| SATURDAY |
| 1:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Session |
| Discussion Leader: Hinco Gierman (Stanford University, Stanford, CA, USA) |
| 3:45 pm - 4:15 pm | Keynote: Barbara Stranger (The University of Chicago, Chicago, USA)
"Genomics of human gene expression and its use in deciphering complex trait biology" |
| 4:15 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session I (author last names A-O) |
| 6:00 pm | Dinner |
| 7:30 pm - 8:45 pm | GWAS & Beyond |
| Discussion Leaders: Hinco Gierman (Stanford University, Stanford, CA, USA) and Clint Miller (Stanford University, Stanford, CA, USA) |
| 7:30 pm - 7:40 pm | Joris Deelen (Leiden University Medical Center, Leiden, The Netherlands)
"Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age" |
| 7:40 pm - 7:45 pm | Discussion |
| 7:45 pm - 7:55 pm | Towfique Raj (Harvard Medical School / Brigham and Women's Hospital, Boston, MA, USA)
"Expression QTL analysis from primary immune cells of a multi-ethnic cohort identifies novel disease-causing regulatory effects" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:10 pm | Jeremy Sabourin (University of North Carolina, Chapel Hill, NC, USA)
"Analysis of GWAS hit regions with Resample Model Averaging: beyond additivity" |
| 8:10 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:25 pm | Scott Hebbring (Marshfield Clinic Research Foundation, Wisconsin, WI, USA)
"PheWAS - A novel method that combines genetics and medical informatics" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Break |
| 8:45 pm - 9:30 pm | Elucidating Functional Variants |
| Discussion Leaders: Towfique Raj (Harvard Medical School / Brigham and Women's Hospital, Boston, MA, USA) and Jeremy Sabourin (University of North Carolina, Chapel Hill, NC, USA) |
| 8:45 pm - 8:55 pm | Clint Miller (Stanford University, Stanford, CA, USA)
"Disease-relevant pathways modulate a cis-regulatory element at the TCF21 coronary heart disease locus" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Dorothee Diogo (Harvard Medical School / Brigham and Women's Hospital, Boston, MA, USA)
"Potential of integrating human genetics and electronic medical records for drug discovery: the example of TYK2 and rheumatoid arthritis"
|
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Jennifer Kulzer (University of North Carolina, Chapel Hill, NC, USA)
"Dysregulation of ARAP1 expression at a type 2 diabetes GWAS locus on 11q13.4 influences insulin secretion in the pancreatic beta cell"
|
| 9:25 pm - 9:30 pm | Discussion |
| 9:30 pm - 11:30 pm | GRS Social Event |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 10:15 am | NextGen Sequencing for Genetic Discovery |
| Discussion Leaders: Mark Kaganovich (Stanford University, Stanford, CA, USA) and Slave Petrovski (Duke University, Durham, NC, USA) |
| 9:00 am - 9:10 am | Meredith Carpenter (Stanford University, Stanford, CA, USA)
"Pulling out the 1%: whole-genome capture for the targeted enrichment of ancient DNA sequencing libraries" |
| 9:10 am - 9:15 am | Discussion |
| 9:15 am - 9:25 am | Laurent Francioli (University Medical Center Utrecht, Utrecht, The Netherlands)
"De novo mutations in the Genome of the Netherlands" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:40 am | Justin Cotney (Yale School of Medicine, New Haven, CT)
"The evolution of human-specific regulatory functions in the embryonic limb" |
| 9:40 am - 9:45 am | Discussion |
| 9:45 am - 9:55 am | Anna Stittrich (Institute for Systems Biology, Seattle, WA, USA)
"Family genomics reveals disease genetics" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Break |
| 10:15 am - 11:00 am | Clinical Application of NGS & Genomics |
| Discussion Leaders: Anna Stittrich (Institute for Systems Biology, Seattle, USA) and Meredith Carpenter (Stanford University, Stanford, CA, USA) |
| 10:15 am - 10:25 am | Mark Kaganovich (Stanford University, Stanford, CA, USA)
"SNP co-variance signatures in tumor genomes" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am - 10:40 am | Slave Petrovski (Duke University, Durham, NC, USA)
"A genome-wide ranking of genic intolerance to functional variation facilitates predicting disease causing genes and interpreting personal genomes" |
| 10:40 am - 10:45 am | Discussion |
| 10:45 am - 10:55 am | Jelena Belic (Institute of Human Genetics, Austria)
"Analysis of plasma DNA using whole genome sequencing in patients with prostate cancer" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session II (author last names P-Z) |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Mentorship component |
| Discussion Leaders: Jennifer Kulzer (University of North Carolina, Chapel Hill, NC, USA) and Joris Deelen (Leiden University Medical Center, Leiden, The Netherlands) |
| 1:30 pm - 2:15 pm | Magdalena Skipper (senior editor for Nature, London, UK)
"How to get published in a high-impact journal" |
| 2:15 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill out GRS Evaluation Forms |
| 3:00 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |
