Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Repurposing of Bioenergetics in Innate Immunity
Discussion Leaders: Catharine Bosio (Rocky Mountain Laboratories, United States)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:10 pm
Luke O'Neill (Trinity College Dublin, Ireland)
"Krebs Cycle Reborn in Macrophage Activation"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Edward Pearce (Johns Hopkins University, United States)
"Lipid Metabolism in Immune Cell Function"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Maxim Artyomov (Washington University, St. Louis, United States)
"Functional Roles of Itaconate and Its Derivatives"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolic Programming of Lymphocyte Function
Discussion Leader: Peer Karmaus (National Institute of Environmental Health Sciences, NIH, United States)
9:00 am - 9:25 am
Mark Boothby (Vanderbilt University Medical Center & Medical School, United States)
"Feast, Famine and Function: Towards Manipulating and Imaging Nutrient Micro-Milieux and Their Impact on Immune Function"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Ming Li (Memorial Sloan Kettering Cancer Center, United States)
"Metabolic Mechanisms of T Cell Immunity and Transformation"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Andrew Patterson (Vanderbilt University Medical Center, United States)
"Identifying Metabolic Regulators of CD4+ T cells Using Mendelian Disease"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Erika Pearce (Johns Hopkins University, United States)
"Polyamine Metabolism Regulates the T Cell Epigenome Through Hypusination"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Claudia Kemper (National Institutes of Health, United States)
"Pace Yourself: Arginine Metabolism Controls Th1 Contraction"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Will Bailis (Children's Hospital of Philadelphia, United States)
"NAD+ Biosynthesis Coordinates the Cell Biology T Cell Clonal Selection"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Claudia Kemper (National Institutes of Health, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metabolic, Epigenetic and Functional Crosstalk in Immunity
Discussion Leader: Nancie MacIver (The University of North Carolina at Chapel Hill , United States)
7:30 pm - 7:55 pm
Mihai Netea (Radboud University Medical Center, The Netherlands)
"Metabolic and Epigenetic Reprogramming in Trained Immunity"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Navdeep Chandel (Northwestern University, United States)
"Mitochondria as Signaling Organelles"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Russell Jones (Van Andel Institute, United States)
"Modulating T Cell Responses Through One-Carbon Metabolism"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Frank Dorsey (Eli Lilly and Company, United States)
"Immunomodulatory Activity of Antibodies that Selectively Bind to and Inhibit the Lactate Transporter MCT1"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Sterols and Other Lipids in Immunity
Discussion Leader: Peter Ghazal (Cardiff University, United Kingdom)
9:00 am - 9:25 am
Steven Bensinger (University of California, Los Angeles, United States)
"Reprogramming Sterol Metabolism as a Host Defense Strategy"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Alan Tall (Columbia University Medical Center, United States)
"Cholesterol and the NLRP3 Inflammasome"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Rebekka Bauer (Goethe-University Frankfurt, Germany)
"Hypoxia-Mediated Disturbances in Cholesterol Metabolism and its Influence on Interferon Signaling and SARS-CoV-2 Infection in Monocytic Cells"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Ping-Chih Ho (University of Lausanne, Switzerland)
"Immunometabolic Editing: The Intersection of Cancer Metabolism and Evolution"
11:25 am - 11:35 am
Discussion
11:35 am - 11:45 am
Jacqueline Turner (University of Colorado Anschutz School of Medicine, United States)
"Lipid Signaling as a Tolerogenic Mechanism to Regulate CD8 T Cell Metabolism and Anti-Tumor Immunity"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Autumn York (Yale University, United States)
"Decoding the Immunological Lipidome"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Yeonseok Chung (Seoul National University, South Korea)
"Fatty Acid Metabolism Controls Autoimmune Diseases"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metabolic Programming in Autoimmune and Inflammatory Diseases
Discussion Leader: Erika Pearce (Johns Hopkins University, United States)
7:30 pm - 7:55 pm
Laurence Morel (University of Florida, U.S. Minor Outlying Islands)
"Metabolic and Microbial Regulation of Lupus"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Cornelia Weyand (Stanford University, United States)
"Metabolic Strategies of T Cells in Autoimmune Disease"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Cheryl Lee (Duke-NUS Medical School, Singapore)
"Mitochondrial Peptide MOCCI Finetunes Complex IV to Modulate Infection Outcomes"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:10 pm
David Finlay (Trinity College Dublin, Ireland)
"Glutamine is Essential for cDC1 Antigen Cross-Presentation"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Xuewei Zhu (Wake Forest School of Medicine, United States)
"Pyruvate Dehydrogenase Kinase Supports Macrophage NLRP3 Inflammasome Activation During Acute Inflammation"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Immunometabolism of the Tumor Microenvironment
Discussion Leader: Brent Hanks (Duke University, United States)
9:00 am - 9:25 am
Gerald Shadel (Salk Institute for Biological Studies, United States)
"Mitochondrial Signaling in Tumor Immune Responses"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Vijay Kuchroo (Harvard Medical School, United States)
"In Silico Modeling of Metabolic State in Single T Cells"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Jason Miska (Northwestern University, United States)
"The Hypoxic Niche in Glioblastoma is Maintained by Myeloid Produced Creatine"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Weiping Zou (University of Michigan, United States)
"Cross-Talk Between Epigenetics and Metabolism in Cancer Immunity and Therapy"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
Juhee Oh (University of British Columbia, BC Children's Hospital Research Institute, Canada)
"Blunting Mitochondrial Complex III ROS Without Altering Respiration Reduces Anti-Tumour Function of Glucose Rstricted CD8+ T Cells"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Li Tang (EPFL, Switzerland)
"Metabolically Armored CAR-T Cells Counter Dysfunction and Promote Stemness for Solid Tumor Clearance"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
David Soto-Pantoja (Wake Forest School of Medicine, United States)
"Metabolic Endpoints as Biomarkers of Immune Checkpoint Therapy Efficacy & Immune-Related Adverse Events"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Metabolism in Host Defense
Discussion Leader: Phillip West (Texas A&M University College of Medicine, United States)
7:30 pm - 7:55 pm
Janelle Ayres (Salk Institute for Biological Studies, United States)
"Host-Microbe Interactions: Harnessing Co-Evolution to Treat Disease"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Peter Ghazal (Cardiff University, United Kingdom)
"The Immune-Metabolic Code of Sepsis in Humans"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Sebastian Riquelme (Columbia University Medical Center, United States)
"Pulmonary Ketogenesis Promotes Tolerance to P. Aeruginosa Infection"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Ira Tabas (Columbia University Irving Medical Center, United States)
"Macrophage Metabolism of Dead Cell Cargo During Efferocytosis"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell Fate in Immunity and Metabolic Disease
Discussion Leader: Lisa Bouchier-Hayes (Baylor College of Medicine, United States)
9:00 am - 9:25 am
Douglas Green (St. Jude Children's Research Hospital, United States)
"Twins Separated at Birth: Polarized Protein Translation and Asymmetric Cell Division in T Cells"
9:25 am - 9:35 am
Discussion
9:35 am - 9:50 am
Hanrui Zhang (Columbia University Irving Medical Center, United States)
"WDFY3 is a Novel Regulator of Macrophage Efferocytosis Required for Both the Uptake and Degradation of Dying Cells"
9:50 am - 9:55 am
Discussion
9:55 am - 10:20 am
Juan Cubillos-Ruiz (Weill Cornell Medicine, United States)
"Immunometabolic Programs Controlled by ER Stress in Tumors"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Gokhan Hotamisligil (Harvard University, United States)
"Organelle Homeostasis and Immunometabolic Regulation in Health and Disease"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
Stefanie K Wculek (CNIC - Spanish National Center for Cardiovascular Research (Carlos III), Spain)
"Oxidative Phosphorylation Selectively Orchestrates Tissue Macrophage Homeostasis"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Julie Magarian Blander (Weill Cornell Medicine, United States)
"Detection and Response to Vita-PAMPs, Signatures of Microbial Viability"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Emerging Opportunities for Intervening Upon Immunometabolism in Disease
Discussion Leaders: Ana Mora (Ohio State University, United States) and Hu Zeng (Mayo Clinic, United States)
7:30 pm - 7:55 pm
Ed Driggers (Rheos Medicines, General Metabolics, United States)
"Immune Cell Metabolism in Patients vs. In Vitro: Developing Marker Strategies to Link Drug Targets with Disease"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Nick Haining (Arsenal Biosciences, United States)
"Reprogramming the Fate and Function of T Cells for Cancer Therapy"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Bruce Blazar (University of Minnesota, United States)
"Exploiting the High Metabolic Requirements of Allogeneic Hematopoietic Transplantation"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
General Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure