 6:00-7:00pm - Dinner, Gilmore Hall
SESSION 3
7:30-10:15pm |
Biochemistry and structural analysis of processing enzymes. |
Discussion Leader - Bob Fuller
- 7:30-8:00 - Phil Bryan - CARB - University of Maryland - "The Role of the Pro-domain in Subtilisin Folding"
- 8:00-8:15 - An Zhou - University of Chicago - "The Regulatory Roles of the P Domain
of Subtilisin-like Prohormone Convertases"
- 8:15-8:45 - Iris Lindberg - Louisiana State University - "Activation and Regulation of Prohormone Convertase 2"
- 8:45-9:00 - Break
- 9:00-9:15 - Nathan Rockwell - University of Michigan - "Specificity and Mechanism in Processing Proteases"
- 9:15-9:45 - Nabil Seidah - Clinical Research Institute of Montreal - "Paralogs of the Subtilisin/Kexin Family of Serine Proteinases"
- 9:45-10:15 - Anton Roebroek - University of Leuven - "Defective Ventral Closure of Furin-Deficient Mouse Embryos"
TUESDAY, AUGUST 11
- 6:30-8:30am - Breakfast, Gilmore Hall
- 7:30am - First NSF Poster Award Committee Meeting
- 8:00am-12:30pm - Office Open - Level 1, Simon Center
- 8:30-8:45am - GROUP PHOTO - near Bell Tower behind Simon Center
SESSION 4
9:00am-12:30pm |
Sorting of lumenal proteins |
Discussion Leader - Sharon Milgram
- 9:00-9:30 - Peter Arvan - Albert Einstein College of Medicine - "Sorting of Exportable Proteins in Golgi/Post-Golgi Compartments of Regulated Secretory Cells"
- 9:30-10:00 - Y. Peng Loh -NICHD, National Institutes of Health - "Receptor-mediated Sorting of Prohormones to the Regulated Secretory Pathway"
- 10:00-10:30 - Wieland Huttner - University of Heidelberg - "Chromogranin Sorting and Biogenesis of Neuroendocrine Secretory Granules"
- 10:30-11:00 - Coffee
- 11:00-11:30 - Priscilla Dannies - "Specificity in sorting prolactin and growth hormone in the secretory pathway"
- 11:30-12:00 - Dan Cutler - MRC Laboratory of Molecular Cell Biology - "Targeting of P-selectin to granules, micro-vesicles and lysosomes"
- 12:00-12:15 - Regina Kuliawat - Albert Einstein College of Medicine - "Endoproteolytic Processing of Proinsulin Contributes to Insulin Targeting to Secretory Granules"
- 12:15-12:30 - Vivian Y.H. Hook (NIH short talk awardee) - "Molecular cloning reveals a novel protease-specific, isoform of inhibitor α1-antichymotrypsin localized to secretory vesicles: role in proenkephalin and phoromone processing"
- 12:30-1:30pm - Lunch, Gilmore Hall
- 1:30-11:00pm - Office Open - Level 1, Simon Center
- 6:00-7:00pm - Dinner, Gilmore Hall
SESSION 5
7:30-10:15pm |
Processing enzymes that function outside of the secretory pathway. |
Discussion Leader - Nabil Seidah
- 7:30-8:00 - Ardythe McCracken - University of Nevada, Reno - "Proteasome-dependent ER-Associated Protein Degradation"
- 8:00-8:30 - David Livingston - Vertex Pharmaceuticals, Inc. - "Processing of Cytokine Precursors by ICE (Caspase-1) and Other Caspases "
- 8:30-8:45 - Brett Lauring (NIH short talk awardee) - "A general mechanism for regulation of access to the translocon: competition for a membrane attachment site on ribosomes"
- 8:45-9:00 - Break
- 9:00-9:30 - Carl Blobel - "Metalloprotease-disintegrins: biosynthesis, role in cell-cell interaction, and catalytic activity"
- 9:30-10:00 - Roy Black - Immunex Corp. - "TACE: A Multi-domain, Transmembrane Proteolytic Processing Enzyme"
- 10:00-10:15 - John Tullai (NIH short talk awardee) - "Trafficking studies of the processing peptidase EC3.4.24.15"
- 10:15pm - Dismantling of Poster Session I - Level 2, Simon Center
WEDNESDAY, AUGUST 12
- 6:30-8:30am - Breakfast, Gilmore Hall
- 8:00am-12:30pm - Office Open - Level 1, Simon Center
- 8:00-9:00am - Set-up posters for Poster Session II - Level 2, Simon Center
SESSION 6
9:00am-12:30pm |
Sorting of essential membrane proteins. |
Discussion Leader - Peter Arvan
- 9:00-9:30 - Bob Fuller - University of Michigan - "Kex2p Localization via TGN-Endosome Cycling in Yeast"
- 9:30-10:00 - Sharon Milgram - University of North Carolina, Chapel Hill - "Protein-Protein Interactions within the Secretory Pathway and in Cytosol that Mediate the Targeting of PAM to Secretory Granules and to the TGN"
- 10:00-10:30 - Dick Mains - Johns Hopkins University School of Medicine - "Dbl Family Members and Protein Kinases Involved in Trafficking of Secretory Granule Proteins"
- 10:30-11:00 - Coffee
- 11:00-11:30 - Gary Thomas - Vollum Institute, University of Oregon - "Furin Sorting Proteins"
- 11:30-12:00 - Robert Edwards - University of California, San Francisco - "Membrane Trafficking of Vesicular Neurotransmitter Transporters"
- 12:00-12:15 - Stanny Berghs (NIH short talk awardee) - "Identification of GRASPIN, a novel interactor of the receptor protein tyrosine phosphatase-like protein ICA512"
- 12:15-12:30 - John Creemers (NIH short talk awardee) - "Trans-Golgi network localization of the proprotein convertase LPC and internalization from the cell surface mediated by a novel motif"
- 12:30-1:30pm - Lunch, Gilmore Hall
- 1:30-11:00pm - Office Open - Level 1, Simon Center
- 4:00-6:00pm - Poster Session II - Level 2, Simon Center (posters will remain up until Thursday night)
- 6:00-7:00pm - Dinner - Gilmore Hall
SESSION 7
7:30-10:15pm |
Developmental and physiological regulation of the synthesis and processing of hormonal and neural peptides. |
Discussion Leaders - Iris Lindberg / Michel Chretien
- 7:30-8:00 - Aaron Turkewitz - University of Chicago - "Roles of Ca2+-Binding and Proteolytic Processing in the Regulated Exocytic Pathway of Tetrahymena"
- 8:00-8:30 - John Hutton - University of Colorado Health Sciences Center - "Secretory Granule Protein Tyrosine Phosphatase Members. Role in Secretion and Disease"
- 8:30-9:00 - John Pintar - UMDNJ-Robert Wood Johnson Medical School - "Ontogeny of Processing Enzyme Expression during Mammalian Development"
- 9:00-9:15 - Break
- 9:15-9:45 - Robert Jackson - Addenbrooke's Hospital - "Human PC1, Obesity and Polyendocrinopathy"
- 9:45-10:00 - Michel Chretien - Clinical Research Institute of Montreal - "Clinical
Relevance of Convertases"
- 10:00-10:15 - Christoph Westphal (NIH short talk awardee) - "Transposon-based knock-out of neuroendocrine 7B2 reveals essential role in glucose and body fat regulation"
THURSDAY, AUGUST 13
- 6:30-8:30am - Breakfast, Gilmore Hall
- 7:30am - Second NSF Poster Award Committee Meeting
- 8:00am-12:30pm - Office Open - Level 1, Simon Center
SESSION 8
9:00am-12:30pm |
Formation and maturation of secretory vesicles. |
Discussion Leader - Tom Martin
- 9:00-9:30 - Dennis Shields - Albert Einstein College of Medicine - "Regulation of Nascent Secretory Vesicle Formation"
- 9:30-10:00 - Sharon Tooze - Imperial Cancer Research Fund, London - "Maturation of Secretory Granules: Homotypic Fusion"
- 10:00-10:30 - Mike Roth - University of Texas Southwestern Medical Center - "Phospholipase D as an Effector for ARF Function in Vesicular Transport"
- 10:30-11:00 - Coffee
- 11:00-11:30 - Hsiao Ping Moore - University of California, Berkeley - "Molecular Events Involved in ACTH-granule Biogenesis"
- 11:30-11:45 - Giulia Baldini - Columbia University - "Role of Rab3 Proteins in ACTH
Secretion"
- 11:45-12:15 - Hans Herman Gerdes - Heidelberg University - "Sorting and Vesicular Traffic of Human Chromogranin B Imaged with Green Fluorescent Protein"
- 12:15-12:30 - Jim Jamieson (NIH short talk awardee) - "The subapical actin cytoskeleton regulates exocytosis and membrane retrieval in pancreatic acinar cells"
- 12:30-1:30pm - Lunch, Gilmore Hall
- 1:30-11:00pm - Office Open - Level 1, Simon Center
- 5:00-6:00pm - Business Meeting - All Participants - Level 2, Simon Center
- Presentation of NSF Poster Awards
- Election of Chair and Vice-Chair
6:00-7:00pm - BANQUET, Gilmore Hall
SESSION 9
7:30-9:30pm |
Release of bioactive peptides: the process of exocytosis. |
Discussion Leader - Dick Mains
- 7:30-8:00 - Romano Regazzi - Institut de Biologie Cellulaire et Morphologie, Lausanne - "Small GTPases
and SNAREs in regulated secretion"
- 8:00-8:30 - Robert Chow - University of Edingurgh Medical School - "Regulation of Exocytosis in Adrenal Chromaffin Cells"
- 8:30-9:00 - Mary Bittner - University of Michigan Medical School - "α-Latrotoxin Mediates Effects on Secretion by Multiple Mechanisms"
- 9:00-9:30 - Tom Martin - University of Wisconsin - "Late Stages of Dense Core Vesicle Exocytosis"
- 9:30 - Dismantling of Poster Session II - Level 2, Simon Center
- 9:30-12:30 - Social Event - Pub and Coffee Break Area
FRIDAY, AUGUST 14
- 6:30-8:30am - Breakfast, Gilmore Hall
- 8:00-10:00am - Office Open - Level 1, Simon Center
- 8:30am - Chartered Bus Loads
|
