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Inhibition in the CNS (GRS)

Gordon Research Seminar

Functional Dynamics of Inhibitory Signaling from Synapses to Behavior

July 6 - 7, 2019
Chairs and
Grand Summit Hotel at Sunday River
97 Summit Road
Newry, Maine, United States
 Venue and Travel Information

Conference Description

The Gordon Research Seminar on Inhibition in the CNS is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange novel data and innovative research ideas.

A major goal of this meeting is to foster discussion and collaborations between junior scientists in the field of inhibitory neuroscience.

Inhibitory neurons perform specialized and dynamic roles in neural circuits for learning and behavior. These specializations arise from their remarkable diversity of molecular, cellular, and synaptic characteristics. This GRS program will showcase research performed at many levels of investigation from young scientists on the functional biology of inhibition in the brain and its dynamic regulation in health and disease.

Related Meeting

This GRS will be held in conjunction with the "Inhibition in the CNS" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Organization of GABAergic Microcircuits in the Hippocampus
Discussion Leader:
3:45 pm - 4:20 pm
"Organization of GABAergic Microcircuits in the Hippocampus"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Molecular, Synaptic and Sub-Synaptic Dynamics of Inhibition
Discussion Leader:
7:30 pm - 7:50 pm
"An Amino Acid Motif Within the GABA-A Receptor a2 Subunit Promotes Inhibitory Synaptogenesis and Seizure Resilience"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Thalamus-Evoked Inhibition Mediates Precise Cellular and Sub-Cellular Control of Prefrontal Projection Neurons"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Local Control of Protein Synthesis for Cortical Inhibitory Wiring"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Acute Stress Usurps mGlu5-Driven Plasticity on Somatostatin Interneurons to Facilitate Bottom-up Processing in the Prefrontal Cortex"
9:20 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Inhibitory Neurons in Circuits, Networks and Behavior
Discussion Leader:
9:00 am - 9:20 am
"mGlu1 Potentiation Enhances Prefrontal Cortical Inhibition via Somatostatin-Expressing Interneurons and Rescues Schizophrenia-Like Behavioral Deficits"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Hippocampal GABAergic Interneurons Bi-Directionally Modulate Sharp-Wave Ripples"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Determining Mechanisms Underlying Hippocampal Network Disruption in Early Amyloid Pathology: The Role of PV+ Cells on Sharp-Wave Ripples"
10:20 am - 10:30 am
Discussion
10:30 am - 10:50 am
"Role of Nitric Oxide Synthase-Expressing GABAergic Neurons of the Mouse Amygdala on Sleep"
10:50 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Non-Traditional Roles of Inhibition
Discussion Leader:
1:30 pm - 1:50 pm
"Loss of Inhibitory Interneurons and Synaptic Alterations in Multiple Sclerosis"
1:50 pm - 2:00 pm
Discussion
2:00 pm - 2:20 pm
"PV+-Astrocyte Signaling Modulates Cortical Inhibitory Synaptic Activity"
2:20 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes

Contributors

National Institutes of Health
Scientifica Ltd

University of Minnesota - Bob Allison Ataxia Research Center (BAARC)

University of Minnesota - Minnesota

Research reported in this publication was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R13NS111916. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conference Links

Conference History Inhibition in the CNS
Additional Fee Info

Inhibition in the CNS
July 6 - 11, 2025


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