| Saturday |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Session: Exploring Genetic Variation in Single Cells |
| Discussion Leaders: Harrison Brand (Harvard Medical School / Massachusetts General Hospital, USA) and Kaitlin Samocha (Massachusetts General Hospital, USA) |
| 3:45 pm - 4:15 pm | Steve McCarroll (Harvard Medical School, USA)
"Genetic Variation, Mental Illness, and the Biology of Thousands of Individual Cells" |
| 4:15 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Extending the Interpretation of the Exome / Noncoding Genomics: Beyond the Exome |
| Discussion Leaders: Seth Ament (Institute for Systems Biology, USA) and Tara Doucet (Johns Hopkins University School of Medicine, USA) |
| 7:30 pm - 7:35 pm | Introduction by Discussion Leader |
| 7:35 pm - 7:50 pm | Fah Sathirapongsasuti (23andMe, USA)
"A Polygenic Burden of Rare Variants in Extracellular Matrix Genes Among Individuals with Adolescent Idiopathic Scoliosis" |
| 7:50 pm - 7:55 pm | Discussion |
| 7:55 pm - 8:10 pm | Kart Tomberg (University of Michigan, USA)
"Mapping Thrombosis Modifier Genes by Bulk Exome Sequencing of Mice from a Sensitized ENU Mutagenesis Screen" |
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:35 pm | Kaitlin Samocha (Massachusetts General Hospital, USA)
"Inferring Functional Constraint from Large-Scale Human Variation Data" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:00 pm | Isis Ricaño-Ponce (University Medical Center Groningen, The Netherlands)
"SNPs Associated with Immune-Mediated Diseases Modulate the Expression of lncRNAs Involved in Inflammatory Processes" |
| 9:00 pm - 9:05 pm | Discussion |
| 9:05 pm - 9:20 pm | Lindsay Horvath (Johns Hopkins University, USA)
"Polymorphic Alu Insertions with Functional Consequences May Be the Causative Variant Identified in GWAS" |
| 9:20 pm - 9:30 pm | Discussion |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Alternative Approaches Beyond the Exome |
| Discussion Leaders: Anand Kumar Andiappan (Singapore Immunology Network (SIgN), A*STAR, Singapore) and Joanne Cole (University of Colorado, Anschutz Medical Campus, USA) |
| 9:00 am - 9:15 am | Seth Ament (Institute for Systems Biology, USA)
"A Transcriptional Regulatory Basis for Brain Disease" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Nicole Griffin (Columbia University, USA)
"Gene Expression Profiling in Dentate Granule Cells of Mesial Temporal Lobe Epilepsy Patients With and Without Hippocampal Sclerosis" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Sali Farhan (Robarts Research Institute, Canada)
"Tackling Neurodegeneration Using Next-Generation Sequencing: Identifying the Genetic Basis of Five Neurodegenerative Disorders" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Lisa Harney (The University of Iowa, USA)
"The Role of Copy Number Losses in Non-Syndromic Clefting" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Gabriel Haller (Washington University, USA)
"Drug Target Validation by Phenome-Wide Association Studies" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 10:55 am | K. Melodi McSweeney (Columbia University, USA)
"Microelectrode Array Captures Seizure-Like Activity Due to Down-Regulation of MicroRNA-128" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Where Do We Go from Here? / Mentorship Component: Scientific
Publishing |
| Discussion Leaders: Britney Helling (University of Colorado, Denver - Anschutz Medical Campus, USA) and Sali Farhan (Robarts Research Institute, Canada) |
| 1:30 pm - 1:40 pm | Bibiana Wong (Baylor College of Medicine, USA)
"Novel Functional and Genomic Approaches to Decipher the Cause of Aicardi Syndrome" |
| 1:40 pm - 1:45 pm | Discussion |
| 1:45 pm - 2:25 pm | Lara Szewczak (Cell, USA)
"Let's Talk! Communication and the Publication Process" |
| 2:25 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
