Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Advances in Targeting Steroid Receptors
7:40 pm - 8:10 pm
"Gain of Function Activities of Mutant ER in Breast Cancer – Opportunities for Targeting?"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 8:55 pm
"The Challenge of Targeting Mutant ER in Therapy Resistant Breast Cancer"
8:55 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
DNA Repair Deficiency in Hormone-Dependent Cancers
9:00 am - 9:20 am
"RNA Polymerase I Inhibitors in Prostate Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"The AR, DNA Damage and DNA Repair: A 3-Way Intersection for Prostate Cancer Therapy"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Synergy Between the Tumour Microenvironment and Genomics in Determining Prostate Cancer Aggression"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cancer Genomics and Genetics
7:30 pm - 7:50 pm
"Genomic Evolution During Breast Cancer Metastasis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"The Epitranscriptomic Landscape in Localized Prostate Cancer"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Genomic and Epigenomic Mechanisms of Targeted Therapy Resistance"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Come on Feel the Noise: The Role of Regulatory Elements in Single Cell Hormone Responses"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Drivers of Heterogeneity and Progression in Hormone-Dependent Cancers
9:00 am - 9:20 am
"Epigenetic Factors Underlying the Action of Steroid Hormones"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Epigenomic Modifications in Breast Cancer Brain Metastases"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Context Dependency of Hormone Receptor Action in Cancer"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"New Insight into Context-Specific Androgen Receptor Signaling in Breast Cancer"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Late-Breaking Topic
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tumor Immunology and Dormancy
7:30 pm - 7:50 pm
"Tumor-localized IL-12 Therapy Combats an Increasingly Immunosuppressive Tumor Microenvironment Driven by Effective STEAP1 CAR T Cell Therapy in Prostate Cancer"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Interplay Between Metabolism and Senescence in Ovarian Cancer"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Tumor Heterogeneity and Resistance to Hormone Therapy in Breast Cancer"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
The Evolving Role of Tumor Microenvironment in Cancer Progression
9:00 am - 9:20 am
"Cell Intrinsic and Extrinsic Roles for the RUNX/CBFb Complex in Breast Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Tumor Initiation Through Aberrant Differentiation: Lessons from Single Cell Genomics"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Mechanisms of Treatment Resistance in Hormone-Dependent Cancers"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Epigenetic Reprogramming of the Prostate Cancer Tumor Microenvironment to Increase Response to Immunotherapy"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Cellular Interactions in the Prostate Bone Microenvironment that Drive Treatment Resistance"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Targets and Clinical Trials in Hormone-Related Cancers
7:30 pm - 7:50 pm
"Glucocorticoid Receptors Act as Cellular Stress Sensors in Triple Negative Breast Cancer"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Emerging Biomarkers to Detect Phenotypic Subtypes of Advanced Prostate Cancer"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Clinical Trials in Hormone-Related Cancers"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"ASCL1: A Bridge Between Cell Surface Receptor and The Epigenome to Support Lineage Plasticity in Prostate Cancer"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Defining and Addressing the Next Big Question in Hormone-Related Cancers
9:00 am - 9:40 am
"New Ways of Authoring in the Digital Age"
9:40 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Introduction by Discussion Leader
10:50 am - 11:00 am
General Discussion
11:00 am - 11:20 am
"Alternative Mechanisms for the Clinical Benefit of Combining Androgen Deprivation Therapy with Radiation Therapy for Prostate Cancer"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"What's Next for Estrogen Receptor?"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Translating Novel Targets in Hormone-Related Cancers into the Industry Setting
7:30 pm - 7:50 pm
"Translating the Cancer Genome to the Clinic"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Putting the Squeeze on Breast & Prostate Cancers with Next-Generation Hormone-Receptor Therapeutics."
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"The Fate of Prostate Cancer Cells Treated With PRC2 Inhibitors"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Introduction by Discussion Leader
9:10 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure