SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | IGFs: History and Future |
| Discussion Leader: Derek LeRoith - NIH |
7:30 pm - 8:10 pm | C.Ron Kahn - Joslin Diabetes Center "Deletions of IRS & Insulin Receptor Genes in Mice" |
8:10 pm - 8:30 pm | Discussion |
8:30 pm - 9:10 pm | Renato Baserga - Jefferson Medical College "IGFs in Cell Survival & Cancer" |
9:10 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am -12:30 pm | Cancer - Epidemiology & Basic Mechanisms |
| Discussion Leader: Doug Yee - University of Minnesota |
9:00 am - 9:30 am | Michael Pollak - McGill University "Cancer Risk & the IGFs" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Marina Guvakova - U. Penn "Mechanisms of IGF-I stimulated cell motility: When a growth factor becomes a scatter factor" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Group Photo and Coffee Break |
10:30 am - 11:00 am | Sue Hankinson -Harvard Medical School "IGFs & Breast Cancer Risk" |
11:00 am - 11:15 am | Discussion |
11:15 am - 11:45 am | Charles Roberts - Oregon Health and Science University "IGF Action in Prostate Cancer Progression" |
11:45 am -12:00 pm | Discussion |
12:00 pm - 12:15 pm | Deepali Sachdev - U. Minn "A dominant-negative IGF-IR inhibits metastasis of breast cancer cells" |
12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30-9:30 pm | IGF Signaling |
| Discussion Leader: Kim Heidenreich - Colorado Health Sciences Center |
7:30 pm - 8:00 pm | Rosemary O'Connor - National University of Ireland "IGF-I Receptor Signaling" |
8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | David Clemmons - UNC Chapel Hill "IGF Receptor and ECM Signaling" |
8:45 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | Daniel Linseman - U. Colorado "IGF-I blocks neuronal apoptosis by inhibiting Bim induction and bax translocation to mitochondria"
|
9:15 pm - 9:25 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am -12:30 pm | Clinical Aspects and Mutations |
| Discussion Leader: David Clemmons - UNC Chapel Hill |
9:00 am - 9:30 am | Greet van den Berghe - Univ Leuven, Belgium "IGFs & Catabolic Disorders" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Alan Moses - Joslin Diabetes Medical Center "IGFs in Diabetes" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Cecilia Camacho-Hubner - St. Bartholomews Hospital, London "Human IGF-I Mutations" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:00 pm | Vincent Geenan - Liege U. "Thymic IGF-2 and central self-tolerance of the insulin family: A valuable basis for the development of a tolerogenic vaccine against type 1 diabetes" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm -12:20 pm | Dale Ludwig - ImClone Systems Inc. "Targeted inhibition of the IGF-IR" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Transgenic & Knockout Approaches |
| Discussion Leader: Terri Wood - Penn State College of Medicine |
7:30 pm - 8:00 pm | Derek LeRoith - NIH "KO Mouse Models: The role of circulating IGF-I and cancer of the colon and breast" |
8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Mimo Accili - Columbia University "Specificity of Insulin and
IGF-I Receptor Signaling: Insights from Mutant Mice" |
8:45 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | Joan Carboni - Bristol Myers Squibb Research Institute "Constitutive activation of the IGF-IR: transgenic model for tumor development" |
9:15 pm - 9:25 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am -12:30 pm | IGFBPs |
| Discussion Leader: Pinchas Cohen - UCLA |
9:00 am - 9:30 am | Jeff Holly - Bristol Royal Infirmary, UK "Apoptotic mechanisms in Breast Cancer" |
9:30 am - 9:45 am | Discussion |
9:45 am -10:15 am | Rob Baxter - Kolling Inst of Med Research, Australia "IGFBP Proteolysis and Ligand Binding" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Cheryl Conover - Mayo Clinic, Rochester "IGFBP-4 Protease" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:00 pm | Laura Cobb - U. Cambridge "IGF-dependent and IGF-independent actions of IGFBP-5 in myogenesis" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Claire Perks - U. Bristol "An IGF-independent role for IGFBP-5 in the induction of apoptosis during involution of the mammary gland" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm -9:30 pm | Gene Transcription and Regulation |
| Discussion Leader: Martin Adamo - UT Health Sciences Center |
7:30 pm - 8:00 pm | Peter Rotwein - Oregon Health and Science University "IGF-I Gene Transcription" |
8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Haim Werner - Tel Aviv University "IGF-IR gene transcription regulation by BRCA1 and p53" |
8:45 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | Andrea Morrione - Kimmel Cancer Center "Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the IGF-IR" |
9:15 pm - 9:25 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am -12:30 pm | IGFs/IGFBPs in Development & Tissue Function |
| Discussion Leader: Jenny Pell - (UK) |
9:00 am - 9:30 am | David Hill - Lawson Research Institute "IGFs in Pancreatic Development" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Terri Wood - Penn State College of Medicine "Function of the IGF-IR in Mammary Development and Implications for Breast Cancer" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | John Pintar - UMDNJ, Piscataway "IGFBPs in Fetal Growth & Development" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Cliff Rosen - St. Joseph Hospital, Bangor, Maine "Role of IGF-I in Regulation of Bone Density" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Flora de Pablo - Centro de Investigaciones Biologicas, Madrid "Olfactory bulb stem cells proliferate in response to insulin-related factors and require endogenous IGF-I for differentiation into neurons and glia" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Newly Emerging Topics: Aging & Life-Span |
| Discussion Leader: Victor Han, Lawson Research Institute, Ontario |
7:30 pm - 8:10 pm | Robert Garafalo - Pfizer "Insulin-receptor Homolog & lifespan in Drosophila" |
8:10 pm - 8:30 pm | Discussion |
8:30 pm - 9:10 pm | Cynthia Kenyon - UCSF "Regulation of lifespan in C.elegans" |
9:10 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |