(Feb 5) Monday Morning - 9:00 a.m. to 12:15 p.m.

Lymphocyte Development: Part I

• Diane Mathis, Discussion Leader
• Bernard Malissen, "Control of Pre-T cell Differentiatio"
• David Schatz, "The gd/ab T cell Split"

Monday Evening - 7:30 p.m. to 10:00 p.m.

Lymphocyte Development: Part II

• Frederick Alt, Discussion Leader
• Katia Georgeopoulos, "Duelling Fingers in Ikaros proteins"
• Marjorie Oettinger, "Biochemistry of V-D-J Recombination"

(Feb 6) Tuesday Morning - 9:00 a.m. to 12:15 p.m.

Cell Death in the Immune System

• Shigekazu Nagata, Discussion Leader
• Yuri Lazebnik, "Molecular Mechanisms of Cell Execution"
• Craig Thompson, "Differential Roles of Lymphokine and Bcl-2-Related Genes in Controlling Lymphocyte Survival"
• Tak Mak, "Thymocyte Negative Selection"

Tuesday Evening - 7:30 p.m. to 10:00 p.m.

Nonconventional Recognition by T cells

• Kirsten Fisher-Lindahl, Discussion Leader
• Michael Brenner, "Non-protein Antigen Presentation to T cells by CD1 Molecules"
• H. R. MacDonald , "Development and Function of NK1+ T cells"

(Feb 7) Wednesday Morning - 9:00 a.m. to 12:15 p.m.

Recognition by Natural Killer Cells

• Eric Long, Discussion Leader
• William Seaman, "Pathways of Inhibition Through NK Lectin-Like Receptors"
• Lewis Lanier, "Inhibitory MHC Receptors on Human NK and T Lymphocytes"
• David Raulet, "Development and Function of MHC-Specific NK Subsets"

Wednesday Evening - 7:30 p.m. to 10:00 p.m.

Costimulation of Lymphocytes

• Jeffrey Bluestone, Discussion Leader
• Arlene Sharpe, "Dissecting the In Vivo Function of the CD28/B7 Co-stimulatory Pathway Using B7-Deficient Mice"
• Garnett Kelsoe, "Role of Co-stimulation in the Development of Ig Hypermutation and T cell Memory"

(Feb 8) Thursday Morning - 9:00 a.m. to 12:15 p.m.

Antigen Presentation to T cells

• Antonio Lanzavecchia, Discussion Leader
• Per Peterson, "Class I Antigen Processing and Presentation"
• Dennis Zaller, "Role of HLA-DM in Antigen Processing"
• Ronald Germain, "Consequences of T cell Receptor Engagement by Variant MHC-Peptide Ligands"

Thursday Evening - 7:30 p.m. to 10:00 p.m.

AIDs

• Andrew McMichael, Discussion Leader
• Didier Trono, "Intracellular Trafficking in HIV Infection"
• George Shaw, "Viral Dynamics in HIV-1 Infection"

(Feb 9) Friday Morning - 9:00 a.m. to 12:15 p.m.

Signal Transduction / Transcriptional Activation

• Gerald Crabtree, Discussion Leader
• Victor Tybulewicz, "The Role of Vav and Syk in Lymphocyte: Development and Function"
• Dan Littman, "Tyrosine Kinases and Lineage: Specification in Thymocyte Development"
• Roger Perlmutter, "Distinct Signals Govern Positive and Negative Selection"