The insulin-like growth factors were originally described as mediators of the effects of growth hormone on the somatic growth of mammals. It has subsequently become clear that they play a more general critical role in integrating growth, development and lifespan according to metabolic conditions. With such a pivotal role, research into IGFs has become of increasing relevance to many of the major health issues currently being addressed including cancer, diabetes, cardiovascular disease, aging and neurodegeneration. This conference will focus on recent developments in IGF-research across a broad range of physiology and pathology, covering aspects from basic biology through to clinical interventions.