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Immunochemistry and Immunobiology

Gordon Research Conference

May 16 - 21, 2010
Chair Caetano Reis e Sousa
Vice Chair Cynthia J. Guidos
Les Diablerets Conference Center
Eurotel Victoria
Les Diablerets, Vaud (fr), Switzerland
 Venue and Travel Information

Conference Description

There probably is no tissue or organ with a greater impact on human health than the immune system. The last decades have seen an explosion of knowledge regarding the functioning of the immune system both in health and disease.The GRC on Immunochemistry and Immunobiology has been held regularly since 1966. Its small size and broad coverage of cutting edge Immunology distinguish it from larger conferences focussed on more specialised topics within the field. The 2010 GRC on Immunochemistry and Immunobiology will cover those areas of Immunology currently receiving the most intense investigation, both on the basic and applied front. The meeting will be divided into nine half-day sessions, with approximately 36 invited speakers who are internationally recognised for their contributions. Several slots will additionally be allotted for platform presentations selected from submitted abstracts. An intimate setting in the Swiss mountains, ample time for discussion and a maximum of 150 attendees will combine to favour an intense exchange of ideas and to help advance knowledge in the field. As usual, there will be poster sessions and many opportunities for informal interactions among participants throughout the week. Past GRCs on Immunochemistry and Immunobiology have been a great success and the 2010 meeting is likely to be oversubscribed. Early application is highly recommended.

Conference Program

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmINNATE IMMUNITY AND INFLAMMATION
Discussion Leader: Ruslan Medzhitov (Yale University & HHMI, USA)
7:40 pm - 8:00 pmMax Cooper (Emory Vaccine Centre, USA)
"Immune mechanisms in jawless vertebrates"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:30 pmJürg Tschopp (University of Lausanne, Switzerland)
"The inflammasomes: sensors of metabolic danger?"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:00 pmRuslan Medzhitov (Yale University & HHMI, USA )
"Innate control of adaptive immune responses"
9:00 pm - 9:05 pm Discussion
9:05 pm - 9:25 pmYasmine Belkaid (NIH, USA)
"Roles of retinoic acid in protective immunity"
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLYMPHOID STRESS-SURVEILLANCE RESPONSES
Discussion Leader: Adrian Hayday (London Research Institute, UK)
9:00 am - 9:20 amAdrian Hayday (London Research Institute, UK)
"Exploring the lymphoid stress-surveillance response"
9:20 am - 9:30 am Discussion
9:30 am - 9:40 am Claire Soudais (InstituteCurie, France)
"Anti-bacterial function of Mucosal Associated Invariant T cells"
9:40 am - 9:45 am Discussion
9:45 am - 9:55 am Marielle Gold (Oregon Health & Science University, USA)
"Human Mucosal Associated Invariant T cells Detect Bacterially Infected Cells"
9:55 am - 10:00 am Discussion
10:00 am Coffee Break / Group Photo
10:30 am - 10:50 amMitch Kronenberg (La Jolla Institute for Allergy & Immunology, USA)
"Innate-like responses to microbes by natural killer T cells"
10:50 am - 11:00 am Discussion
11:00 am - 11:10 amMichael Weinreich (University of Minnesota, USA)
"PLZF+ cells regulate the development of memory-like CD8 T cells through IL-4"
11:10 am - 11:15 am Discussion
11:15 am - 11:35 amEric Vivier (Luminy Centre for Immunology of Marseille, France)
"Activation of natural killer cells"
11:35 am - 11:45 am Discussion
11:45 am - 12:05 pmAngela Santoni (Sapienza University of Rome, Italy)
"NK cell recognition of drug-induced senescent tumor cells"
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Sylvia Cremer (University of Regensburg, Germany)
"Social immune memory in insect colonies"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session #1
5:30 pm - 7:30 pmLEUKOCYTE DEVELOPMENT
Discussion Leader: Cynthia Guidos (Toronto University, Canada)
5:30 pm - 5:50 pmJim P. Di Santo (Institut Pasteur, France)
"Roles for diverse NK cell subsets in tissue homeostasis and immune defense"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pmCindy Guidos (Toronto University, Canada)
"Functions of Notch signaling in T cell development and leukemogenesis"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pmMeinrad Busslinger (Research Institute of Molecular Pathology, Austria)
"Transcriptional networks controlling early B cell development"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pmHarinder Singh (The University of Chicago/Genentech, USA)
"Gene regulatory networks regulating B cell development and function"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmANTIGEN PRESENTATION AND LYMPHOCYTE ACTIVATION
Discussion Leader: Doreen Cantrell (University of Dundee, UK)
9:00 am - 9:20 amNilabh Shastri (UC Berkeley, USA)
"How the antigen presentation pathway interprets the genome"
9:20 am - 9:30 am Discussion
9:30 am - 9:40 am Jane Grogan (Genentech, USA)
"TIGIT is a T cell specific IGV receptor that negatively modulates T cell activation"
9:40 am - 9:45 am Discussion
9:45 am - 9:55 am Yolanda Carrasco (National Centre of Biotechnology, Spain)
"CXCR5 and BCR signalling fine-tune B cell dynamics and activation"
9:55 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Michael Reth (Max-Planck Institute of Immunobiology, Germany)
"Regulation and autoinhibition of the B cell antigen receptor on resting B cells"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 amJohannes Huppa (Stanford University School of Medicine, USA)
"Imaging T cell antigen recognition"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Nicole Boucheron (Medical University of Vienna, Austria)
"HDAC1 deficiency in T cells leads to enhanced allergic airway inflammation by regulating Th2 cytokine production"
11:40 am - 11:45 am Discussion
11:45 am - 12:05 pmDoreen Cantrell (University of Dundee, UK)
"Protein kinase B/Akt programs T cell migration and differentiation but is dispensable for metabolism"
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm John Hoerter (The Scripps Research Institute, USA)
"Agonist MHC avidity for CD8 defines the properties of activation enhancement by nonstimulatory peptides"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session #2
5:30 pm - 7:30 pmIMMUNE CELL INTERACTIONS
Discussion Leader: Marc Jenkins (University of Minnesota, USA)
5:30 pm - 5:50 pmMarc Jenkins (University of Minnesota, USA)
"How CD4+ T cells remember bacterial infections"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Michael Sixt (Max-Planck Institute of Biochemistry, Germany)
"Cytoskeletal dynamics of migrating leukocytes"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pmRon Germain (NIH, USA)
"Dynamic intravital imaging of immune cell behavior in lymphoid and peripheral tissues"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pm Ellen Robey (UC Berkeley, USA)
"Dynamic imaging of T cell behavior in situ"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGENERATION OF EFFECTOR LYMPHOCYTES
Discussion Leader: Gitta Stockinger (National Institute of Medical Research, UK)
9:00 am - 9:20 amEd Palmer (Basel University, Switzerland)
"Affinity thresholds in T lineage cells"
9:20 am - 9:30 am Discussion
9:30 am - 9:40 am Georgia Perona-Wright (Trudeau Institute, USA)
"Sustained signaling by canonical T helper cytokines throughout the reactive lymph node"
9:40 am - 9:45 am Discussion
9:45 am - 9:55 am Jennifer Gommerman (University of Toronto, Canada)
"Regulation of IgA synthesis in the intestinal lamina propria"
9:55 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 amGitta Stockinger (National Institute of Medical Research, UK)
"Modulation of effector T cell development"
10:50 am - 11:00 am Discussion
11:00 am - 11:10 amJonathan Coquet (Netherlands Cancer Institute, Netherlands)
"The CD27-CD70 co-stimulatory pathway inhibits Th-17 differentiation by impeding IL-17 transcription"
11:10 am - 11:15 am Discussion
11:15 am - 11:25 amElissa Deenick (Garvan Institute, Australia)
"The requirement for B cells in T follicular helper cell generation depends on antigen availability"
11:25 am - 11:30 am Discussion
11:30 am - 11:50 am David Voehringer (University of Munich, Germany)
"Orchestration of type 2 immunity by basophils and Th2 cells"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:10 pmHelena Paidassi (Harvard Medical School, USA)
"Apoptotic cells and intestinal immune homeostasis"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Mark Travis (University of Manchester, UK)
"A critical role for integrin-mediated TGF-beta activation by dendritic cells in the regulation of gut immune responses"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session #3
5:30 pm - 7:30 pmIMMUNE REGULATION AND DYSFUNCTION
Discussion Leader: Diane Mathis (Harvard, USA)
5:30 pm - 5:50 pmDiane Mathis (Harvard, USA)
"Control of immunological tolerance"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pmHilde Cheroutre (La Jolla Institute for Allergy & Immunology, USA)
"CD4 CTLs: omitting felony by switching fate"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pmFederica Sallusto (Institute for Research in Biomedicine, Switzerland)
"T cell migration in immunity and autoimmunity"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pmDan Littman (NYU, USA)
"A cryptic innate response to HIV in human dendritic cells"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
9:00 am - 12:30 pmIMMUNITY TO INFECTIONS
Discussion Leader: Antonio Lanzavecchia (Institute for Research in Biomedicine, Switzerland)
9:00 am - 9:20 am Antonio Lanzavecchia (Institute for Research in Biomedicine, Switzerland)
"The human antibody response to influenza virus"
9:20 am - 9:30 am Discussion
9:30 am - 9:40 am Ursula Hofer (University Hospital Zurich, Switzerland)
"Defective clearance of translocated bacterial products promotes HIV pathogenesis"
9:40 am - 9:45 am Discussion
9:45 am - 9:55 am Matteo Iannacone (Harvard Medical School, USA)
"Lymph Node Subcapsular Sinus Macrophages Prevent CNS Invasion Upon Peripheral Infection With a Neurotropic Virus"
9:55 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Andrea Cooper (Trudeau Institute, USA)
"The importance of immune cell location in expression of immunity in tuberculosis"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 amAnnette Oxenius (ETH, Switzerland)
"Antibody-mediated protection against intracellular bacterial pathogens"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Werner Held (Ludwig Institute for Cancer Research Ltd., Switzerland)
"Essential role of the canonical Wnt pathway for the establishment of functional CD8 T cell memory"
11:40 am - 11:45 am Discussion
11:45 am - 12:05 pmClaude-Agnès Reynaud (Faculty of Medicine Necker-Paris Descartes, France)
"Multiple memory B cell subsets in the mouse"
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Nico Ghilardi (Genentech, USA)
"L-27 promotes T-cell dependent colitis through restriction of regulatory T-cell differentiation"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session #4
5:30 pm - 7:30 pmTHE IMMUNE SYSTEM AT MUCOSAL SURFACES
Discussion Leader: Andrew Macpherson (University of Bern, Switzerland)
5:30 pm - 5:50 pmBart Lambrecht (Ghent University, Belgium)
"Activation of dendritic cells in asthma: the danger within"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pmLora Hooper (Dallas Southwestern Medical Center, USA)
"Commensal-host interactions at the mucosal surface"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pmAndrew Macpherson (University of Bern, Switzerland)
"Mutualistic mucosal immune responses to commensal intestinal microbes"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pm Fiona Powrie (University of Oxford, UK)
"Gut reactions: Immune pathways in the intestine in health and disease"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

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