Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Immune Responses
Discussion Leader: Alexander Rudensky (Memorial Sloan Kettering Cancer Center, United States)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:15 pm
Diane Mathis (Harvard Medical School, United States)
"A Previously Jettisoned View of T Cell Tolerance Induction"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
Jason Cyster (University of California, San Francisco, United States)
"Guidance Cues for Innate Immune Cells"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:25 pm
Gillian Griffiths (University of Cambridge, United Kingdom)
"Marathons for T Cells: How They Keep Going"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immune Cells Trafficking and Activation
Discussion Leaders: Jason Cyster (University of California, San Francisco, United States) and Matteo Iannacone (San Raffaele Scientific Institute, Italy)
9:00 am - 9:20 am
Ronald Germain (National Institute of Allergy and Infectious Diseases, NIH, United States)
"New Imaging Approaches for Probing Immune System Organization and Activity in a Tissue Context"
9:20 am - 9:25 am
Discussion
9:25 am - 9:40 am
Samuel Kazer (Boston Children's Hospital, United States)
"Learning Dynamic Ensemble Host-Virus Interactions in the Nasal Mucosa at Single-Cell Resolution"
9:40 am - 9:45 am
Discussion
9:45 am - 10:00 am
Peter Krueger (Vir Biotechnology / University of Minnesota, United States)
"Foreign Epitope-Specific Regulatory T Cells Limit Terminal Differentiation of T Helper-1 Cells During Influenza Infection"
10:00 am - 10:05 am
Discussion
10:05 am - 10:25 am
Michael Sixt (Institute of Science and Technology Austria, Austria)
"Orchestration of Leukocyte Migration by Self-Organised Chemokine Gradients"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Maureen McGargill (St. Jude Children's Research Hospital, United States)
"Induction of Broadly Reactive Influenza Antibodies Increases Susceptibility to Autoimmunity"
11:20 am - 11:25 am
Discussion
11:25 am - 11:40 am
Milas Ugur (University of Würzburg, Germany)
"cDC1 and CDC2 Generation in the Lymph Nodes"
11:40 am - 11:45 am
Discussion
11:45 am - 12:00 pm
Joris van der Veeken (Research Institute of Molecular Pathology, Austria)
"Foxp3 Dependent and Independent Functions of Peripherally Induced Regulatory T Cells"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Gabriel Victora (The Rockefeller University, United States)
"Clonal and Cellular Dynamics of the Germinal Center Response"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Carla Rothlin (Yale University, United States) and Carola Vinuesa (The Francis Crick Institute, United Kingdom)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Gene Programming of Immune Cells
Discussion Leaders: Diane Mathis (Harvard Medical School, United States) and Gabriel Victora (The Rockefeller University, United States)
6:00 pm - 6:20 pm
Thomas Boehm (Max Planck Institute of Immunobiology and Epigenetics, Germany)
"Evolutionary Innovations in Vertebrate Immunity"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
Laura Mackay (University of Melbourne, Australia)
"Programming Tissue-Resident Memory T Cell Responses"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Bongiwe Ndlovu (University of KwaZulu-Natal, South Africa)
"Neutralization of HIV-1 Subtype C Transmitted/Founder Viruses by Broadly Neutralizing Monoclonal Antibodies in Adults and Infants"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
Nir Yosef (University of California, Berkeley, United States)
"Single Cell Analysis of Thymocyte Development Through Joint Modeling of RNA and Proteins"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:55 pm
Gioacchino Natoli (European Institute of Oncology (IEO), Italy)
"Control of Macrophage Activation by Clinical Kinase Inhibitors"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Immunoregulation
Discussion Leaders: Laura Mackay (University of Melbourne, Australia) and Gioacchino Natoli (European Institute of Oncology (IEO), Italy)
9:00 am - 9:20 am
Burkhard Becher (University of Zurich, Switzerland)
"The T Cell Phagocyte Interface During Inflammation"
9:20 am - 9:25 am
Discussion
9:25 am - 9:40 am
Sophie Giguere (Ragon Institute of MGH, MIT, and Harvard, United States)
"Naturally Antibody-Secreting Cells Enrich for Inosine in tRNAs, Matching the Codon Demand of Immunoglobulin Constant Regions"
9:40 am - 9:45 am
Discussion
9:45 am - 10:00 am
William Dunker (University of Washington, United States)
"Defining How the Proto-Oncogene cSrc Regulates cGAS DNA Sensing in Cancer"
10:00 am - 10:05 am
Discussion
10:05 am - 10:25 am
Bruno Silva-Santos (Instituto de Medicina Molecular, U. Lisbon, Portugal)
"Molecular Programming of Gamma-Delta T Cell Subsets and Their Immunoregulatory Functions"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Michael Birnbaum (Massachusetts Institute of Technology, United States)
"New Approaches to Decode Immune Recognition"
11:20 am - 11:25 am
Discussion
11:25 am - 11:40 am
Murad Mamedov (University of California, San Francisco / Gladstone Institutes, United States)
"CRISPR Screens Reveal AMPK-Dependent Metabolic Regulation of Cancer Cell Interactions with gamma-delta T cells T Cells"
11:40 am - 11:45 am
Discussion
11:45 am - 12:00 pm
Sophia Liu (Harvard University, United States)
"Spatially Mapping T Cell Receptors and Transcriptomes"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Christophe Benoist (Harvard Medical School, United States)
"Regulating T Regulatory Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Immune Responses to Vaccine and Infection
Discussion Leaders: Carola Vinuesa (The Francis Crick Institute, United Kingdom) and Bruno Silva-Santos (Instituto de Medicina Molecular, U. Lisbon, Portugal)
6:00 pm - 6:20 pm
Matteo Iannacone (San Raffaele Scientific Institute, Italy)
"Immune Surveillance of the Liver"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:40 pm
Azza Idris (Vaccine Research Center, NIAID/NIH, United States)
"Monoclonal Antibodies for Malaria Prevention"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Federica Sallusto (Institute for Research in Biomedicine - Università della Svizzera italiana, Switzerland)
"Microbe-induced T Cell Differentiation in Humans"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
Michael Dustin (Kennedy Institute of Rheumatology, University of Oxford, United Kingdom)
"Supramolecular Effector Mechanisms Employed by Helper and Cytotoxic T Cells"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:55 pm
Antonio Lanzavecchia (INGM, Italy)
"Structure, Stability and Dynamics of Memory B Cells and Circulating Plasma Cells"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immunity at Mucosal Sites
Discussion Leaders: Federica Sallusto (Institute for Research in Biomedicine - Università della Svizzera italiana, Switzerland) and Alison Ringel (MIT/Ragon Institute, United States)
9:00 am - 9:20 am
Douglas Kwon (The Ragon Institute of MGH, MIT and Harvard, United States)
"Impact of Host-Microbial Interactions in the Female Genital Tract on Reproductive Health"
9:20 am - 9:25 am
Discussion
9:25 am - 9:40 am
Julia Berkson (FDA, United States)
"Immune Responses to Bacteriophage Therapy Targeting Vancomycin-Resistant Enterococcus Colonization"
9:40 am - 9:45 am
Discussion
9:45 am - 10:00 am
Clarissa Campbell (CeMM, Austria)
"Microbial Bile Acid Metabolism Shapes Effector T Cell Responses During Inflammation"
10:00 am - 10:05 am
Discussion
10:05 am - 10:25 am
Jose Ordovas-Montanes (Boston Children's Hospital, United States)
"Single-Cell Biology of Barrier Tissues and COVID-19"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Dan Littman (New York University School of Medicine, United States)
"Programming of Gut Microbiota-Specific T Cells"
11:20 am - 11:25 am
Discussion
11:25 am - 11:40 am
Nicola Diny (Francis Crick Institute, United Kingdom)
"The Aryl Hydrocarbon Receptor Promotes Tissue Adaptation of Eosinophils in Mice"
11:40 am - 11:45 am
Discussion
11:45 am - 12:00 pm
Lijun Sun (Beth Israel Deaconess Medical Center, Harvard Medical School, United States)
"Selective AHR Immune Modulators Prevents Development of Murine Colitis by Upregulating IL-22"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Christina Zielinski (Leibniz Institute for Natural Product Research and Infection Biology, Germany)
"T Cells with Holes"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Sensors, Microbes and Inflammation
Discussion Leader: Antonio Lanzavecchia (INGM, Italy)
6:00 pm - 6:20 pm
Carla Rothlin (Yale University, United States)
"Principles of Resolving and Non-Resolving Inflammation"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
Hernandez Moura Silva (Massachusetts institute of Technology/ The Ragon Institute of MGH, MIT & HARVARD, United States)
"The Contribution of Perivascular Macrophages to the Regulation of Organ Physiology"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Kondwani Jambo (Malawi-Liverpool-Wellcome Programme (MLW) and Liverpool School of Tropical Medicine (LSTM), Malawi)
"Differential Localization and Functional Heterogeneity of Mucosal CD8+ T Cells"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
Charles Evavold (Ragon Institute of MGH, MIT, and Harvard, United States)
"Metabolic Control of Inflammatory Cell Death"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:55 pm
Chrysothemis Brown (Memorial Sloan Kettering Cancer Center, United States)
"Development Windows for Immune Tolerance"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Integrative Immunology
Discussion Leaders: Dan Littman (New York University School of Medicine, United States) and Carla Rothlin (Yale University, United States)
9:00 am - 9:20 am
Ana Domingos (University of Oxford, United Kingdom)
"Neuroimmunometabolism"
9:20 am - 9:25 am
Discussion
9:25 am - 9:40 am
Anthonie Zwijnenburg (Karolinska Institutet & Karolinska University Hospital, Sweden)
"CX3CR1 is a Graded and Universal Differentiation Marker Unifying Human and Murine T Cell Differentiation"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Asya Rolls (Technion - Israel Institute of Technology, Israel)
"Remembering Immunity: Neuronal Representation and Regulation of Immune Reactions"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Carola Vinuesa (The Francis Crick Institute, United Kingdom)
"TLR7 Gain-of-Function in Human Systemic Autoimmunity"
11:00 am - 11:05 am
Discussion
11:05 am - 11:20 am
Asheley Chapman (Massachusetts Institute of Technology, United States)
"Targeted Deletion of Non-neutralizing B cells to Enhance the Germinal Center Response: A Chemo-conjugate Approach to HIV Vaccination"
11:20 am - 11:25 am
Discussion
11:25 am - 11:40 am
Joel Rurik (Perelman School of Medicine at the University of Pennsylvania, United States)
"CAR T Cells Produced In Vivo to Treat Cardiac Injury"
11:40 am - 11:45 am
Discussion
11:45 am - 12:00 pm
Sofía C. Khouili (Centro Nacional de Investigaciones Cardiovasculares- CNIC, Spain)
"Blockade of Mitochondrial Fission Sustains mTORC1 Activation and Promotes Tissue-Resident Memory CD8+ T Cell Generation"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Miguel Soares (Fundacao Calouste Gulbenkian, Instituto Gulbenkian de Ciencia, Portugal)
"Metabolic Reprogramming as a Defense Strategy Against Infection"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Tumor Immunity
Discussion Leaders: Asya Rolls (Technion - Israel Institute of Technology, Israel) and Ana Domingos (University of Oxford, United Kingdom)
6:00 pm - 6:20 pm
Morgan Huse (Memorial Sloan Kettering Cancer Center, United States)
"Mechanical Regulation of Immunosurveillance"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Alison Ringel (MIT/Ragon Institute, United States)
"Dietary Factors that Shape Immunity in Tumors"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Leyuan Ma (University of Pennsylvania/Children's Hospital of Philadelphia, United States)
"A Synthetic Vaccine Bridges CAR T Cells and Endogenous T Cells to Target Tumors with Pre-Existing Antigenic Heterogeneity"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Jamie Spangler (Johns Hopkins University, United States)
"Engineered Multispecific Down-regulating Antibodies for Cancer Immunotherapy"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
