Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Initiation and Modulation of the Immune Response
Discussion Leader: Federica Sallusto (Institute for Research in Biomedicine, Università della Svizzera Italiana, Switzerland)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:10 pm
Ruslan Medzhitov (Yale School of Medicine, USA)
"Immune System and Tissue Homeostasis"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Ronald Germain (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Imaging the Immune System to Reveal Its Functional Organization and Principles of Operation"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Michel Nussenzweig (The Rockefeller University, USA)
"Germinal Centers in Humoral Immunity"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Gene Programming of Immune Cells
Discussion Leader: Donna Farber (Columbia University Medical Center, USA)
9:00 am - 9:20 am
Ido Amit (Weizmann Institute of Science, Israel)
"The Power of ONE: Immunology in the Age of Single Cell Genomics"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Roger Geiger (Institute for Research in Biomedicine, Università della Svizzera Italiana, Switzerland)
"Multiple Mechanisms of T Cell Preparedness for Rapid Activation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Selected from Poster Abstracts: Ayaka Sugiura (Vanderbilt University School of Medicine, USA)
"xCT and Cystine Uptake Regulates Th17 and Treg Cells"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Alexander Rudensky (Memorial Sloan Kettering Cancer Center / HHMI Investigator, USA)
"Novel Insights into Regulatory T Cell Differentiation and Function"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Vijay Kuchroo (Harvard Medical School / Brigham and Women's Hospital, USA)
"Regulatory Networks in the Differentiation of Effector and Regulatory T Cells"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Joel Wilmore (University of Pennsylvania, USA)
"IgA Plasma Cells Express Unique Transcriptional Programs in the Gut and Bone Marrow"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Laura Donlin (Hospital for Special Surgery, Weill Cornell Medicine, USA)
"Macrophage Diversity and Function in Human Tissue Affected by Autoimmunity"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Development, Function and Regulation of Innate Lymphoid Cells
Discussion Leader: Annette Oxenius (Institute of Microbiology, ETH Zurich, Switzerland)
7:30 pm - 7:50 pm
Henrique Veiga-Fernandes (Fundação Champalimaud, Portugal)
"Innate Lymphoid Cells and the Second Brain"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
James Di Santo (Institut Pasteur / Inserm, France)
"How the Innate Adapts: Generating Diverse Human Innate Lymphoid Cells 'On Demand'"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Albert Bendelac (University of Chicago, USA)
"Development and Specificity of Homeostatic Intestinal IgA"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Nadia Martinez-Martin (Genentech, USA)
"Towards the Human Co-Receptome: A Systematic Exploration of the Immunoglobulin Superfamily Interactome"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Immune Repertoires
Discussion Leader: Laura Mackay (Peter Doherty Institute for Infection and Immunity, University of Melbourne, Australia)
9:00 am - 9:20 am
Marc Jenkins (University of Minnesota, USA)
"Heterogeneity in the Pre-Immune CD4+ T Cell Repertoire"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Donna Farber (Columbia University Medical Center, USA)
"Tissue Determinants of T Cell Differentiation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Selected from Poster Abstracts: Hiroyuki Takaba (The University of Tokyo, Japan)
"Epigenetic Regulation of Self-Antigen Expression in the Thymus"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Bana Jabri (University of Chicago, USA)
"Chronic Inflammation Permanently Reshapes the Tissue-Resident γδ Compartment"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Mark Davis (Stanford University School of Medicine, USA)
"Tools for T Cells: Decoding the T Cell Response Repertoire in Cancer, Autoimmunity and Infectious Diseases"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Pradyot Dash (St. Jude Children's Research Hospital, USA)
"Quantifiable Predictive Features of Epitope-Specific Repertoire: Understanding TCR Repertoire Structure, Specificity and Plasticity"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Giorgio Napolitani (MRC Human Immunology Unit, University of Oxford, United Kingdom)
"Clonal Analysis of Salmonella-Specific Effector T Cells Reveals Serovar Specific and Cross-Reactive T Cell Responses"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell-Cell Communications in Immunity
Discussion Leader: Facundo Batista (Ragon Institute of MGH, MIT and Harvard, USA)
7:30 pm - 7:50 pm
Morgan Huse (Memorial Sloan-Kettering Cancer Center, USA)
"Mechanical Control of Cytotoxic T Cell Function"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Carola Vinuesa (The Australian National University, Australia)
"Understanding T:B Synapses in Human Germinal Centers"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Shannon Turley (Genentech, USA)
"Stromal Activation in Cancer Immunology and Immunotherapy"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Venizelos Papayannopoulos (Francis Crick Institute, United Kingdom)
"Neutrophil Extracellular Traps in Immunity and Disease"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immune Regulation and Inflammation
Discussion Leader: Alexander Rudensky (Memorial Sloan Kettering Cancer Center / HHMI Investigator, USA)
9:00 am - 9:20 am
Sarah Teichmann (Wellcome Sanger Institute, United Kingdom)
"Immunogenomics One Cell at a Time"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Peter Savage (University of Chicago, USA)
"Regulatory T Cell Choreography Directed by Endogenous Self-Ligands"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Selected from Poster Abstracts: Francesco Marangoni (Massachusetts General Hospital, USA)
"Intravital Imaging of NFAT Signaling Reveals that Short-Lived Activation of Tumor-Associated T Regulatory Cells Instructs Cancer Immune Escape"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Marcia Haigis (Harvard Medical School, USA)
"Mitochondrial Biology in T Cells"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Adrian Liston (Vlaams Instituut voor Biotechnologie (VIB), Belgium)
"Using Machine Learning and Systems Immunology to Predict Immune Diseases"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Toshinori Nakayama (Graduate School of Medicine, Chiba University, Japan)
"Pathogenic Th2 (Tpath2) Cells in Airway Inflammation: Fibrosis Inducing Tpath2 Cells"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Kaitlyn Sadtler (Massachusetts Institute of Technology, USA)
"Applications of Immunoengineering in Tissue Engineering and Regenerative Medicine"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Microbial Interactions at Barrier Surfaces
Discussion Leader: Carola Vinuesa (The Australian National University, Australia)
7:30 pm - 7:50 pm
Caetano Reis e Sousa (The Francis Crick Institute, United Kingdom)
"Dendritic Cells in Immune Regulation and Inflammation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Kathy McCoy (University of Calgary, Canada)
"Microbial Regulation of Innate Immunity at Mucosal and Systemic Sites"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Dan Littman (New York University School of Medicine, USA)
"Microbiota-Immune Cell Interplay in Local and Systemic Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Laura Mackay (Peter Doherty Institute for Infection and Immunity, University of Melbourne, Australia)
"Heterogeneity of Tissue-Resident Memory T Cells"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immunity to Infections
Discussion Leader: Bali Pulendran (Stanford University, USA)
9:00 am - 9:20 am
Matteo Iannacone (San Raffaele Scientific Institute, Italy)
"Imaging T Cell Responses in the Liver"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Annette Oxenius (Institute of Microbiology, ETH Zurich, Switzerland)
"T Cell Immunity in Acute and Chronic Viral Infection"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Selected from Poster Abstracts: Lalit Dubey (University of Lausanne, Switzerland)
"IL-4Ra Expressing B Cells Govern CXCL13 Production by Fibroblastic Reticular Cells"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Antonio Lanzavecchia (Institute for Research in Biomedicine, Università della Svizzera Italiana, Switzerland)
"Lessons from the Analysis of the Immune Response to Plasmodium falciparum "
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Anne Puel (INSERM, France)
"Novel Inborn Errors of Immunity and Syndromic Chronic Mucocutaneous Candidiasis"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Melissa Chng (Singapore Immunology Network, Singapore)
"Highly Multiplexed Epitope Tetramer Screening and Deep Phenotyping of T Cells over the Course of Natural Dengue Infection Using Mass Cytometry"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Bernd Lepenies (University of Veterinary Medicine Hannover, Germany)
"The C-Type Lectin Receptor CLEC12A Recognizes Plasmodial Hemozoin and Contributes to Cerebral Malaria Development"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Antibodies, Vaccines and Immunotherapies
Discussion Leader: Matteo Iannacone (San Raffaele Scientific Institute, Italy)
7:30 pm - 7:50 pm
Klaus Frueh (Oregon Health & Science University, USA)
"New Vaccine Strategies Using Cytomegalovirus"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Bali Pulendran (Stanford University, USA)
"From Data to Understanding Through Systems Vaccinology"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Selected from Poster Abstracts: Rajat Varma (Xencor Inc., USA)
"Potency-Reduced IL15/IL15Ra Heterodimeric Fc-Fusions Display Enhanced In Vivo Activity Through Increased Exposure"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Selected from Poster Abstracts: Rodolfo Vicetti Miguel (Stanford University School of Medicine, USA)
"Chlamydia-Activated B Cells as Cancer Immunotherapy"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Selected from Poster Abstracts: Michael Birnbaum (Massachusetts Institute of Technology, USA)
"Decoding Immune Recognition"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure