SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:50 pm | Welcome / Introductory Comments by GRC Site Staff |
7:50 pm - 9:30 pm | KEYNOTE: IGFS AFTER 50 YEARS |
| Discussion Leader: Rosemary O’Connor (University College Cork, Ireland) |
7:50 pm - 8:50 pm | Derek LeRoith (Mount Sinai School of Medicine) "Growth, metabolism, aging, and cancer: IGF actions in human physiology and disease" |
8:50 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | STRESS, AGING, AND IGF ACTIONS |
| Discussion Leader: Terri Wood (University of Medicine and Dentistry, NJ) |
9:00 am - 9:25 am | Deborah Muoio (Duke University) "Stress responses in skeletal muscle" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Morris White (Harvard University Medical School) "CNS control of aging via IRS-2" |
10:05 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:20 am | Nir Barzilai (Albert Einstein College of Medicine) "IGF signaling and aging humans" |
11:20 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Richard Loeser (Wake Forest University Medical Center) "Reactive oxygen species inhibit IGF-I induction of chondrocyte proteoglycan synthesis through differential regulation of PI-3 kinase - Akt and Erk signaling pathways" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Elaine O’Neill (University of Liverpool) "Does insulin resistance cause accelerated aging of skeletal muscle?" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 1 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | IGF SIGNALING PATHWAYS IN REGENERATIVE MEDICINE |
| Discussion Leader: Rosemary O’Connor (University College Cork, Ireland) |
7:30 pm - 8:00 pm | Nadia Rosenthal (European Molecular Biology Laboratory) "Muscle regeneration" |
8:00 pm - 8:20 pm | Discussion |
8:20 pm - 8:50 pm | Thomas Clemens (University of Alabama Birmingham) "Bone remodeling and repair" |
8:50 pm - 9:10 pm | Discussion |
9:10 pm - 9:20 pm | Westley Friesen (PTC Therapeutics) "Modulating IGF-I levels with small molecules for treatment of Duchenne muscular dystrophy" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | IGF SIGNALING IN METABOLIC REGULATION AND GROWTH |
| Discussion Leader: Shoshana Yakar (Mount Sinai School of Medicine) |
9:00 am - 9:25 am | Kenneth Walsh (Whitaker Cardiovascular Institute, Boston U School of Medicine) "Metabolic signaling by Akt" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Domenico Accili (Columbia University School of Medicine) "FoxO proteins and metabolism" |
10:05 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:20 am | Mario Pende (Université Paris Descartes Faculté de Médecine) "S6 kinases and AMPK in metabolism" |
11:20 am - 11:40 am | Discussion |
11:40 am - 12:10 pm | Steven Kliewer (University of Texas Southwestern Medical Center) "FGF21 in metabolic regulation and growth" |
12:10 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 1 (continued) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | REGULATION OF IGF LIGANDS |
| Discussion Leader: Martin Adamo (University of Texas Health Science Ctr, San Antonio) |
7:30 pm - 8:00 pm | Anna Polesskaya (CNRS FRE 2944, Villejuif, France) "Regulation of IGF-II production by microRNAs" |
8:00 pm - 8:20 pm | Discussion |
8:20 pm - 8:50 pm | Honglin Jiang (Virginia Tech University) "Control of IGF-I gene expression by GH" |
8:50 pm - 9:10 pm | Discussion |
9:10 pm - 9:20 pm | Briony Forbes (University of Adelaide, Australia) "In vivo regulation of IGF-I production and function by 14-3-3" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | IGF ACTIONS IN CANCER |
| Discussion Leader: Adrian Lee (Baylor College of Medicine) |
9:00 am - 9:25 am | Alex Toker (Harvard University Medical School) "Tumorigenesis and cancer progression" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Val Macauley (University of Oxford, UK) "Signaling cross-talk and cooperation with oncogenes" |
10:05 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:20 am | Douglas Yee (University of Minnesota) "Targeted therapeutics" |
11:20 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Marina Guvakova (University of Pennsylvania School of Medicine) "Rap1 is a novel target of the IGF-I receptor in breast cancer" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Michael Pollak (McGill University, Canada) "Insulin, IGF-I, and cancer: some new surprises" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 2 |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | IGF BINDING PROTEINS |
| Discussion Leader: Cheryl Conover (Mayo Clinic) |
7:30 pm - 8:00 pm | John Pintar (University of Medicine and Dentistry, NJ) "What have gene knockouts taught us about IGFBP functions" |
8:00 pm - 8:20 pm | Discussion |
8:20 pm - 8:50 pm | Zee Upton (Queensland University of Technology, Australia) "IGFBPs and extra-cellular matrix" |
8:50 pm - 9:10 pm | Discussion |
9:10 pm - 9:20 pm | Masanobu Kawai (Maine Medical Center) "IGFBP-2 regulates bone turnover through a mechanism independent of IGF-I binding" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | IGF SIGNALING IN CARDIOVASCULAR BIOLOGY |
| Discussion Leader: David Clemmons (University of North Carolina) |
9:00 am - 9:25 am | Kathleen Martin (Dartmouth Medical School) "IGF signaling and vascular smooth muscle differentiation" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Laura Maile (University of North Carolina) "Metabolic control of IGF action in vascular smooth muscle" |
10:05 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:20 am | Jonathan Schisler (University of North Carolina) "Signaling pathways in myocardial hypertrophy" |
11:20 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Eileen Hsu (University of Pittsburgh Medical Center) "IGF-II contributes to fibrosis in systemic sclerosis-related pulmonary fibrosis via the insulin receptor" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Yusuke Higashi (Tulane University School of Medicine) "IGF-I regulates glutathione peroxidase expression and activity in vascular endothelial cells: implications for the athero-protective actions of IGF-I" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 2 (continued) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | STRENGTH, FRAILTY, ATHLETIC PERFORMANCE AND DOPING |
| Discussion Leader: Jeff Holly (University of Bristol, UK) |
7:30 pm - 7:55 pm | Bernhard Maier (Indiana University School of Medicine) "Maintaining muscle mass and strength during aging" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Bradley Nindl (US Army Research Institute of Environmental Medicine, Natick, MA) "The GH - IGF system in athletic performance" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Christian Strasburger (Charité-Universitätsmedizin, Campus Mitte, Berlin, Germany) "GH and IGFs in doping" |
9:15 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |