Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Immunity to Pulmonary Fungal Infections
7:40 pm - 7:45 pm
General Discussion
7:45 pm - 8:15 pm
"Regulation of Cell Shape and Virulence in Endemic Fungal Pathogens"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:00 pm
"Of Mice and Humans: Innate Defense Against Candidiasis"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Selected Abstract: Epithelial-Immune Cell Crosstalk Orchestrates Pulmonary Immunity to Aspergillus fumigatus "
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Myeloid Cell Dysfunction Drives Influenza-associated Pulmonary Aspergillosis (IAPA)"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Mycobacterial Co-infection Drives Hyperinflammatory Responses and Impaired Fungal Clearance of Aspergillus fumigatus via NOD2"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Adding Insult to Injury: Invasive Fungal Diseases Complicating Viral Infections"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Mechanisms of Host Cell Invasion During Mucormycosis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Lower Respiratory Tract Single Cell and Neutrophil Extracellular Trap Profiling of COVID-19-Associated Pulmonary Aspergillosis"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Influenza-Induced Destruction of Respiratory Epithelium and Myeloid Cytokine Hyperinflammatory Response Drive Influenza-Associated Pulmonary Aspergillosis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Early-Career Investigator Presentations
7:30 pm - 7:45 pm
"The Role of IL-6 Signaling in Sepsis-Induced Pulmonary Aspergillosis"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Fungal Adaptations to the Host Environment Dramatically Impact C. Albicans- immune Interactions"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Mycoviruses: The Backseat Drivers of Fungal Diseases"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Hijacking Bat Keratinocytes: Mechanistic Insights into the Early Stages of White-Nose Syndrome"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Vaccine-Induced Immune Responses to Pulmonary Coccidioidomycosis"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"IL-1: A Central Mediator in Mucosal Candida Disease"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Therapeutic Strategies: From Vaccines to Immunotherapies
9:00 am - 9:20 am
"Characterization of the Mannan Immune Epitope on the Cell Wall of Candida Albicans"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Advancing a Broadly Protective Vaccine Strategy for the Prevention of Fungal Infections"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"?cps1 : A Gene-Deletion Mutant of Coccidioides posadasii as a Preventative Vaccine Candidate for Dogs"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"Pulmonary Transcriptomics Reveal Immune Dysfunction and Exhaustion in Mice with Invasive Pulmonary Mucormycosis, Partially Restored by PD-L1 Immune Checkpoint Blockade"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Lung Epithelial Cells Regulate the Immune Response to Intranasal Vaccination Against Coccidioidomycosis"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"M-CSF Treatment Enhances Tissue Resident Alveolar Macrophage Function to Protect from Pulmonary Aspergillus fumigatus Infection"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Innate Cell Contributions to Vaccine-induced Antifungal Protection."
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Fungi in Oncologic and Immune-Mediated Diseases
7:30 pm - 7:50 pm
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Candida albicans -Specific Immune Recognition in Allergic Airway Disease and Cerebral Mycosis"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Development of Pathogenic CD4+ T Cell Responses against Fungi in Patients with Inflammatory Bowel Diseases"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Mycobiota-host Immune Interactions at High Resolution: New Implications for Inflammatory Diseases and Cancer"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Inhalation of Aspergillus Alkaline Protease 1 Inures Mice With Permanent Allergen-Specific Immunity and Exacerbated Allergic Lung Inflammation"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
From Bench to Bedside: Translating Fungal Immunity to Patients
9:00 am - 9:20 am
"Novel Therapeutics for Fungal Keratitis: Looking to the Corneal Environment for Insights"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Improved Therapeutics and Diagnostics for Pneumocystis Pneumonia"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Demystifying the NIH Grant Application Process and Current Funding Opportunities"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"Genetic IL-17A Variation and Mycobiome Dysbiosis Contribute to Liver Fibrosis in NAFLD Patients"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Human p11-Mediated Re-Direction of Phagosomes to the Recycling Endosome-Expulsion Pathway by a Fungal Pathogen"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Aspergillus Melanin Potently Blocks Human Airway Epithelium-Mediated Inflammation"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Cytotoxic Cells in the CNS of Subjects with Cryptococcal Meningitis and Advanced HIV"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Immunogenetics and Fungal Immunity
7:30 pm - 7:50 pm
"Functional Genomics Approaches for Fungal Sepsis: the Genetic Architecture of Susceptibility and Survival Among Fungal Sepsis Patients"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Genetic Determinants of Immunometabolic Responses to Fungal Infection"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Candida Albicans Pra 1 Zine Scavenger Drive VVC Immunopathology"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Defining Microglial Heterogeneity in the Fungal-Infected CNS"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Neutrophils Demonstrate Variation in Transcriptional and Epigenetic Signatures at Homeostasis, Presenting Avenues of Heterogeneity in Response to Candida "
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Innate Immunity in Fungal Infections
9:00 am - 9:20 am
"Differential Effects of Candida albicans-CEACAM Receptor Interaction on Host Response in the Context of Systemic Infection"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Subunit Cryptococcus Vaccines: Immune Correlates of Protection"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Neutrophil Evasion by Candida Auris "
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Decrypting the Monocyte Response to Cryptococcus "
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"New Insights into Candida-macrophage Interactions"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Effector Pathways in Fungal Immunity: Contributions of the Adaptive Immune Response
7:30 pm - 7:50 pm
"Development of a Human Subunit Vaccine Against Coccidioidomycosis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"T Cells with Holes – a New Way to Communicate Anti-fungal Host Defence"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Maladaptive T Cell Responses in Disseminated Coccidioidomycosis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"A Spatially Resolved Transcriptomic "Atlas" of Oropharyngeal Candidiasis Reveals a Th-2 and Th-17 Response, Similar to Allergic Inflammation"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"IL-17A-Producing ?d T Cells Are Critical For Cutaneous Immunity Against Malassezia and Are Directly Activated by Malassezia -Derived Compounds"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure