| SUNDAY |
| 4:00 pm - 8:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | B and T Cell Development |
| Discussion Leader: Meinrad Busslinger (Vienna Biocenter) |
| 7:30 pm - 8:00 pm | Katia Georgopoulos (Harvard University)
"Lymphocyte development through chromatin regulation" |
| 8:00 pm - 8:30 pm | Juan Carlos Zuniga-Pflucker (University of Toronto)
"Staging the molecular interactions that result in T cell differentiation" |
| 8:30 pm - 9:00 pm | Rudolph Grosschedl (Max-Planck-Institute for Immunobiology)
"Regulation of B cell development by EBF proteins" |
| 9:00 pm - 9:30 pm | Meinrad Busslinger (Vienna Biocenter)
"Control of B cell identity by Pax5" |
| 9:30 pm - 11:00 pm | Wine and Cheese Reception |
| MONDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Immune Cell Recognition |
| Discussion Leader: Mitchell Kronenberg (La Jolla Institute) |
| 9:00 am - 9:30 am | Mitchell Kronenberg (La Jolla Institute)
"Innate-type immune response to bacteria mediated by the NKT cell antigen receptor" |
| 9:30 am - 10:00 am | D. Branch Moody (Brigham & Women's Hospital)
"The surprising diversity of lipid antigens for T cells" |
| 10:00 am - 10:15 am | Frank Staal (Erasmus Medical Center)
"Wnt signaling in the thymus is regulated by differential expression of intracellular signaling molecules" |
| 10:15 am - 10:30 am | Henri de la Salle (INSERM)
"Endosomal CD1e-dependent processing, an obligatory step for the presentation of CD1-restricted glycolipids" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:30 am | Ian Wilson (Scripps Research Institute)
"TLR-3 structure and its implications for ligand binding and signaling" |
| 11:30 am - 11:45 am | Jens Derbinski (German Cancer Research Center)
"Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels" |
| 11:45 am - 12:15 pm | Max Cooper (University Alabama, Birmingham)
"Variable lymphocyte receptors in jawless vertebrates" |
| 12:45 pm | Photo / Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I (A - J) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Innate Immune Responses |
| Discussion Leader: Lewis Lanier (UCSF) |
| 7:30 pm - 8:00 pm | Lewis Lanier (UCSF)
"NK receptors in innate and adaptive immunity" |
| 8:00 pm - 8:30 pm | Olivier Voinnet (CNRS)
"RNA silencing: nucleic acid-based innate immunity" |
| 8:30 pm - 9:00 pm | William Seaman (UCSF)
"Mouse TIM-2 is a receptor for H-ferritin" |
| 9:00 pm - 9:30 pm | Francesco Colucci (Babraham Institute)
"Immunity to cancer and infections - alternative NK cell activation pathways" |
| TUESDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Immune Cell Activation |
| Discussion Leader: Doreen Cantrell (University of Dundee) |
| 9:00 am - 9:30 am | Doreen Cantrell (University of Dundee)
"Serine kinase networks in T lymphocytes" |
| 9:30 am - 10:00 am | Andre Veillette (IRCM)
"Immunoregulation by SAP family adaptors" |
| 10:00 am - 10:15 am | Jonathan Maltzman (University of Pennsylvania)
"Thymocyte selection in mice conditionally expressing SLP-76" |
| 10:15 am - 10:30 am | Kaushik Choudhuri (University of Oxford)
"T cell activation is critically dependent on the dimensions of the interaction between the T-cell receptor and pMHC" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:30 am | Jurg Tschopp (University of Lausanne)
"Activation of proinflammatory caspases" |
| 11:30 am - 11:45 am | Erin Adams (Stanford University)
"Structure of a gamma delta T cell receptor in complex with the non- classical MHC T22 reveals a new paradigm for antigen recognition" |
| 11:45 am - 12:15 pm | Warren Leonard (NHLBI/NIH)
"The biology of IL-21" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I (A - J) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Memory and Effector Function |
| Discussion Leader: Steven Reiner (University of Pennsylvania) |
| 7:30 pm - 8:00 pm | Steven Reiner (University of Pennsylvania)
"Specifying effector and memory T cell fate" |
| 8:00 pm - 8:30 pm | Rafi Ahmed (Emory University)
"Memory CD8 T cell differentiation during acute versus chronic viral infection" |
| 8:30 pm - 9:00 pm | Richard Flavell (Yale University)
"Epigenetic regulation of cytokine gene expression" |
| 9:00 pm - 9:30 pm | Susan Swain (Trudeau Institute)
"CD4 Memory: generation, persistence and protection" |
| WEDNESDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cell Positioning in the Immune System |
| Discussion Leader: Jason Cyster (UCSF) |
| 9:00 am - 9:30 am | Jason Cyster (UCSF)
"Sphingosine-1-phosphate and lymphocyte egress" |
| 9:30 am - 10:00 am | Takashi Nagasawa (Kyoto University)
"CXCL12 and regulation of HSC and B lymphocyte localization during development" |
| 10:00 am - 10:15 am | Susan Kaech (Yale University)
"Mapping memory CD8 T cell precursors" |
| 10:15 am - 10:30 am | Luis Sigal (Fox Chase Cancer Center)
"Memory CD8+ T cells protect from a peripheral infection with a lethal virus" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:30 am | Thomas Boehm (Max Planck Institute)
"Elaboration of the thymic microenvironment" |
| 11:30 am - 11:45 am | Nathalie Auphan-Anezin (INSERM)
"STAT5-mediated signals sustain a TCR-initiated gene expression program towards differentiation of CD8 T cell effectors" |
| 11:45 am - 12:15 pm | Dan Littman (NYU School of Medicine)
"The intestinal immune system: development and interaction with microbes" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II (K - Z) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | In vivo Imaging of Immune Responses |
| Discussion Leader: Ronald Germain (NIAID/NIH) |
| 7:30 pm - 8:00 pm | Ronald Germain (NIAID/NIH)
"In situ 4D imaging of immune cell behavior and function in lymphoid and peripheral tissues" |
| 8:00 pm - 8:30 pm | Matthew Krummel (UCSF)
"Multicellular dynamics of lymphocytes in vivo" |
| 8:30 pm - 9:00 pm | Sebastian Amigorena (Institute Curie)
"Antigen presentation and T cell activation by dendritic cells" |
| 9:00 pm - 9:30 pm | Ellen Robey (University California, Berkeley)
"Dynamics of thymocytes and T cells in tissue" |
| THURSDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Host/Pathogen Interactions |
| Discussion Leader: Anne O'Garra (NIMR) |
| 9:00 am - 9:30 am | Anne O'Garra (NIMR)
"Antigen-driven IL-10 producing regulatory T cells versus naturally occurring CD25+ regulatory T cells: implications for their roles in regulation of immune responses to pathogens" |
| 9:30 am - 10:00 am | Paul Klenerman (University of Oxford)
“T cell responses and persistent viruses - lessons from diverse human Infections” |
| 10:00 am - 10:15 am | Deborah Fowell (Center for Vaccine Biology & Immunology)
"Distinct TCR signal requirements for the gain and release of Th2 effector function" |
| 10:15 am - 10:30 am | Terry Fang (University of Pennsylvania)
"Notch signaling and helper T cell differentiation" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:30 am | Caetano Reis e Sousa (Cancer Research, UK)
“Innate activation of dendritic cells” |
| 11:30 am - 11:45 am | Ricardo Medeiros (University of Minnesota)
"Protein kinase D1 and the beta1 integrin cytoplasmic domain coordinately control beta1 integrin function and clustering via regulation of Rap1 activation and membrane localizations" |
| 11:45 am - 12:15 pm | Emil Unanue (Washington University)
“Lymphocyte apoptosis influences resistance to Listeria infection” |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II (K - Z) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Termination of Immune Responses |
| Discussion Leader: Fiona Powrie (University of Oxford) |
| 7:30 pm - 8:00 pm | Fiona Powrie (University of Oxford)
"Control of immune pathology by regulatory T cells" |
| 8:00 pm - 8:30 pm | Alexander Rudensky (University of Washington)
"Genetic mechanism of dominant tolerance" |
| 8:30 pm - 9:00 pm | Arlene Sharpe (Brigham & Women's Hospital)
"Role of pathways in the B7:CD28 family in regulating T cell tolerance and autoimmunity" |
| 9:00 pm - 9:30 pm | Michael Lenardo (NIAID/NIH)
"Coordinate molecular regulation of lymphocyte activation and programmed death" |
| FRIDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
