Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Modeling of Hormone Action
Discussion Leaders: Daniel Gioeli (University of Virginia, USA) and Ruth Keri (Case Western Reserve University, USA)
7:40 pm - 8:05 pm
Elaine Alarid (University of Wisconsin-Madison, USA)
"The Evolution of Hormone-Dependent Cancer Research"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Wayne Tilley (University of Adelaide, Australia)
"From Dog Testicles to Super-Castration: A Historical Perspective of the Androgen Receptor"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Cathrin Brisken (École Polytechnique Fédérale de Lausanne, Switzerland)
"Hormone-Dependent Breast Carcinogenesis: How Models Matter"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Advances in Targeting Steroid Receptors
Discussion Leaders: Rachael Natrajan (The Institute of Cancer Research, London, United Kingdom) and Wilbert Zwart (Netherlands Cancer Institute, The Netherlands)
9:00 am - 9:20 am
Charlotte Bevan (Imperial College London, United Kingdom)
"Androgen Receptor and Non-Coding RNA: The Long and the Short of It"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Yan Dong (Tulane University School of Medicine, USA)
"Circular RNAs Add Diversity to Androgen Receptor Isoform Repertoire"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Jonna Frasor (University of Illinois at Chicago, USA)
"ER and NFkB Regulated Breast Cancer Phenotypes"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Luke Selth (University of Adelaide, Australia)
"New Mechanistic and Therapeutic Insights into Aberrant Androgen Receptor Signaling in Prostate Cancer"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Ganesh Raj (University of Texas Southwestern Medical Center, USA)
"Mutants, Variants and Their Drugs"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Nilgun Tasdemir (UPMC Hillman Cancer Center, University of Pittsburgh, USA) and Dorraya El-Ashry (Breast Cancer Research Foundation / Masonic Cancer Center, University of Minnesota, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Immuno-Oncology in Hormone-Dependent Cancers
Discussion Leader: Elgene Lim (Garvan Institute of Medical Research, Australia)
7:30 pm - 7:50 pm
Leisha Emens (UPMC Hillman Cancer Center, USA)
"Harnessing the Immune System for Breast Cancer Therapy"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Justin Balko (Vanderbilt University Medical Center, USA)
"Combination Therapies to Enhance Anti-Tumor Immunity in Luminal Breast Cancers"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Haydn Kissick (Emory University, USA)
"The Hostile Immune Microenvironment in Prostate Cancer"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Heide Ford (University of Colorado Anschutz Medical Campus, USA)
"EMT Regulators in Immune Evasion of Breast Cancer"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Genetic Drivers of Heterogeneity and Progression in Hormone-Dependent Cancers
Discussion Leaders: Daniel Frigo (University of Texas MD Anderson Cancer Center, USA) and Michael Gatza (Rutgers Cancer Institute of New Jersey, USA)
9:00 am - 9:20 am
Leonie Young (Royal College of Surgeons in Ireland, Ireland)
"Molecular Heterogeneity in ER Positive Metastatic Breast Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Jennifer Richer (University of Colorado Anschutz Medical Campus, USA)
"How Hormone Deprivation Influences Breast Cancer Immune Suppression"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Luca Magnani (Imperial College London, United Kingdom)
"Cracking the Code: Diving into the Non-Coding Genome of Hormone Dependent Cancers to Unravel Its Drivers"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Geoffrey Greene (University of Chicago, USA)
"New Ways to Exploit Steroid Receptors for Breast Cancer Prevention and Treatment"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Scott Dehm (University of Minnesota, USA)
"Clonal Evolution of the Androgen Receptor During Prostate Cancer Progression"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Functional and Clinical Insight into Gynecological Cancers and TNBC
Discussion Leaders: Carol Lange (University of Minnesota, USA) and Scott Cramer (University of Colorado Denver, USA)
7:30 pm - 7:50 pm
Analisa DiFeo (University of Michigan, USA)
"Dissecting the Complexity of miRNAs in Ovarian Cancer Pathogenesis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Rugang Zhang (The Wistar Institute, USA)
"Epigenetic Approaches to CARM1-Expressing Ovarian Cancer"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Helen Piwnica-Worms (The University of Texas MD Anderson Cancer Center, USA)
"Identifying and Targeting Vulnerabilities in Chemotherapy-Resistant Triple Negative Breast Cancer"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Julie Kim (Northwestern University, USA)
"Understanding Endometrial Tumorigenesis: A New Frontier"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Darcie Seachrist (Case Western Reserve University, USA)
"BCL11A Induces Triple-Negative Breast Cancer Invasion and Metastasis by Suppressing MBNL1-Associated Alternative Splicing"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Targets and Clinical Trials
Discussion Leaders: Christopher Sweeney (Dana-Farber Cancer Institute, USA) and Massimo Loda (NewYork-Presbyterian/Weill Cornell Medical Center, USA)
9:00 am - 9:20 am
Sarat Chandarlapaty (Memorial Sloan Kettering Cancer Center, USA)
"Resistance to Combination Endocrine Therapy: Mechanisms and Therapeutic Implications"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Douglas Yee (Masonic Cancer Center, University of Minnesota, USA)
"Neoadjuvant Breast Cancer Therapy as a Platform to Evaluate Novel Agents"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Matthew Ringel (Ohio State University, USA)
"Genomics of Metastatic and Resistant Thyroid Cancer: Defining New Therapeutic Targets"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Michael Schweizer (University of Washington, USA)
"Targeting Prostate Cancer Drug Resistance"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Suzanne Conzen (University of Texas Southwestern Medical Center, USA)
"Epigenetic Mechanisms of Glucocorticoid Receptor Signaling in Cancer"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Michael Cook (National Cancer Institute, NIH, USA)
"Racial Differences in Prostate Cancer"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Early-Career Investigator Presentations
Discussion Leaders: Matthew Sikora (University of Colorado Anschutz Medical Campus, USA) and Rebecca Riggins (Georgetown University, USA)
7:30 pm - 7:45 pm
Sankari Nagarajan (Cancer Research UK Cambridge Institute, United Kingdom)
"Genome-Wide CRISPR Screening Identifies SWI/SNF Chromatin Remodeling Complex in Endocrine Drug Resistance"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Damir Varešlija (Royal College of Surgeons in Ireland, Ireland)
"Novel Molecular Determinants of Metastatic Breast Cancer"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Erin Giles (Texas A&M University, USA)
"Impact of Obesity and Weight Gain on Postmenopausal Breast Cancers: Insight from Preclinical Models"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Stacey Joosten (Netherlands Cancer Institute, The Netherlands)
"Hormone Receptor Cross-Talk in Breast Cancer"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Eric Bolf (University of Vermont, USA)
"Thyroid Hormone Mediated Tumor Suppression in Anaplastic Thyroid Cancer"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Emmanuel Rosas (University of Colorado Anschutz Medical Campus, USA)
"TGFβ Crosstalk with Androgen Receptors in Triple-Negative Breast Cancer"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Rehana Qureshi (University of Miami, USA)
"Loss of Ovarian Estradiol and Increased Estrone in Obesity Promote Postmenopausal Mammary Inflammation and ER+ Breast Cancer Progression"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Computational Approaches and Big Data
Discussion Leaders: Adrian Lee (UPMC Hillman Cancer Center, USA) and Jay Gertz (University of Utah, USA)
9:00 am - 9:20 am
Francesca Demichelis (University of Trento, Italy)
"Hormone-Dependent Cancers Evolution from Unbiased Allele Specific Analyses"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Ethan Sokol (Foundation Medicine, USA)
"Uncovering Vulnerabilities in Advanced Lobular Carcinomas Through Genomic Profiling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Nikhil Wagle (Dana-Farber Cancer Institute, USA)
"Drivers of Breast Cancer Metastases"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Alex Swarbrick (Garvan Institute of Medical Research, Australia)
"Exploring the Breast and Prostate Microenvironment Using Multi-Dimensional Single Cell Genomics"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Jorge Reis-Filho (Memorial Sloan Kettering Cancer Center, USA)
"Unique Breast Cancer Subtypes"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Priyamvada Rai (Miller School of Medicine, University of Miami, USA)
"Novel Redox-Regulated Mechanisms Underlying Castration-Resistant Prostate Cancer Progression"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Martin Sjöström (University of California, San Francisco, USA)
"Comprehensive Transcriptomic Profiling Identifies Breast Cancer Patients Who May Be Spared Adjuvant Systemic Therapy"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Keynote Session: New Perspectives in Therapeutic Targeting of Hormone-Dependent Cancers
Discussion Leaders: Karen Knudsen (Sidney Kimmel Cancer Center, Jefferson Health, USA) and Kerry Burnstein (Miller School of Medicine, University of Miami, USA)
5:30 pm - 5:55 pm
Ciara Metcalfe (Genentech, USA)
"Next Generation ER Therapeutics for Breast Cancer: Same Strategy, Different Beasts"
5:55 pm - 6:05 pm
Discussion
6:05 pm - 6:30 pm
Carlo Palmieri (University of Liverpool, United Kingdom)
"Endocrine Therapy: Revisiting the Past to Discover the Future"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
Christopher Sweeney (Dana-Farber Cancer Institute, USA)
"Fickle, Thy Name Is Androgen Receptor"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
