| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:45 pm | Welcome / Introductory Comments by GRC Site Staff and Conference Chair |
| 7:40 pm - 9:00 pm | OPENING KEYNOTE & LANDSCAPE-SETTING TALKS |
| Chair & Discussion Leader: James R. Lupski (Baylor College of Medicine) |
| 7:40 pm - 7:45 pm | Welcome and Introductory Remarks |
| 7:45 pm - 8:30 pm | Opening Keynote: Helen Hobbs (University of Texas Southwestern Medical Center)
"Going to Extremes to Understand Common Diseases" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:10 pm | Peggy Pericak-Vance (University of Miami)
"The Genetics of Alzheimer Disease: What's hot, what's real, what's not" |
| 9:10 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | HUMAN GENETIC DISEASE - FROM MENDEL TO COMPLEX TRAITS |
| Session Chair & Discussion Leader: Aravinda Chakravarti (Johns Hopkins) |
|
9:00 am - 9:25 am | Nicholas Katsanis (Johns Hopkins)
"An Integrated View of the Genetic Basis of Ciliopathies" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:55 am | Ying-Hui Fu (University of California, San Francisco)
"Duplications of Lamin B1 Gene Cause Adult-Onset Leukodystrophy" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Coffee Break / Group Photo (10:15 am) |
|
10:30 am - 10:55 am | Art Beaudet (Baylor College of Medicine)
"Genome-Wide Epigenetic Analysis of Autism Brain Versus Control Brain" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 11:25 am | Julie van der Zee (University of Antwerp)
"Finding a Simple Gene within a Complex Genomic Region: The Progranuline Story in Frontotemporal Dementia" |
| 11:25 am - 11:30 am | Discussion |
| 11:30 am - 11:55 am | James R. Lupski (Baylor College of Medicine)
"Mechanisms for Rearrangements Causing Genomic Disorders" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | HUMAN EVOLUTIONARY GENETICS |
| Session Chair & Discussion Leader: Andrew G. Clark (Cornell University) |
| 7:30 pm - 7:55 pm | David Reich (MIT, Harvard)
"Multiple Regions within 8q24 Independently affect Risk for Prostate Cancer" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:25 pm | Pardis Sabeti (Broad Institute)
"Genome-Wide Detection and Characterization of Positive Selection in Human Populations" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:55 pm | Andrew G. Clark (Cornell University)
"Genome-Wide Inference of Time to Most Recent Common Ancestry" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:25 pm | Sarah Tishkoff (University of Maryland)
"Genetic Variation and Adaptation in Africa: Implications for Human Evolution and Human Disease" |
| 9:25 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | HUMAN CHROMOSOME BIOLOGY AND GENOME DYNAMICS |
| Session Chair & Discussion Leader: Robert D. Wells (Institute of Biosciences and Technology, Texas A&M) |
| 9:00 am - 9:25 am | Huntington Willard (Duke University)
"The Role of the Genome in Epigenetic Phenomena" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:55 am | Barbara Trask (Fred Hutchinson Cancer Research Center)
"Subtelomeric Dynamics" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:25 am | Vivian Cheung (University of Pennsylvania)
"Genetics of Variation in Human Gene Expression" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:25 am | John Moran (University of Michigan)
"RNA-Mediated DNA Repair by LINE-1 Retrotransposition" |
| 11:25 am - 11:30 am | Discussion |
| 11:30 am - 11:55 am | Evan Eichler (HHMI, University of Washington)
"Impact of Human Genome Duplication Architecture" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | BEYOND THE HUMAN HAPMAP - LINKS BETWEEN PHENOTYPE AND GENOTYPE |
| Session Chair & Discussion Leader: Richard Gibbs (Baylor College of Medicine) |
| 7:30 pm - 8:00 pm | David Altshuler (Broad Institute)
"Whole Genome Association Analysis of Type 2 Diabetes and other Diseases" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Manolis Dermitzakis (Sanger Institute)
"Population Genomics of Human Gene Expression" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | John Belmont (Baylor College of Medicine)
"High Throughput Genotyping of Mutations known to cause Mendelian Genetic Diseases" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | NEW GENOME TECHNOLOGIES |
| Session Chair & Discussion Leader: Eric Green (NHGRI) |
| 9:00 am - 9:25 am | Tom Gingeras (Affymetrix)
"Genome-Wide Maps of the Human Transcriptome Reveal an Interleaved Organization and Novel Short and Long Classes of RNAs" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:55 am | David Bentley (Illumina UK)
"The Potential Impact of New Sequencing Technology on Genomics" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:25 am | Richard Gibbs (Baylor College of Medicine)
"Functional Mutation Discovery (FMD) Project" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:25 am | Eric Green (National Human Genome Research Institute, NIH)
"Inter- and Intra-Species Sequence Comparisons: Deducing Genome Function in Health and Disease" |
| 11:25 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Abstract Talk: Jonathan Rothberg (Raindance Technologies)
"Technology progress and the quest for personal genomes: The Genome of James D. Watson" |
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Abstract Talk: David Schwartz (University of Wisconsin-Madison)
"Human Genome Structural Alteration Discerned by Single Molecule Analysis" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session III |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | GENOME STRUCTURAL VARIATION AND PHENOTYPE |
| Session Chair & Discussion Leader: Nigel P. Carter (Wellcome Trust, Sanger Institute) |
| 7:30 pm - 7:55 pm | Sunil Ahuja (UT Health Science Center San Antonio)
"Human Genes and HIV/AIDS Pathogenesis: Lessons from Nature" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:25 pm | Robert D. Wells (Institute of Biosciences and Technology, Texas A&M)
"Non-B DNA Conformations Promote Genomic Rearrangements by Defining the Breakpoints" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:55 pm | Nigel Carter (Sanger Institute)
"Disease and CNVs" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Abstract Talk: Jonathan Sebat (Cold Spring Harbor Laboratory)
"Genome-Wide Analysis Copy Number Variation in Autism" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Abstract Talk: Tara Matise (Rutgers University)
"Genomic Characterization of Schizophrenia Candidate Gene Regions" |
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | MOLECULAR GENETICS AND THERAPEUTICS OF HUMAN GENETIC DISEASE |
| Session Chair & Discussion Leader: John Belmont (Baylor College of Medicine) |
| 9:00 am - 9:25 am | Michael R. Green (University of Massachusetts Medical School)
"Studying Cancer Molecular Biology Using Genome-Wide RNA Interference Screens" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:55 am | Mark Kay (Stanford University)
"Gene and RNAi-based Therapeutics for Treating Human Disease" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:25 am | Steve Warren (Emory University)
"Fragile X Syndrome: Therapeutic Developments" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:25 am | Hal Dietz (Johns Hopkins)
"Marfan Syndrome and Related Disorders: From Molecules to Medicines" |
| 11:25 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Abstract Talk: Miriam Meisler (University of Michigan)"Human CMT4G and Mouse Models with Novel Mutations Affecting Endosomal Vesicles and PI(3,5)P2" |
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Abstract Talk: Antony Rodriguez (Wellcome Trust Sanger Institute)
"miR-155/bic is Essential for Normal Immune Function" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session IV |
| 6:00 pm | Dinner |
| 7:30 pm - 9:00 pm | CLOSING KEYNOTE TALK |
| Session Chair & Discussion Leader: Evan Eichler (HHMI, University of Washington) |
| 7:30 pm - 8:30 pm | Closing Keynote: Aravinda Chakravarti (Johns Hopkins)
"How Many Genes for a Complex Disease?" |
| 8:30 pm - 9:00 pm | General Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
