Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | IGF and Insulin System in Aging |
| Discussion Leader: Cunming Duan (University of Michigan, USA) |
7:40 pm - 8:40 pm | Andrzej Bartke (Southern Illinois University, USA) "Somatotropic Axis and Aging: Surprising Benefits of Endocrine Defects" |
8:40 pm - 9:10 pm | Discussion |
9:10 pm - 9:30 pm | General Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Aging |
| Discussion Leader: Marc Tatar (Brown University, USA) |
9:00 am - 9:25 am | Nir Barzilai (Albert Einstein College of Medicine, USA) "Role of the GH/IGF1 Axis in Exceptional Longevity" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Yousin Suh (Albert Einstein College of Medicine, USA) "Functional
Genomics of Aging" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Coleen Murphy (Princeton University, USA) "Insulin Signaling in the Regulation of Age-Related Declines" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Martin Holzenberger (INSERM UMRS 938, France) "IGF-1R Signaling in Aging and Age-Related Disease" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Selected from Poster Abstracts: Simon Johnson (Albert Einstein College of Medicine, USA) "Genetic variation in Insulin/IGF1/mTOR genes modulates human lifespan" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Selected from Poster Abstracts: Albert Chen (University of Michigan Medical School, USA) "Hierarchical Action of DAF-16/FoxO Isoforms in Life Span Control" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Molecular Mechanisms Underlying IGF and Insulin Action |
| Discussion Leader: Pierre De Meyts (De Meyts R&D Consulting, Belgium) |
7:30 pm - 7:55 pm | Michael Lawrence (Walter and Eliza Hall Institute, Australia) "New Insights Into the Way in Which Insulin Engages its Receptor - An Unfolding Story" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Daniel Leahy (Johns Hopkins University School of Medicine, USA) "Molecular Mechanisms Governing IGF1R Activity" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Selected from Poster Abstracts: Julian Weghuber (Upper Austria University of Applied Science, Austria) "Analysis of Insulin Receptor Substrate (IRS) Signaling Dynamics on Micro-Structured Surfaces" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Selected from Poster Abstracts: Lenka Zakova (Institute of Organic Chemistry and Biochemistry, Czech Republic) "Insight into the Structural and Biological Relevance of the T/R Transition of the N-Terminus of the β-Chain in Human Insulin" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | IGF and Insulin Signaling in Growth, Metabolism
and Disease |
| Discussion Leader: Antonino Belfiore (University of Catanzaro, Italy) |
9:00 am - 9:25 am | Andreas Hoeflich (Institute for Genome Biology, Germany) "IGF System, Metabolism and Diabetes" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Norbert Tennagels (Sanofi Diabetes, Germany) "Metabolic and Mitogenic Signaling of Insulin Analogs" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:00 am | Shoshana Yakar (New York University College of Dentistry, USA) "GH/IGF Axis in Bone: New Discoveries" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Selected from Poster Abstracts: Buel Rodgers (Washington State University, USA) "Revising a 43 Year Old Model of Vertebrate Growth Control Through the Novel Actions of Myostatin" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:00 pm | Friedrich Metzger (F. Hoffmann-La Roche Ltd., Switzerland) "The Therapeutic Potential for PEG-IGF-I in Spinal Muscular Atrophy with Respiratory Distress Type 1" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Selected from Poster Abstracts: Wenbiao Chen (Vanderbilt University School of Medicine, USA) "Modeling Type 2 Diabetes in Zebrafish with Insulin Resistance and Overnutrition" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | IGF-II and the IGF2R |
| Discussion Leader: Bass Hassan (University of Oxford, United Kingdom) |
7:30 pm - 7:55 pm | Andrew Hoffman (Stanford University, USA) "Long Noncoding RNAs, Looping and the IGF System" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Selected from Poster Abstracts: Susana Frago (University of Oxford, United Kingdom) "Evolution of an IGF2-TRAP" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Steven Levison (Rutgers University, New Jersey Medical School, USA) "IGF-II Is an Adult Intestinal Stem Cell Niche Factor" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Selected from Poster Abstracts: Wei Ge (The University of Macau, Macau SAR China) "IGF Regulation of Y-Box Binding Protein 1 (YB-1; Ybx1) in the Ovary: A Potential Mechanism of How the Growth Axis Influences Ovarian Follicle Activation" |
9:25 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | IGFs and Insulin in Cancer |
| Discussion Leader: Stephen Hursting (University of North Carolina, USA) |
9:00 am - 9:25 am | Douglas Yee (Masonic Cancer Center, University of Minnesota, USA) "Have We Learned Anything by Targeting IGF-IR in Cancer?" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Katia Scotlandi (Rizzoli Institute, Italy) "ERG Transcriptional Factor Activity in Prostate and Ewing Sarcoma and Effect on IGF-1R Expression" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Bo Hansen (Novo Nordisk, Denmark) "Insulin Analogues – Molecular Difference from Human Insulin – a Cause for Concern?" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Derek Leroith (Mount Sinai School of Medicine, USA) "The Importance of the Insulin/IGF-1 Receptors in Obesity-Related Cancer Risk" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Selected from Poster Abstracts: Rita Nahta (Emory University, USA) "Insulin-Like Growth Factor-1 Receptor Signaling Increases the Invasive Potential of HER2-Overexpressing Breast Cancer Cells via Modulation of FoxM1" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Selected from Poster Abstracts: Zhen Tang (University of Bristol, United Kingdom) "Insulin-Like Growth Factor Binding Protein 2 (IGFBP-2) Inhibits Growth, Invasion and Colony Formation of Bladder Cancer Cells" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | IGF Binding Proteins |
| Discussion Leader: Robert Baxter (Kolling Institute of Medical Research, Australia) |
7:30 pm - 7:50 pm | Janet Martin (University of Sydney, Australia) "Targeting IGFBP-3 Signaling Pathways as a Novel Therapy for Triple-Negative Breast Cancers" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Maria Grant (Indiana University, USA) "IGFs, IGFBPs and Diabetic Microvascular Complications" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Abhishek Kashyap (Queensland University of Technology, Australia) "Novel Approaches Targeting the IGF/Vitronectin/Integrin Axis in Cancer Progression: Proof-of-Concept Evidence" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Selected from Poster Abstracts: Malene Jepsen (Aarhus University, Denmark) "Stanniocalcin-2 Is a Novel Proteinase Inhibitor Regulating Mammalian Growth by Proteolytic Inhibition of the Insulin-Like Growth Factor Axis" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Neurological Diseases/Stem Cells/Progenitor Cells |
| Discussion Leader: Teresa Wood (Rutgers University, New Jersey Medical School, USA) |
9:00 am - 9:25 am | Paula Moreira (University of Coimbra, Portugal) "Insulin Signaling as a Bridge Between Diabetes and Alzheimer's Disease" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Cora O'Neil (University College Cork, Ireland) "Insulin
and IGF Signaling in Alzheimer’s Disease" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 10:55 am | Selected from Poster Abstracts: Heidemarie Kletzl (Hoffmann La Roche, Switzerland) "Pharmacokinetics, Pharmacodynamics, and Safety and Tolerability of a Novel Pegylated rhIGF-1 in Humans" |
10:55 am - 11:05 am | Discussion |
11:05 am - 11:20 am | Selected from Poster Abstracts: Bhumsoo Kim (University of Michigan, USA) "Beneficial Effect of IGF-I on Insulin Resistance-Induced Increases in Amyloid Precursor Protein and Tau Phosphorylation" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Selected from Poster Abstracts: Rudiger Schulz (Utrecht University, The Netherlands) "Igf3 Mediates Stimulatory Effects of Fsh on Spermatogenesis in Zebrafish" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Selected from Poster Abstracts: Zoltan Ungvari (University of Oklahoma, ROCA, USA) "IGF-1 Deficiency Impairs Neurovascular Coupling in Mice: Implications for Cerebromicrovascular Aging" |
12:15 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | IGF-1R and IR Signalling Pathways |
| Discussion Leader: Shin-Ichiro Takahashi (University of Tokyo, Japan) |
7:30 pm - 7:50 pm | Selected from Poster Abstracts: Gang Xi (University of North Carolina, Chapel Hill, USA) "Tissue Specific Knockout Reveals that IRS-1 but not IRS-2 Regulates Vascular Smooth Muscle Cell Differentiation and Loss of IRS-1 Results in a Marked Increase in Proliferation" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Selected from Poster Abstracts: Yosuke Yoneyama (University of Tokyo, Japan) "IRS-1 is a Negative Feedback Regulator of IGF-I Receptor Internalization via Interaction with AP-2 Clathrin Adaptor Complex" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Selected from Poster Abstracts: Barbara Addario (University College Cork, Ireland) "IGF-1R-associated protein complexes in cancer phenotype (EMT) and therapy resistance" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Linheng Li (Stowers Institute for Medical Research, USA) "Epigenetic Regulation of Igf2/Igfr Signaling Through Imprinting" |
9:20 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |