Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Advances in Targeting Steroid Receptors
Discussion Leader: Wayne Tilley (University of Adelaide, Australia)
7:40 pm - 8:10 pm
Steffi Oesterreich (UPMC Hillman Cancer Center , United States)
"Gain of Function Activities of Mutant ER in Breast Cancer – Opportunities for Targeting?"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 8:55 pm
Geoffrey Greene (University of Chicago, United States)
"The Challenge of Targeting Mutant ER in Therapy Resistant Breast Cancer"
8:55 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
DNA Repair Deficiency in Hormone-Dependent Cancers
Discussion Leaders: Francesca Demichelis (University of Trento, Italy) and Steve Balk (Beth Israel Deaconess Medical Center, United States)
9:00 am - 9:20 am
Luc Furic (Peter MacCallum Cancer Centre, Australia)
"RNA Polymerase I Inhibitors in Prostate Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Peter Nelson (Fred Hutchinson Cancer Center, United States)
"The AR, DNA Damage and DNA Repair: A 3-Way Intersection for Prostate Cancer Therapy"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Judy Garber (Dana-Farber Cancer Institute, United States)
"Cancer Genetics"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Robert Bristow (University of Manchester, United Kingdom)
"Synergy Between the Tumour Microenvironment and Genomics in Determining Prostate Cancer Aggression"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Katherine Aird (University of Pittsburgh, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cancer Genomics and Genetics
Discussion Leaders: Alex Swarbrick (Garvan Institute of Medical Research, Australia) and Scott Dehm (University of Minnesota, United States)
7:30 pm - 7:50 pm
Adrian Lee (University of Pittsburgh, United States)
"Genomic Evolution During Breast Cancer Metastasis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Housheng He (Princess Margaret Cancer Center, University of Toronto, Canada)
"The Epitranscriptomic Landscape in Localized Prostate Cancer"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
David Quigley (University of California San Francisco, United States)
"Genomic and Epigenomic Mechanisms of Targeted Therapy Resistance"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Jay Gertz (University of Utah, United States)
"Come on Feel the Noise: The Role of Regulatory Elements in Single Cell Hormone Responses"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Drivers of Heterogeneity and Progression in Hormone-Dependent Cancers
Discussion Leaders: Charlotte Bevan (Imperial College London, United Kingdom) and Suzanne Conzen (UT Southwestern, United States)
9:00 am - 9:20 am
Myles Brown (Dana-Farber Cancer Institute, United States)
"Epigenetic Factors Underlying the Action of Steroid Hormones"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Damir Varešlija (RCSI University of Medicine and Health Sciences, Ireland)
"Epigenomic Modifications in Breast Cancer Brain Metastases"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Wilbert Zwart (Netherlands Cancer Institute, The Netherlands)
"Context Dependency of Hormone Receptor Action in Cancer"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Theresa Hickey (University of Adelaide, Australia)
"New Insight into Context-Specific Androgen Receptor Signaling in Breast Cancer"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Late-Breaking Topic
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tumor Immunology and Dormancy
Discussion Leaders: Cathrin Brisken (École Polytechnique Fédérale de Lausanne, Switzerland) and Luke Selth (Flinders University, Australia)
7:30 pm - 7:50 pm
John Lee (Fred Hutchinson Cancer Center, United States)
"Tumor-localized IL-12 Therapy Combats an Increasingly Immunosuppressive Tumor Microenvironment Driven by Effective STEAP1 CAR T Cell Therapy in Prostate Cancer"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Katherine Aird (University of Pittsburgh, United States)
"Interplay Between Metabolism and Senescence in Ovarian Cancer"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Maria Vivanco (CIC bioGUNE, Spain)
"Tumor Heterogeneity and Resistance to Hormone Therapy in Breast Cancer"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
The Evolving Role of Tumor Microenvironment in Cancer Progression
Discussion Leader: Daniel Frigo (University of Texas MD Anderson Cancer Center, United States)
9:00 am - 9:20 am
Karen Blyth (Cancer Research UK Beatson Institute, United Kingdom)
"Cell Intrinsic and Extrinsic Roles for the RUNX/CBFb Complex in Breast Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Walid Khaled (University of Cambridge, United Kingdom)
"Tumor Initiation Through Aberrant Differentiation: Lessons from Single Cell Genomics"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Jason Carroll (University of Cambridge, United Kingdom)
"Mechanisms of Treatment Resistance in Hormone-Dependent Cancers"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Leigh Ellis (Cedars-Sinai Medical Center, United States)
"Epigenetic Reprogramming of the Prostate Cancer Tumor Microenvironment to Increase Response to Immunotherapy"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Joshua Lang (University of Wisconsin-Madison, United States)
"Cellular Interactions in the Prostate Bone Microenvironment that Drive Treatment Resistance"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Targets and Clinical Trials in Hormone-Related Cancers
Discussion Leaders: Carlo Palmieri (University of Liverpool, United Kingdom) and Ruth Keri (Cleveland Clinic, United States)
7:30 pm - 7:50 pm
Carol Lange (University of Minnesota, United States)
"Glucocorticoid Receptors Act as Cellular Stress Sensors in Triple Negative Breast Cancer"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Himisha Beltran (Dana Farber Cancer Institute, United States)
"Emerging Biomarkers to Detect Phenotypic Subtypes of Advanced Prostate Cancer"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Elgene Lim (Garvan Institute of Medical Research, Australia)
"Clinical Trials in Hormone-Related Cancers"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Amina Zoubeidi (University of British Columbia, Canada)
"ASCL1: A Bridge Between Cell Surface Receptor and The Epigenome to Support Lineage Plasticity in Prostate Cancer"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Defining and Addressing the Next Big Question in Hormone-Related Cancers
Discussion Leader: Luca Magnani (Imperial College London, United Kingdom)
9:00 am - 9:40 am
Lucas Brand (American Association for Cancer Research, United States)
"New Ways of Authoring in the Digital Age"
9:40 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Introduction by Discussion Leader
10:50 am - 11:00 am
General Discussion
11:00 am - 11:20 am
Daniel Gioeli (University of Virginia, United States)
"Alternative Mechanisms for the Clinical Benefit of Combining Androgen Deprivation Therapy with Radiation Therapy for Prostate Cancer"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Nicholas Larocque (University of California, San Francisco, United States)
"Next Big Question"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Sean Fanning (Loyola University Chicago, United States)
"What's Next for Estrogen Receptor?"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Translating Novel Targets in Hormone-Related Cancers into the Industry Setting
Discussion Leaders: Jennifer Richer (University of Colorado Anschutz Medical Campus, United States) and Massimo Loda (NewYork-Presbyterian/Weill Cornell Medical Center, United States)
7:30 pm - 7:50 pm
Scott Tomlins (Strata Oncology / University of Michigan, United States)
"Translating the Cancer Genome to the Clinic"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Ciara Metcalfe (Genentech, United States)
"Putting the Squeeze on Breast & Prostate Cancers with Next-Generation Hormone-Receptor Therapeutics."
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Melissa Junttila (ORIC Pharmaceuticals, United States)
"The Fate of Prostate Cancer Cells Treated With PRC2 Inhibitors"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Introduction by Discussion Leader
9:10 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure