Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Regulation of IGF and Insulin Expression and Secretion
Discussion Leaders: Cunming Duan (University of Michigan, USA) and Claire Perks (University of Bristol, United Kingdom)
7:40 pm - 8:25 pm
Thomas Sudhof (Stanford University, USA)
"IGF-1 Exocytosis in Pancreas and Brain"
8:25 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
Anna Petrashen (Brown University, USA)
"Tissue-Specific Translational Regulation of Insulin-Like Growth Factor 1 by MYC"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
Joanna Stanicka (University College Cork, Ireland)
"The Adhesion Regulated FER Non-Receptor Tyrosine Kinase Enhances the Stability, Auto-Activation and Trafficking of IGF-1R"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
mTOR in IGF/Insulin Signaling and Nutrient Sensing
Discussion Leader: Derek Leroith (Icahn School of Medicine at Mount Sinai, USA)
9:00 am - 9:25 am
Michael Hall (Biozentrum, University of Basel, Switzerland)
"mTOR Signaling in Growth and Metabolism"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Kun-Liang Guan (University of California, San Diego, USA)
"Cross Talk Between mTOR and Hippo Pathways"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
John Blenis (Weill Cornell Medicine, USA)
"mTOR Regulation of mRNA Biogenesis, Metabolism and Cell Growth"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Pan Zheng (Children's National Medical Center, USA)
"Expansion of Innate Myelolymphoblastoid Effector Cells by Inactivation of mTOR Complex 1"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Guang Yang (The University of Sydney, Australia)
"Identifying Novel Regulatory Roles of Rag GTPases and Rapamycin on mTOR Complex1 Pathway"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Peter Stralfors (Linkoping University, Sweden)
"Insulin-Signaling Network, Normally and in Type 2 Diabetes - Mechanisms of Insulin Resistance"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Briony Forbes (Flinders Medical Centre, Flinders University, Australia) and Cheryl Conover (Mayo Clinic, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
IGF/Insulin Signaling
in Aging
Discussion Leader: Cheryl Conover (Mayo Clinic, USA)
7:30 pm - 7:55 pm
Diana Van Heemst (Leiden University Medial Center, The Netherlands)
"The Somatotropic Axis in Human Longevity and Old Age Survival"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Luigi Fontana (University of Brescia, Italy / Washington University in St. Louis, USA)
"Dietary Modulation of the Insulin/IGF-1 Pathway"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Pinchas Cohen (University of Southern California, USA)
"Interface Between the IGF System and Mitochondrial Biology"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Laurie Bale (Mayo Clinic, USA)
"Inducible Knock-Down of Pregnancy-Associated Plasma Protein-A Gene Expression in Adult Mice Extends Lifespan"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
IGF/Insulin Signaling in Cancer
Discussion Leader: Rosemary O'Connor (University College Cork, Ireland)
9:00 am - 9:25 am
Carlos Lopez-Otin (University of Oviedo, Spain)
"Loss of Proteostasis Causes IGF1R-Mediated Myeloid Transformation"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Emily Gallagher (Icahn School of Medicine at Mount Sinai, USA)
"Hyperinsulinemia and Breast Cancer Progression"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Jeff Holly (University of Bristol, United Kingdom)
"New Insights into the Role of IGFBPs in Human Cancers"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Thomas Bogenrieder (Boehringer Ingelheim RCV GmbH, Austria)
"Targeting the IGF Signaling Network with the IGF-1/-2 Ligand Neutralizing Antibody BI 836845"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Asia Matthew (University of Massachusetts Medical School, USA)
"Beclin 1 Regulates IGF1 and Insulin Signaling to Promote Breast Cancer Progression"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Alison Nagle (University of Pittsburgh, USA)
"A Proteomic Screen Reveals E-Cadherin as a Repressor of IGF1R Activity and a Potential Role for IGF1R in E-Cadherin-Low Breast Cancers"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
IGF Binding Proteins
Discussion Leader: Robert Baxter (University of Sydney, Australia)
7:30 pm - 7:55 pm
Yihong Wan (University of Texas Southwestern Medical Center, USA)
"IGFBP-1 Is a Pro-Osteoclastogenic Liver Hormone"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Wendie Cohick (Rutgers University, USA)
"Role for Nuclear IGFBP-3 in Intrinsic Apoptosis"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Lester Lau (University of Illinois at Chicago, USA)
"CCN1 in Wound Healing and Tissue Repair"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Rudiger Schulz (Utrecht University, The Netherlands)
"IGF Binding Proteins Protect Spermatogonia Against Excessive Differentiation in the Zebrafish Testis"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Neural Stem Cells, Neurological Diseases/Regeneration
Discussion Leader: John Pintar (Robert Wood Johnson Medical School, Rutgers University, USA)
9:00 am - 9:25 am
Terri Wood (New Jersey Medical School, Rutgers University, USA)
"Insulin and IGF Receptor Signaling in Neural Stem Cell Homeostasis"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Tzumin Lee (Janelia Research Campus, Howard Hughes Medical Institute, USA)
"Targets of IGF-II mRNA-Binding Protein in Neural Stem Cells"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Masahiro Tomioka (University of Tokyo, Japan)
"Role of the Insulin-Like Signaling Pathway in Learning in C. elegans "
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Zhigang He (Harvard University, USA)
"Differential IGF-1 Responses of Injured Neurons in the Adult CNS"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Tali Gidalevitz (Drexel University, USA)
"Misfolding of IGF Protein Induces Selective Neuronal Dysfunction Through a Bystander Mechanism"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Andreas Hoeflich (Leibniz-Institute for Farm Animal Biology, Germany)
"Phenotype Analysis of Transgenic Mice Overexpressing a Mutant IGFBP-2 Lacking the Cardin-Weintraub Sequence Motif: Reduced Expression of Synaptic Markers and Myelin Basic Protein in the Brain"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
IGF/Insulin Signaling in Metabolism, Growth, and Disease
Discussion Leader: Peter Rotwein (Texas Tech University Health Sciences Center at El Paso, USA)
7:30 pm - 7:55 pm
Thomas Clemens (Johns Hopkins University, USA)
"Bone Cell Bioenergetics and Skeletal Energy Homeostasis"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Hongxia Ren (Indiana University-Purdue University Indianapolis, USA)
"The FoxO1 Target Gene Gpr17 Regulates Appetite and Glucose Metabolism"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Francois Leulier (Universite de Lyon, France)
"Influence of the Intestinal Microbiota on Juvenile Growth and the GH/IGF-1 Axis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Gen He (Ocean University of China, China)
"Modulation of Nutritional Sensing and Its Applications in Aquaculture"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenetics
and Stem Cells/Cell Differentiation
Discussion Leaders: Briony Forbes (Flinders Medical Centre, Flinders University, Australia) and Linheng Li (Stowers Institute for Medical Research, USA)
9:00 am - 9:25 am
Marisa Bartolomei (University of Pennsylvania, USA)
"Regulation of Igf2 Imprinting During Development and Under Adverse Environmental Conditions"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Ning Dai (Harvard Medical School, USA)
"The Igf2 mRNA Binding Proteins in IGF2 Production and Action"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Marie-Liesse Asselin-Labat (The Walter and Eliza Hall Institute of Medical Research, Australia)
"Elucidating the Role of IGF-1 in the Regulation of Lung Stem Cells in Development and Disease"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
David Clemmons (University of North Carolina at Chapel Hill, USA)
"Role of IRS-1 in Regulating IGF-I and Insulin Induced Differentiation"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Colin Delaney (University of Michigan, USA)
"The Insulin-Like Peptide INS-9 Controls Stress-Induced Developmental Plasticity in C. elegans "
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
David Arnosti (Michigan State University, USA)
"Complex cis-Regulatory Landscape of the Insulin Receptor Gene"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: New Lessons from Model Organisms
Discussion Leaders: Andrzej Bartke (Southern Illinois University School of Medicine, USA) and Shin-Ichiro Takahashi (University of Tokyo, Japan)
7:30 pm - 7:45 pm
Chunyang Zhang (Indiana University Bloomington, USA)
"Drosophila as a Model for Metabolic Regulation During Oogenesis"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Jennifer Hill (University of Oregon, USA)
"Uncovering the Mechanism by Which a Conserved Bacterial Protein Induces Pancreatic Beta Cell Expansion"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Takafumi Miyamoto (Institute of Medical Science, University of Tokyo, Japan)
"Deconvoluting AMPK Dynamics"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
Gary Ruvkun (Harvard University, USA)
"C. elegans Surveillance of Core Cellular Components to Detect and Defend from Microbial Attacks"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure