SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | MOLECULAR ASPECTS OF IMMUNE RECOGNITION |
| Discussion Leader: Mark Davis (Stanford University & HHMI, USA) |
7:40 pm - 8:00 pm | Mark Davis (Stanford University & HHMI, USA)
"T cells as a self-referential sensory organ" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Anton van der Merwe (Oxford, UK) "Molecular mechanism of TCR triggering" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Mike Dustin (NYU, USA)
"Modular construction of the immunological synapse" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | Gillian Griffiths (Cambridge, UK)
"Control of secretion at the immunological synapse" |
9:25 pm - 9:30 pm | Discussion |
MONDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | LYMPHOCYTE ACTIVATION AND SIGNAL TRANSDUCTION |
| Discussion Leader: Anjana Rao (Harvard, USA) |
9:00 am - 9:20 am | Anjana Rao (Harvard University, USA)
"Calcium signaling in lymphocyte activation" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Richard Lewis (Stanford University, USA)
"Molecular mechanism of CRAC channel regulation in T cells" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break / Group Photo |
10:30 am - 10:50 am | Kees Murre (UCSD, USA)
"Approaching the 3D-Structure of the Immunoglobulin Heavy Chain Locus" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Steve Reiner (University of Pennsylvania, USA)
"Specifying the varied T cell fates required for immunity" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Nilabh Shastri (U.C. Berkeley, USA) "The immunodominant response to Toxoplasma gondii requires antigen processing in the ER" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Karine Chemin (Institut Curie, France) "Role of myosin IIA in the immune synapse formation between human T cells and B cells" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Karsten Sauer (The Scripps Research Institute, USA) "Positive Regulation of Itk PH Domain Function by IP4 is Required for Thymocyte Positive But not Negative Selection" |
12:10 pm - 12:15 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | LYMPHOCYTE DEVELOPMENT |
| Discussion Leader: Cynthia Guidos (Toronto University, Canada) |
7:30 pm - 7:50 pm | Matthias Merkenschlager (Imperial College London, UK)
"Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Meinrad Busslinger (Research Inst. Molecular Pathology, Austria)
"Pax5 in the initiation and maintenance of B cell identity" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Cynthia Guidos (Toronto University, Canada) "Regulation of Notch signaling intensity and ligand specificity by Fringe proteins" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Harald von Boehmer (Harvard, USA)
"Intrathymic lineage fate decisions: lineage fate tracing and single cell analysis" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | INNATE IMMUNITY |
| Discussion Leader: Caetano Reis e Sousa (Cancer Research UK) |
9:00 am - 9:20 am | Jules A. Hoffmann (CNRS Strasbourg France)
"The antimicrobial defense of Drosophila: a paradigm for innate immunity" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Ruslan Medzhitov (Yale University & HHMI, USA)
"Cross-talk of innate immune signaling pathways" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Caetano Reis e Sousa (Cancer Research UK) "Innate recognition of self" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Jurg Tschopp (University of Lausanne, Switzerland) "The inflammasome" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Konstantina Alexandropoulos (Mount Sinai Med School, USA) "Regulation of thymic epithelial cell differentiation and T cell-mediated autoimmunity by the adapter Sin" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Daniel Stetson (University of Washington, USA) "Trex1 Prevents Cell Intrinsic Initiation of Autoimmunity" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Marie Anne O’Donnell (Mount Sinai Med School, USA) "TNF and RIG-I signaling pathways dovetail with the disappearance of the CYLD deubiquitinase" |
12:10 pm - 12:15 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | INNATE OR NATURAL MEMORY LYMPHOCYTES |
| Discussion Leader: Vincenzo Cerundolo (Oxford, UK) |
7:30 pm - 7:50 pm | Vincenzo Cerundolo (Oxford, UK) "Harnessing invariant NKT cells in vaccination strategies" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Laurent Gapin (National Jewish Medical Center, USA)
"Repertoire formation and antigen recognition by NKT cells" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Olivier Lantz (Institut Curie, France) "MAIT cell ontogeny" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Adrian Hayday (King's College, UK)
"Molecules mediating immunosurveillance of epithelia" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | LYMPHOCYTE DYNAMICS |
| Discussion Leader: Ellen Robey (UC Berkeley, USA) |
9:00 am - 9:20 am | Ron Germain (NIH, USA)
"Dynamic Intravital Imaging of Innate and Adaptive Immune Responses" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Facundo Batista (Cancer Research UK)
"Early events in B cell activation" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Ellen Robey (UC Berkeley, USA)
"Imaging T cells in the thymus and in the response to parasitic infections" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Philippe Bousso (Pasteur Institute, France)
"Cellular orchestration of T cell responses in vivo" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Cheong-Hee Chang (University of Michigan, USA) "Unique properties of CD4 T cells selected by MHC expressing thymocytes" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Yueh-Hsiu Chien (Stanford University, USA) "Thymic selection determines γδ T cell effector fate" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Toshinori Nakayama (Chiba University, Japan) "Regulation of memory Th2 cell survival and function by the Polycomb group and Trithorax group gene products" |
12:10 pm - 12:15 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | T CELL REGULATION AND INFLAMMATION |
| Discussion Leader: Dan Littman (NYU & HHMI, USA) |
7:30 pm - 7:50 pm | Dan Littman (NYU & HHMI, USA)
"Transcriptional regulation in Th17 cell differentiation" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Andrea Cooper (Trudeau Institute, USA)
"The role of IL-17 producing cells in vaccination and lung inflammation" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Hilde Cheroutre (La Jolla Institute Allergy & Immunology, USA)
"Reciprocal regulatory mechanisms between Th17 and regulatory T cells" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Alexander Rudensky (University of Washington & HHMI, USA) "Foxp3: a master regulator of T regulatory cell function" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | MUCOSAL IMMUNITY |
| Discussion Leader: Fiona Powrie (Oxford University) |
9:00 am - 9:20 am | Lora Hooper (Dallas Southwestern Medical Center, USA)
"Innate immune responses to commensal bacteria at the gut epithelial surface" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | David Artis (University of Pennsylvania, USA)
"Acquisition of commensal flora controls intestinal immune homeostasis" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Kevin Maloy (Oxford, UK)
"Pattern recognition receptors and immune pathogenesis of inflammatory bowel diseases" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Yasmine Belkaid (NIH, USA)
"Induction and regulation of Treg during parasitic infections" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Riitta Lahesmaa (University of Turku, Finland) "A novel mitochondrial regulator of human primary T helper cell apoptosis, Stat6 and Th2 cell differentiation" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Dominique Kaiserlian (INSERM-U851, France) "CD8 T cells: A novel therapeutic target in Crohn’s Disease" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Speaker TBA |
12:10 pm - 12:15 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm | Reception on the Cloisters Lawn |
6:00 pm | Formal Dinner |
7:30 pm - 9:30 pm | AUTOIMMUNITY |
| Discussion Leader: Ward Wakeland (Dallas Southwestern Medical Center, USA) |
7:30 pm - 7:50 pm | Ward Wakeland (Dallas Southwestern Medical Center, USA)
"Genetic interactions that drive systemic autoimmunity" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Rikard Holmdahl (Lund University, Sweden)
"Genetic control of autoimmune arthritis" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | David Hafler (Harvard, USA)
"Genetic Regulation of Organ Specific Autoimmune Disease" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Diane Mathis (Harvard, USA)
"Molecular controls on autoimmunity and inflammation" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am | Depart |