SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:45 pm | Welcome / Introductory Comments by GRC Site Staff |
7:45 pm - 9:30 pm | Fungal PAMPS |
| Discussion Leader: Carl Figdor (Nijmegen Centre for Molecular Life Sciences) |
7:45 pm - 8:10 pm | Frans Klis (University of Amsterdam)
"Lessons to be learned from the wall proteome and secretome of C. albicans for infection detection and vaccine development" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Neil Gow (University of Aberdeen)
"Fungal cell walls and the activation of the innate immune response" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | William Goldman (University of North Carolina)
"Molecular mimicry and crypsis in Histoplasma pathogenesis" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Innate Fungal Recognition |
| Discussion Leader: Daniel Poulain (Université Lille) |
9:00 am - 9:25 am | Mihai Netea (Radboud University)
"Innate immune discrimination of Candida colonization vs. invasion" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Joseph El Khoury (Massachusetts General Hospital)
"Scavenger receptors and Fungal pathogenesis" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:35 am | Coffee Break |
10:35 am - 11:00 am | Jurgen Ruland (Technischen Universität München)
"ITAM Receptor Signaling in Innate Antifungal Immunity" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Carl Figdor (Nijmegen Centre for Molecular Life Sciences)
"C-type lectins in fungal recognition" |
11:35 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Lars Erwig (University of Aberdeen)
"Video microscopy and sophisticated image analysis reveal novel insights into the phagocytosis of C. albicans" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Duccio Cavalieri (University of Firenze)
"A Systems Biology approach to dissect early transcriptional events regulating immune discrimination of fungi" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Jay Vyas (Massachusetts General Hospital)
"TLR9 is recruited to Aspergillus fumigatus phagosomes" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Adaptive Immunity and Immune Regulation |
| Discussion Leader: Bruce Klein (University of Wisconsin-Madison) |
7:30 pm - 7:55 pm | Caetano Reis e Sousa (Cancer Research UK)
"Dendritic cells in the response to fungal infection" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Arturo Casadevall (Albert Einstein College of Medicine)
"New basic immunological insights into antibody function from studies with Cryptococcus neoformans" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Anna Vecchiarelli (University of Perugia)
"C. neoformans capsular polysaccharide and T cell damage" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Teunis Geijtenbeek (University of Amsterdam)
"Dectin-1 signaling links extracellular fungal recognition to inflammasome-independent IL-1beta processing" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Organ-Specific Immunity |
| Discussion Leader: Francoise Dromer (Institute Pasteur) |
9:00 am - 9:25 am | Sarah Gaffen (University of Pittsburgh)
"Th17 cells and IL-17 receptor signaling in oral candidiasis" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Paul Fidel (Louisiana State University)
"New paradigms for host responses associated with vaginal candidiasis: the role of innate immunity" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:35 am | Coffee Break |
10:35 am - 11:00 am | Bernhard Hube (Hans Knoell Institute)
"Interactions of Candida albicans with oral epithelial cells" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Scott Filler (David Geffen School of Medicine at UCLA)
"Mechanisms of C. albicans trafficking to the brain" |
11:35 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Dan Kaplan (University of Minnesota)
"Langerhans cells and Langerin+ dermal dendritic cells reciprocally regulate the generation of Candida albicans specific Th17 and Th1 cells" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Eric Pearlman (Case Western Reserve University)
"The role of innate and adaptive immunity in Aspergillus and Fusarium infections of the cornea" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Tobias Hohl (Fred Hutchinson Cancer Research Center)
"Monocyte-dependent antifungal defense in the lung" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Fungal Diseases and Immunodeficiency |
| Discussion Leader: David Denning (The University of Manchester) |
7:30 pm - 7:55 pm | Kieren Marr (Johns Hopkins Medical School)
"Prevention of fungal infections after transplant: Translating immunologic risks into treatment strategies" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Brahm Segal (Roswell Park Cancer Institute)
"NADPH oxidase: a master regulator of antifungal host defense and inflammation" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Jay Kolls (LSU Health Sciences Center)
"Regulation of CD4+ T-cell responses to fungi" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Teresa Zelante (Università degli Studi di Perugia)
"IL-22 provides antifungal resistance at mucosal surfaces" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Immunity to Specific Pathogens |
| Discussion Leader: Anna Vecchiarelli (University of Perugia) |
9:00 am - 9:25 am | Vera Calich (Instituto de Diencias Biomedicas)
"Treg cells in paracoccidioidomycosis: friend or foe?" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Frank Ebel (Ludwig-Maximilians-University)
"Interactions of Aspergillus fumigatus with human innate immune cells" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:35 am | Coffee Break |
10:35 am - 11:00 am | Chad Steele (University of Alabama at Birmingham)
"Macrophage activation during Pneumocystis lung infection" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Bruce Klein
"Regulation of vaccine immunity to dimorphic fungi" |
11:35 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Joshua Fierer (University of California, San Diego)
"Pattern recognition receptors and innate immunity to coccidioidomycosis" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Louis de Repentigny (Université de Montréal)
"Differential susceptibility to cryptococcosis in mice expressing the HIV-1 transgene" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Amariliz Rivera (UMDNJ-New Jersey Medical School)
"Innate immune receptors and the differentiation of Aspergillus fumigatus-specific CD4 T cells" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Immunotherapy and Vaccination |
| Discussion Leader: Scott Filler (Harbor-UCLA Medical Center) |
7:30 pm - 7:55 pm | Marcel Wuethrich (University of Wisconsin)
"Vaccination against the North American Systemic Mycoses requires Th17 cells" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Antonio Cassone (Istituto Superiore di Sanita)
"Vaccination against opportunistic fungal infections with emphasis on universal vaccines" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | David Denning (National Aspergillosis Centre Manchester)
"Clinical study of an Aspergillus vaccine - who and how" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Haibin Huang (University of Massachusetts)
"Relative contributions of Dectin-1 and complement to immune responses to beta-glucan particles" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Fungal Diseases as a Consequence of Immunomodulation |
| Discussion Leader: Bart Jan Kullberg (Radboud University) |
9:00 am - 9:25 am | Jean-Paul Latge (Institute Pasteur)
"Extracellular vs skeletal cell wall polysaccharides of Aspergillus fumigatus: To be or not to be immunogenic..." |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | George Deepe (University of Cincinnati College of Medicine)
"Cytokine-Chemokine Networks in Histoplasmosis" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:35 am | Coffee Break |
10:35 am - 11:00 am | Kazuyoshi Kawakami (Tohoku University Graduate School of Medicine)
"Host defense strategies targeting polysaccharides and glycolipids against Cryptococcus neoformans" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Flavia De Bernardis (Istituto Superiore di Sanità)
"Positive and negative immunomodulation in vaginal candidiasis" |
11:35 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Agostinho Carvalho (University of Perugia)
"Cracking the genetic code for susceptibility to aspergillosis in allogeneic stem cell transplantation" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Kirsten Nielsen (Univeristy of Minnesota)
"Interaction between cryptococcal titan cells and the innate immune system affects pathogenesis" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Floyd Wormley (The University of Texas at San Antonio)
"Induction of Protective Immunity against Pulmonary Cryptococcosis" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | From Bench to Bedside and Back Again |
| Discussion Leader: Jay Kolls (Louisiana State University) |
7:30 pm - 7:55 pm | Liise-anne Pirofski (Albert Einstein College of Medicine)
"Antibody, B cells and immunity to Cryptococcus neoformans: new perspectives on an old question" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Tom Harrison (St George's University of London)
"Interferon-gamma therapy for cryptococcosis" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Bart-Jan Kullberg (Radboud University)
"Identifying patients at risk for candidiasis" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Mihalis Lionakis (National Institutes of Allergy & Infectious Diseases)
"Organ-specific Innate Immune Responses in a Mouse Model of Invasive Candidiasis" |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |