Human genetics is in the midst of a revolution. With the complete sequencing of several human genomes and the exponential decrease in the cost of whole-genome sequencing, the promise of individual genome sequencing is imminent. Despite these advances, a large fraction of the genetic variation underling human disease and phenotypic variation remains unexplained. This Gordon Conference will bring together international leaders in the field of human genetics and genomics to discuss what has been learned and where the field is heading. Speakers will summarize the major advances in our understanding of the organization and function of our genome, discuss new insights into human genetic diversity and highlight the application of new sequencing technologies. A particular focus of the meeting will be the development of appropriate frameworks for the interpretation of whole-genome sequence data and for elucidating the biological effects of pathogenic variants. The conference should be of interest to researchers and students in the fields of human and medical genetics as well as those interested in genome biology in the post-genomic era. It will also provide a venue for rapid exposure to the "state of the art" for investigators contemplating studies, or the utilization of tools, in this field.