Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Learning from Large Cohorts
7:40 pm - 8:10 pm
"Genomic Newborn Screening in the UK"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Powering Genomic Research through All of Us"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"All of Us Genetic Return of Results"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mendelian Genetics and Clinical Implementation
9:00 am - 9:30 am
"Investigating the Complex Relationship Between Genotypes and Disease Phenotypes"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Use of Optical Genome Mapping and Long-Read Sequencing to Solve Unsolved Rare Phenotypes."
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:30 am
"Functional Studies of Disease Associated Genes and Rare Variants Using the State-of-the-Art Genetic Technology in Drosophila melanogaster "
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Variants of Uncertain Significance: From Reporting to Individual Patients to Evaluation by ClinGen"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Use of Human Genetics in Drug Development
7:30 pm - 8:15 pm
"Drug Discovery in the Era of Genomics"
8:15 pm - 8:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Statistical Methods Using Large Data Sets
9:00 am - 9:25 am
"Large-Scale Inference Across Population Cohorts Identifies Novel Therapeutic Target Opportunities"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Using Human Genetics to Develop Therapies"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Genetic Analyses at Scale Using Biobanks"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
"UCLA SwabSeq COVID-19 NGS Diagnostic: The Bench to Vending Machine Adventure"
11:40 am - 11:50 am
Discussion
11:50 am - 12:15 pm
"Haplotype-Informed Discovery of Hidden Genetic Variants Influencing Human Traits"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Treatments for Rare Genetic Diseases
7:30 pm - 8:15 pm
"Treating Rare Genetic Diseases: Challenges and Opportunities"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
"n-Lorem: A Non-Profit Model for Translating Advanced Therapeutics to Nano-Rare Patients."
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Population Genetics Using Large Data Sets
9:00 am - 9:25 am
"The Diverse Genomic Architecture of the Developmental Continuum from Fetal Anomalies to Childhood Onset Disorders"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Testing for differences in polygenic scores in the presence of confounding"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"The Evolution and Heritability of Mammalian Mutation Rates"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
"Variant-Centric Perspectives on Human Population Structure and Implications for Study Design"
11:40 am - 11:50 am
Discussion
11:50 am - 12:15 pm
"Nationwide Genomic Biobank in Mexico Unravels Demographic History and Complex Trait Architecture from 6,057 Individuals"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genetics of Structural Anomalies
7:30 pm - 8:15 pm
"Functional Assessment of Noncoding Variants in Congenital Heart Disease"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
"Two Sides of the Same Coin: Analyses Across Developmental Disorders"
9:15 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Genome Function and Regulation
9:00 am - 9:25 am
"Interpretation of cis -Regulatory Information in the Genome"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Detecting CNVs in cancer and normal tissues from RNA data"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"In Vivo Studies of Human Genome Function"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
11:40 am - 11:50 am
Discussion
11:50 am - 12:15 pm
"Polygenic Contributions to Human Diseases and Their Mechanisms"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Power of Diverse Population Cohorts
7:30 pm - 8:15 pm
"Genomics of Drug Discovery"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
"Population genetics in an era of genomic health."
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure