Deciphering Genomic Function to Understand Human Biology and Disease

The challenge facing the next era of human genetics research is to fully understand the vast amounts of genomic data that have been gathered over the recent decade and to apply this data to functionally annotate the genome with contributions to human biology and disease. This information is required to strengthen our understanding of both Mendelian and complex genetic disorders. Meeting such a challenge will require a nuanced approach to studying gene function and regulation, discovering how variants of variable effect size impact human physiology, and translating this knowledge into therapeutic targets and improved patient care. This Seminar will highlight innovative computational and experimental approaches to deciphering the effect of human variation on biology and disease, and how we might leverage these findings into improved therapeutics and patient care.