This conference will bring together leading scientists, working in academia, medicine and industry, on the hormonal control of development, reproduction and cancer. This unique mixture of researchers and topics will provide a synergistic cross-fertilization of ideas and knowledge. Major topics will include hormone action on gene expression, development and physiology, and how these pathways can be manipulated by mutations, endocrine disruptors, diet and lifestyle. A new sub-focus for this year will be the hormonal control of metabolism, and the reciprocal roles of newly discovered metabolic hormones on development, clocks, behavior and disease. A major effort will be made to stimulate interactions between the invited speakers and the many young scientists and trainees attending. This effort will begin with a two day Gordon Research Seminar, organized by and for trainees, that will precede the conference. We expect the eclectic mix of invited scientists, together with the unprecedented numbers of new and enthusiastic young trainees, will make for an unusually interactive, stimulating and productive conference.