Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Immunity to Pulmonary Fungal Infections
Discussion Leaders: Amariliz Rivera (Rutgers New Jersey Medical School, United States) and Sarah Gaffen (University of Pittsburgh School of Medicine, Division of Rheumatology & Clinical Immunology, United States)
7:40 pm - 7:45 pm
General Discussion
7:45 pm - 8:15 pm
Anita Sil (University of California, San Francisco, United States)
"Regulation of Cell Shape and Virulence in Endemic Fungal Pathogens"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:00 pm
Michail Lionakis (National Institute of Allergy and Infectious Diseases, NIH, United States)
"Of Mice and Humans: Innate Defense Against Candidiasis"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Kathleen Mills (Weill Cornell Graduate School/Memorial Sloan Kettering Cancer Center, United States)
"Selected Abstract: Epithelial-Immune Cell Crosstalk Orchestrates Pulmonary Immunity to Aspergillus fumigatus "
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Fungi and Co-Infections
Discussion Leaders: Amy Hise (Case Western Reserve University, United States) and Gordon Brown (University of Exeter, United Kingdom)
9:00 am - 9:20 am
Joshua Obar (Geisel School of Medicine, Dartmouth College, United States)
"Myeloid Cell Dysfunction Drives Influenza-associated Pulmonary Aspergillosis (IAPA)"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Darius Armstrong-James (Imperial College London, United Kingdom)
"Mycobacterial Co-infection Drives Hyperinflammatory Responses and Impaired Fungal Clearance of Aspergillus fumigatus via NOD2"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Ilan Schwartz (Duke University, United States)
"Adding Insult to Injury: Invasive Fungal Diseases Complicating Viral Infections"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
ASHRAF IBRAHIM (The Lundquist Institute at Harbor-UCLA Medical Center, United States)
"Mechanisms of Host Cell Invasion During Mucormycosis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Simon Feys (KU Leuven, Belgium)
"Lower Respiratory Tract Single Cell and Neutrophil Extracellular Trap Profiling of COVID-19-Associated Pulmonary Aspergillosis"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Laura Seldeslachts (KULeuven, Belgium)
"Influenza-Induced Destruction of Respiratory Epithelium and Myeloid Cytokine Hyperinflammatory Response Drive Influenza-Associated Pulmonary Aspergillosis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Heather Conti (University of Toledo, United States) and Teresa Zelante (University of Perugia, Italy)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Early-Career Investigator Presentations
Discussion Leaders: Floyd Wormley (Texas Christian University, United States) and Carol Munro (University of Aberdeen, United Kingdom)
7:30 pm - 7:45 pm
Antonia Akoumianaki (FORTH-IMBB, Greece)
"The Role of IL-6 Signaling in Sepsis-Induced Pulmonary Aspergillosis"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Mark Gresnigt (Leibniz-HKI, Junior research group Adaptive Pathogenicity Strategies, Germany)
"Fungal Adaptations to the Host Environment Dramatically Impact C. Albicans- immune Interactions"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Neta Shlezinger (The Hebrew University, Israel)
"Mycoviruses: The Backseat Drivers of Fungal Diseases"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Marcos Isidoro-Ayza (University of Wisconsin Madison, United States)
"Hijacking Bat Keratinocytes: Mechanistic Insights into the Early Stages of White-Nose Syndrome"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Althea Campuzano (University of Texas at San Antonio, United States)
"Vaccine-Induced Immune Responses to Pulmonary Coccidioidomycosis"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
James Griffiths (King's College London, United Kingdom)
"IL-1: A Central Mediator in Mucosal Candida Disease"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Therapeutic Strategies: From Vaccines to Immunotherapies
Discussion Leaders: Eric Pearlman (University of California, Irvine, United States) and Karen Wozniak (Oklahoma State University, United States)
9:00 am - 9:20 am
Neil Gow (University of Exeter, United Kingdom)
"Characterization of the Mannan Immune Epitope on the Cell Wall of Candida Albicans"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Karen Norris (University of Georgia, United States)
"Advancing a Broadly Protective Vaccine Strategy for the Prevention of Fungal Infections"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
John Galgiani (University of Arizona College of Medicine-Tucson, United States)
"?cps1 : A Gene-Deletion Mutant of Coccidioides posadasii as a Preventative Vaccine Candidate for Dogs"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Sebastian Wurster (The University of Texas MD Anderson Cancer Center, United States)
"Pulmonary Transcriptomics Reveal Immune Dysfunction and Exhaustion in Mice with Invasive Pulmonary Mucormycosis, Partially Restored by PD-L1 Immune Checkpoint Blockade"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Gaurav Bairwa (University of Wisconsin-Madison, United States)
"Lung Epithelial Cells Regulate the Immune Response to Intranasal Vaccination Against Coccidioidomycosis"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Dalia Sheta (Zentrum für Experimentelle Molekulare Medizin/ ZEMM, Universität Würzburg, Germany)
"M-CSF Treatment Enhances Tissue Resident Alveolar Macrophage Function to Protect from Pulmonary Aspergillus fumigatus Infection"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Keyi Wang (Rutgers University, United States)
"Innate Cell Contributions to Vaccine-induced Antifungal Protection."
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Fungi in Oncologic and Immune-Mediated Diseases
Discussion Leaders: Tobias Hohl (Memorial Sloan-Kettering Cancer Center, United States) and Suzanne Noble (UCSF, United States)
7:30 pm - 7:50 pm
Lian Narunsky Haziza (The Weizmann institute of Science, Israel)
"The Tumor Mycobiome"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
David Corry (Baylor College of Medicine, United States)
"Candida albicans -Specific Immune Recognition in Allergic Airway Disease and Cerebral Mycosis"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Petra Bacher (Kiel University, Germany)
"Development of Pathogenic CD4+ T Cell Responses against Fungi in Patients with Inflammatory Bowel Diseases"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Iliyan Iliev (Weill Cornell Medicine, United States)
"Mycobiota-host Immune Interactions at High Resolution: New Implications for Inflammatory Diseases and Cancer"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Darin Wiesner (Rutgers - New Jersey Medical School, United States)
"Inhalation of Aspergillus Alkaline Protease 1 Inures Mice With Permanent Allergen-Specific Immunity and Exacerbated Allergic Lung Inflammation"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
From Bench to Bedside: Translating Fungal Immunity to Patients
Discussion Leaders: Michael Mansour (Massachusetts General Hospital, United States) and Keven Robinson (University of Pittsburgh, United States)
9:00 am - 9:20 am
Kevin Fuller (University of Oklahoma Health Sciences Center, United States)
"Novel Therapeutics for Fungal Keratitis: Looking to the Corneal Environment for Insights"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Jay Kolls (Tulane University School of Medicine, United States)
"Improved Therapeutics and Diagnostics for Pneumocystis Pneumonia"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Dona Love (National Institutes of Health, United States)
"Demystifying the NIH Grant Application Process and Current Funding Opportunities"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Nadja Thielemann (Institut für Hygiene und Mikrobiologie, Germany)
"Genetic IL-17A Variation and Mycobiome Dysbiosis Contribute to Liver Fibrosis in NAFLD Patients"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Leijie Jia (Leibniz Institute for Natural Product Research and Infection Biology, Germany)
"Human p11-Mediated Re-Direction of Phagosomes to the Recycling Endosome-Expulsion Pathway by a Fungal Pathogen"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Jennifer Reedy (Massachusetts General Hospital, United States)
"Aspergillus Melanin Potently Blocks Human Airway Epithelium-Mediated Inflammation"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Elizabeth Okafor (University of Minnesota Medical School, United States)
"Cytotoxic Cells in the CNS of Subjects with Cryptococcal Meningitis and Advanced HIV"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Immunogenetics and Fungal Immunity
Discussion Leaders: Carolina Coelho (MRC Centre for Medical Mycology, United Kingdom) and Mihai Netea (Radboud University Medical Center, The Netherlands)
7:30 pm - 7:50 pm
Vinod Kumar Magadi Gopalaiah (Radboud UMC, The Netherlands)
"Functional Genomics Approaches for Fungal Sepsis: the Genetic Architecture of Susceptibility and Survival Among Fungal Sepsis Patients"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Agostinho Carvalho (University of Minho, Portugal)
"Genetic Determinants of Immunometabolic Responses to Fungal Infection"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Duncan Wilson (University of Exeter, United Kingdom)
"Candida Albicans Pra 1 Zine Scavenger Drive VVC Immunopathology"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Sofia Hain (University of Birmingham, United Kingdom)
"Defining Microglial Heterogeneity in the Fungal-Infected CNS"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Allison Scherer (Massachusetts General Hospital, United States)
"Neutrophils Demonstrate Variation in Transcriptional and Epigenetic Signatures at Homeostasis, Presenting Avenues of Heterogeneity in Response to Candida "
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Innate Immunity in Fungal Infections
Discussion Leaders: Robert Wheeler (University of Maine, United States) and Rebecca Drummond (University of Birmingham, United Kingdom)
9:00 am - 9:20 am
Hortense Slevogt (Medizinische Hochschule Hannover, Germany)
"Differential Effects of Candida albicans-CEACAM Receptor Interaction on Host Response in the Context of Systemic Infection"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Stuart Levitz (University of Massachusetts Chan Medical School, United States)
"Subunit Cryptococcus Vaccines: Immune Correlates of Protection"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Jeniel Nett (University of Wisconsin-Madison, United States)
"Neutrophil Evasion by Candida Auris "
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Lena Heung (Cedars-Sinai Medical Center, United States)
"Decrypting the Monocyte Response to Cryptococcus "
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Michael Lorenz (University of Texas McGovern Medical School, United States)
"New Insights into Candida-macrophage Interactions"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Effector Pathways in Fungal Immunity: Contributions of the Adaptive Immune Response
Discussion Leaders: Michal Olszewski (University of Michigan and VAMC Ann Arbor, United States) and Salomé LeibundGut-Landmann (University of Zurich, Switzerland)
7:30 pm - 7:50 pm
Chiung-Yu Hung (University of Texas at San Antonio, United States)
"Development of a Human Subunit Vaccine Against Coccidioidomycosis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Christina Zielinski (Leibniz Institute for Natural Product Research and Infection Biology, Germany)
"T Cells with Holes – a New Way to Communicate Anti-fungal Host Defence"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Manish Butte (UCLA, United States)
"Maladaptive T Cell Responses in Disseminated Coccidioidomycosis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Priya Uppuluri (The Lundquist Institute, Harbor-UCLA, United States)
"A Spatially Resolved Transcriptomic "Atlas" of Oropharyngeal Candidiasis Reveals a Th-2 and Th-17 Response, Similar to Allergic Inflammation"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Fiorella Ruchti (University of Zurich, Switzerland)
"IL-17A-Producing ?d T Cells Are Critical For Cutaneous Immunity Against Malassezia and Are Directly Activated by Malassezia -Derived Compounds"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure