Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: IGF and Insulin Signaling
Discussion Leaders: Shin-Ichiro Takahashi (University of Tokyo, Japan) and Claire Perks (University of Bristol, United Kingdom)
7:40 pm - 8:40 pm
C. Ronald Kahn (Joslin Diabetes Center, USA)
"New Insulin-Like Peptides and the Expanding Dimensions in Insulin/IGF Signalling"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Selected from Poster Abstracts: Lenka Zakova (Institute of Organic Chemistry and Biochemistry, ASCR, Czech Republic)
"Converting Insulin-Like Growth Factors 1 and 2 into High-Affinity Ligands for Insulin Receptor Isoform A by the Introduction of an Evolutionarily Divergent Mutation"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Selected from Poster Abstracts: Sarah Homberg (Helmholtz Zentrum München, Germany)
"IGF Receptor-Like 1 Is a Novel Regulator of the Insulin Signaling Pathway"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Structural Biology of the IGF and Insulin System
Discussion Leader: Pierre De Meyts (de Duve Institute, Belgium)
9:00 am - 9:25 am
Giovanna Scapin (Merck & Co., Inc., USA)
"Single Particle CryoEM Structure of the Insulin Receptor in Complex with Insulin"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Michael Lawrence (Walter and Eliza Hall Institute of Medical Research, Australia)
"IGF-1's Interaction with Its Receptor: Induced Fit or Lock-and-Key?"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Wolfgang Peti (University of Arizona, USA)
"Regulating Insulin Receptor Activity"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Danielle Robertson (University of Texas Southwestern Medical Center, USA)
"Demystifying the Role of IGF-1 and Insulin in the Cornea: Implications for Cellular Homeostasis"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Selected from Poster Abstracts: Briony Forbes (Flinders Medical Centre, Flinders University, Australia)
"Novel Insulin Analogues with Improved Therapeutics Benefits"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Emrah Altindis (Boston College, USA)
"Microbial Insulin Mimics in Type 1 Diabetes Autoimmunity"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizer: Briony Forbes (Flinders Medical Centre, Flinders University, Australia)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Host and Microbe Interactions
Discussion Leader: Martin Schwarzer (Institute of Microbiology, Czech Academy of Sciences, Czech Republic)
7:30 pm - 7:55 pm
Matthew Gill (Scripps Research, USA)
"Modulation of Life History Traits by a Truncated Insulin Receptor in C. elegans "
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Julia Charles (Brigham and Women's Hospital / Harvard Medical School, USA)
"Gut Microbiota, IGF-1 and Skeletal Growth"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Marc Tatar (Brown University, USA)
"Parsing the Regulatory Functions of Drosophila Insulin Paralogs: Distinct Roles in Metabolism and Aging Through Control of Glycogen Metabolism"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Masahiro Tomioka (University of Tokyo, Japan)
"The Function of Synaptic Insulin-Like Signaling in Behavioral Switch in C. elegans "
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Old and New IGF Binding Protein Biology
Discussion Leader: Wendie Cohick (Rutgers, The State University of New Jersey, USA)
9:00 am - 9:25 am
Madhulika Gupta (Children's Health Research Institute, Canada)
"Molecular Mechanisms Regulating IGFBP-1 Phosphorylation"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Jan Frystyk (Aarhus University Hospital, Denmark)
"The Stanniocalcin – PAPP-A – IGFBP-4 – IGF Axis: Clinical Findings and Perspective"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Robert Baxter (University of Sydney, Australia)
"IGFBP-3: At the Crossroads Between Cell Death and Survival"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Cunming Duan (University of Michigan, USA)
"Why IGF Binding Proteins and Why So Many?"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Selected from Poster Abstracts: Hanna Zielinska (University of Bristol, United Kingdom)
"Association Between GRP78 and IGFBP-3: Impact on the Prognosis for Patients with Triple-Negative Breast Cancer"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Adam Freund (Calico Life Sciences, USA)
"Transient Reduction of Local IGF-1 Signaling via PAPP-A Inhibition Is a Promising Target for Healthy Longevity"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The IGF Axis and Cancer
Discussion Leader: Emily Gallagher (Icahn School of Medicine at Mount Sinai, USA)
7:30 pm - 7:55 pm
Rosemary O'Connor (University College Cork, Ireland)
"IGF Activity in Mitochondrial Protection"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Adrian Lee (UPMC Hillman Cancer Center, USA)
"Modulators of IGF Signaling in Mammary Development and Breast Cancer"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Fumihiko Hakuno (The University of Tokyo, Japan)
"Roles of IRS-1-Induced Cell Competition in Myogenic Differentiation"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Rachel Barker (University of Bristol, United Kingdom)
"Hyperglycaemia Induces Epithelial to Mesenchymal Transition (EMT) in Prostate Cancer Cells: The Role of FOXA1 and IGFBP-2"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
IGF/Insulin System and Aging Related Diseases
Discussion Leader: Elisabeth Barton (University of Florida, USA)
9:00 am - 9:25 am
Kiran Pandey (New York University, USA)
"A Role of IGF2 in Memory Formation and Memory Enhancement"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
William Sonntag (University of Oklahoma Health Sciences Center, USA)
"Differential Effects of IGF-1 on Brain Aging and Age-Related Pathology"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Gonzalo Garcia (University of Michigan, USA)
"Enhanced Cap-Independence Translation in Slow Aging Mice Models with Low Levels of IGF"
11:05 am - 11:15 am
Discussion
11:15 am - 11:30 am
Selected from Poster Abstracts: Naoyuki Kataoka (Graduate School of Agriculture and Life Sciences, University of Tokyo, Japan)
"Rbfox2 Protein Mediates Exon 11 Inclusion in Insulin Receptor Alternative Splicing in Hepatoma Cells"
11:30 am - 11:35 am
Discussion
11:35 am - 11:50 am
Selected from Poster Abstracts: Alison Obr (Rutgers New Jersey Medical School, USA)
"Inhibition of IGF-1R in Wnt1-Mediated Mammary Tumorigenesis Alters the Tumor Microenvironment and Promotes Metastasis"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Selected from Poster Abstracts: Sarah Riis (University College Cork, Ireland)
"IGF-1 Signalling Promotes Mitochondrial Turnover and Protection in Cancer Cells"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Daiki Fujinaga (The University of Tokyo, Japan)
"Insect IGF-Like Peptide and Steroid Hormone Co-Ordinately Promote the Development of Insect Organs"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Stem Cell Biology
Discussion Leader: Teresa Wood (Rutgers New Jersey Medical School, USA)
7:30 pm - 7:55 pm
Quenten Schwarz (University of South Australia, Australia)
"Defining a Novel Angiocrine Role for IGF-1 in Craniofacial Development"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Joe Nguyen (University of Michigan, USA)
"Mammalian EAK-7 Activates Alternative mTOR Signaling"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Kenji Osafune (Kyoto University, Japan)
"Pancreatic Differentiation from Human iPSCs Towards Regenerative Therapy for Diabetes"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Takafumi Miyamoto (University of Tsukuba, Japan)
"Argininosuccinate Synthase 1 Is an AKT Repressor Transactivated by p53"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolic-Related Disorders
Discussion Leader: Andreas Hoeflich (Leibniz Institute for Farm Animal Biology, Germany)
9:00 am - 9:25 am
Stephen Simpson (The University of Sydney, Australia)
"Protein Leverage and the Nutritional Geometry of Obesity, Aging and Metabolic Health"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Jacqueline Stephens (Pennington Biomedical Research Center, USA)
"The Actions of Insulin and Growth Hormone and Metabolic Dysfunction in Adipose Tissue"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Shoshana Yakar (New York University College of Dentistry, USA)
"The Roles of IGF-1 in Hepatic Osteodystrophy"
11:05 am - 11:15 am
Discussion
11:15 am - 11:30 am
Selected from Poster Abstracts: Shady Younis (Uppsala University, Sweden)
"Functional Characterization of the Role of ZBED6-IGF2 Axis on the Growth of Skeletal Muscle and Internal Organs in Placental Mammals"
11:30 am - 11:35 am
Discussion
11:35 am - 11:50 am
Selected from Poster Abstracts: Kalina Biernacka (Translational Health Sciences, Bristol Medical School, University of Bristol, United Kingdom)
"Association Between IGF-I and Vitamin D Metabolism: A Novel Aspect in Population Data Analysis Pertaining to Vitamin D and Risk of Pca"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Selected from Poster Abstracts: Axel Goedecke (Heinrich Heine University Düsseldorf, Germany)
"IGF-1 Improves Cardiac Function After Myocardial Infarction by Modulating Myeloid Cells"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Na-Oh Yunn (Pohang University of Science and Technology, South Korea)
"Stepwise Autophosphorylation Modulates Biased Agonism of the Insulin Receptor"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Methodologies for IGF and Insulin Research
Discussion Leader: Victor Han (Children's Health Research Institute, Canada)
7:30 pm - 7:50 pm
Ünal Coskun (Paul Langerhans Institute Dresden, Germany)
"Lipid-Protein Interactions as Determinants for Controlled Cell Signaling Outcomes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Koseki Kobayashi-Kirschvink (University of Tokyo, Japan)
"Non-Destructive Prediction of Transcriptomic Profiles by Raman Microscopy"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Takeshi Murata (Chiba University, Japan)
"New Methodologies for Human Membrane Protein Crystallography"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Sean Megason (Harvard Medical School, USA)
"Mapping the Landscape of Zebrafish Development with Single Cell RNAseq"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure