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Immunochemistry and Immunobiology

Gordon Research Conference

June 10 - 15, 2012
Chair Cynthia J. Guidos
Vice Chair Adrian Hayday
Les Diablerets Conference Center
Eurotel Victoria
Les Diablerets, Vaud (fr), Switzerland
 Venue and Travel Information

Conference Description

The immune system has enormous impact on human health and well-being, This Gordon Research Conference on Immunochemistry and Immunobiology has been held regularly since 1966, but over the last few years there has been a huge increase in knowledge of immune functions in health and disease. Les Diablerets provides an intimate setting in the Swiss mountains for the 2012 GRC on Immunochemistry and Immunobiology, where a maximum of 150 participants will exchange ideas and discuss the latest advances in the field. In contrast to many conferences that focus on specialized Immunology topics, this 2012 GRC on Immunochemistry and Immunobiology will feature broad coverage of both innate and adaptive immunity, and will span the full spectrum of basic mechanisms to applied research. The meeting will be divided into nine half-day sessions, with approximately 36 invited internationally recognized speakers. Additional slots will be allotted for short oral presentations selected from submitted abstracts. There will also be poster sessions and many opportunities for informal interactions among participants throughout the week. Past GRCs in this series have been a great success and the 2012 meeting is likely to be oversubscribed. Early application is highly recommended.

Conference Program

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmINNATE MECHANISMS OF SELF/NON-SELF DISCRIMINATION
Discussion Leader: Caetano Reis e Sousa (London Research Institute, UK)
7:40 pm - 8:00 pm Veit Hornung (University of Bonn, Germany)
"Intracellular DNA sensing pathways"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:30 pm Jayne Danska (The Hospital for Sick Children, Canada)
"Sex-dependent alterations in the microbiome and metabolome protect NOD mice from autoimmunity"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:00 pm Maya Saleh (McGill University, Canada)
"Novel functions of the inflammasome in host resistance"
9:00 pm - 9:05 pm Discussion
9:05 pm - 9:25 pm Caetano Reis e Sousa (London Research Institute, UK)
"C-type lectin receptors in innate and adaptive immunity"
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmREGULATION AND FUNCTION OF INNATE LYMPHOID CELLS
Discussion Leader: Adrian Hayday (London Research Institute, UK)
9:00 am - 9:20 am Adrian Hayday (London Research Institute, UK)
"Lymphoid Stress-surveillance: how to regulate useful autoreactivity"
9:20 am - 9:30 am Discussion
9:30 am - 9:40 am Short Talk: Olivier Lantz (Institut Curie, France)
"MAIT cells: development, function and modifications in diseases"
9:40 am - 9:45 am Discussion
9:45 am - 9:55 am Short Talk: Nike Krautler (Garvan Institute of Medical Research, Australia)
"A perivascular origin of follicular dendritic cells"
9:55 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Yueh-hsiu Chien (Stanford University School of Medicine, USA)
"Gamma delta T cells, an innate source of IL-17?"
10:50 am - 11:00 am Discussion
11:00 am - 11:10 am Short Talk: Tomasz Zal (The University of Texas, USA)
"Visualizing the in vivo physiological autoreactivity by gammadelta TCR"
11:10 am - 11:15 am Discussion
11:15 am - 11:35 am Mitch Kronenberg (La Jolla Institute for Allergy & Immunology, USA)
"HVEM: A TNF family receptor critical for regulating mucosal immunity and inflammation"
11:35 am - 11:45 am Discussion
11:45 am - 12:05 pm Marco Colonna (Washington University in St Louis, USA)
"Innate lymphoid cells in mucosal immunity"
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Short Talk: Richard Ferrero (Monash Institute of Medical Research, Australia)
"NOD1-dependent sensing of bacterial outer membrane vesicles in epithelial cells; Its role in the development of adaptive immune responses"
12:25 pm - 12:30 pm Discussion
12:30 pmGroup Photo / Lunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session #1
5:30 pm - 7:30 pmMOLECULAR MECHANISMS OF LEUKOCYTE DEVELOPMENT
Discussion Leader: Barbara Kee (The University of Chicago, USA)
5:30 pm - 5:50 pm Boris Reizis (Columbia University, USA)
"Regulation of dendritic cell development and homeostasis"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Barbara Kee (The University of Chicago, USA)
"E proteins in lymphocyte lineage decisions"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Jane Skok (NYU Langone Medical Center, USA)
"The role of nuclear architecture in regulating recombination in developing lymphocytes"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pm Barbara Schraml (London Research Institute, UK)
"Lineage tracing of dendritic cells"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLEUKOCYTE TRAFFICKING AND CELL-CELL INTERACTIONS IN LYMPHOID TISSUES
Discussion Leader: Jason Cyster (University of California, San Francisco)
9:00 am - 9:20 am Philippe Bousso (Institut Pasteur, France)
"Dynamics of T cell activation and function in vivo"
9:20 am - 9:30 am Discussion
9:30 am - 9:40 am Short Talk: Tatyana Chtanova (Garvan Institute of Medical Research, Australia)
"In vivo two-photon photoconversion for long-term 'discontinuous' lymphocyte tracking"
9:40 am - 9:45 am Discussion
9:45 am - 9:55 am Short Talk: Irina Gurevich (Weizmann Institute of Science, Israel)
"Live cell imaging in vivo and in vitro reveals the importance of antigen transfer within DC networks for T cell activation"
9:55 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Michael Sixt (Institute of Science and Technology, Austria)
"Chemotactic guidance of leukocytes in vivo"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Sanjiv Luther (University of Lausanne, Switzerland)
"Fibroblasts of lymph nodes and their role in adaptive immunity"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Short Talk: Yina Huang (Washington University, USA)
"Phosphorylation of L-plastin by Mst1 regulates T cell polarization and migration"
11:40 am - 11:45 am Discussion
11:45 am - 12:05 pm Jason Cyster (University of California, San Francisco)
"Sphingolipids and oxysterols in B cell immunity"
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Short Talk: Frank Staal (Leiden University, Netherlands)
"Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session #2
5:30 pm - 7:30 pmANTIGEN PRESENTATION AND LYMPHOCYTE ACTIVATION
Discussion Leader: Mark Davis (Stanford University School of Medicine, USA)
5:30 pm - 5:50 pm Rose Zamoyska (University of Edinburgh, Scotland)
"How do signals that regulate T cells go wrong in autoimmunity"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Takeshi Saito (Riken RCAI, Japan)
"Spatiotemporal regulation of T cell activation and co-stimulation"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Facundo Batista (London Research Institute, UK)
"Early events in adaptive immunoresponse: from single molecule to in vivo"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pm Mark Davis (Stanford University School of Medicine, USA)
"T cell recognition and the nature of the alpha beta T cell repertoire"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLYMPHOCYTE HOMEOSTASIS & EFFECTOR CELL DIFFERENTIATION
Discussion Leader: Dan Littman (New York University School of Medicine, USA)
9:00 am - 9:20 am David Tarlinton (The Walter and Eliza Hall Institute of Medical Research, Australia)
"Integrating survival with differentiation during plasma cell development"
9:20 am - 9:30 am Discussion
9:30 am - 9:40 am Short Talk: Frann Antignano (University of British Columbia, Canada)
"G9a promotes T cell dependent colitis by restraining Th17 and Treg development"
9:40 am - 9:45 am Discussion
9:45 am - 9:55 am Short Talk: Scheherazade Sadegh-Nasseri (Johns Hopkins University, USA)
"Understanding how HLA-DO works"
9:55 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Pam Fink (University of Washington, USA)
"Post-thymic T cell Maturation"
10:50 am - 11:00 am Discussion
11:00 am - 11:10 am Short Talk: Nilabh Shastri (University of California, Berkeley)
"Non-classical MHC class Ib-restricted cytotoxic T cells monitor antigen processing in the ER"
11:10 am - 11:15 am Discussion
11:15 am - 11:25 am Short Talk: Carolyn King (University Hospital Basel, Switzerland)
"Induction of tissue pathology driven by asymmetric T cell division"
11:25 am - 11:30 am Discussion
11:30 am - 11:50 am E. John Wherry (University of Pennsylvania, USA)
"Regulating T cell responses during chronic infections"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pm Dan Littman (New York University School of Medicine, USA)
"Microbiota and role of lymphoid cells in inflammatory disease"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session #3
5:30 pm - 7:30 pmIMMUNE REGULATION AND AUTOIMMUNITY
Discussion Leader: Anne O'Garra (MRC National Institute for Medical Research, UK)
5:30 pm - 5:50 pm Gitta Stockinger (MRC National Institute for Medical Research, UK)
"Regulation of innate and adaptive IL-17 responses"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Fiona Powrie (University of Oxford, UK)
"Intestinal homeostasis and its breakdown in inflammatory bowel disease"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Anne O'Garra (MRC National Institute for Medical Research, UK)
"Regulation of the immune response in tuberculosis: mouse models to human disease"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pm Gabriel Loeb (Memorial Sloan-Kettering Cancer Center, USA)
"Molecular and cellular mechanisms of differentiation and function of regulatory T cells"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pmIMMUNITY TO INFECTION
Discussion Leader: Mike Bevan (University of Washington, USA)
9:00 am - 9:20 am Susan Kaech (Yale University, USA)
"Memory T cell differentiation during viral infection"
9:20 am - 9:30 am Discussion
9:30 am - 9:40 am Short Talk: Anne Kasmar (Harvard Medical School, USA)
"CD1a tetramers detect human lipopeptide-specific T cells"
9:40 am - 9:45 am Discussion
9:45 am - 9:55 am Short Talk: Mainthan Palendira (Garvan Institute of Medical Research, Australia)
"Expansion of somatically reverted memory CD8+ T cells in XLP disease due to selective pressure from EBV"
9:55 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Marc Jenkins (University of Minnesota, USA)
"Origins of CD4+ memory T cells"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Mike Bevan (University of Washington, USA)
"Controlling CD8 responses in the presence and absence of inflammation"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Short Talk: Safia Deddouche (Cancer Research UK)
"Identification of MDA5/LGP2 agonists in cells infected with picornavirus"
11:40 am - 11:45 am Discussion
11:45 am - 12:05 pm Antonio Lanzavecchia (Institute for Research in Biomedicine, Switzerland)
"Human immune response to pathogens"
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Short Talk: Sarah Enouz (Swiss Vaccine Research Institute, Switzerland)
"A strong difference in the affinity threshold for peripheral T cell activation and negative selection underpins autoimmunity"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 5:30 pmFree Time
5:30 pm - 7:30 pmHOST-MICROBIOME INTERACTIONS IN GUT HOMEOSTASIS & PATHOLOGY
Discussion Leader: Yasmine Belkaid (NIAID, USA)
5:30 pm - 5:50 pm Yasmine Belkaid (NIAID, USA)
"Innate and adaptive immunity to commensals during acute infection"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Gerard Eberl (Institut Pasteur, France)
"Development of regulation of innate lymphoid cells"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm David Artis (University of Pennsylvania, USA)
"Immune regulation at barrier surfaces"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pm Sarkis Mazmanian (Caltech, USA)
"Learning to tolerate our microbial self"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

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