SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:45 pm | Welcome / Introductory Comments by GRC Site Staff |
7:45 pm - 9:30 pm | Keynote: IGF Receptor Mutations |
| Discussion Leader: Robert J.Smith (Brown University) |
7:45 pm - 8:45 pm | Wieland Kiess (University of Leipzig) "Lessons for Human IGF Function from IGF Receptor Mutations" |
8:45 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | IGFs in somatic growth, regeneration, and ageing |
| Discussion Leader: Derek Le Roith (Mount Sinai School of Medicine) |
9:00 am - 9:25 am | Peter Rotwein (Oregon Health and Science University) "IGF-I gene regulation by growth hormone: new insights and hypotheses" |
9:25 am - 9:45 am | Discussion |
9:45 am - 9:55 am | Short Talk: Briony Forbes (University of Adelaide) "Control of cell growth and survival via 14-33ζ and Type I Insulin-Like Growth Factor Receptor" |
9:55 am - 10:00 am | Discussion |
10:00 am | Group Photo / Coffee Break |
10:30 am - 10:55 am | Maria Grant (University of Florida) "IGFs in Angiogenesis and Retinopathy" |
10:55 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Heidi Scrable (Mayo Clinic) "IGF signalling in Embryonic Stem Cells" |
11:45 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Short Talk: Anne Breggia (Maine Medical Center Research Institute) "The Heparin Binding Domain of IGFBP-2 is an Important Regulator of Murine Hematopoiesis and Human Stem Cell Proliferation" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Stress responses and energy sensing |
| Discussion Leader: Laura Cobb (University of California, Los Angeles) |
7:30 pm - 7:55 pm | Valter Longo (University of Southern California) "IGFs and Cellular protection" |
7:55 pm - 8:15 pm | Discussion |
8:15 pm - 8:30 pm | Marc Tatar (Brown University) "Phosphoprotemic analysis of Drosophila cells stimulated by Insulin/IGF peptide" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 8:50 pm | Desmond Mascarhenas (Mayflower organization for Research and Education) "IRS proteins at the nexus of metabolic disease, cancer and ageing" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | Jessica Mader (Mayo Clinic) "Oxidative Stress Resistance in the Long-lived PAPP-A KO Mouse" |
9:15 pm - 9:25 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Signalling pathways and regulation |
| Discussion Leader: Laura Maile (University of North Carolina) |
9:00 am - 9:25 am | Davide Ruggero (University of California, San Francisco) "Akt, mTor and translation in cell growth" |
9:25 am - 9:45 am | Discussion |
9:45 am - 9:55 am | Short Talk: Aditi Mukherjee (Oregon Health and Science University) "Akt isoforms have distinct roles in BMP-mediated osteogenesis" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | Olle Larrson (Karolinska Institute) "IGF-I Receptor SUMOlyation: potential biological roles" |
10:55 am - 11:20 am | Discussion |
11:20 am - 11:35 am | Short Talk: Piers D. Nash (University of Chicago) "A Broad Range of Novel SH2 Domain-Mediated Signaling Pathways may arise from the IGF-I Receptor" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:00 pm | Short Talk: Shin-Ichiro Takahashi (University of Tokyo) "Ubiquitin ligase Nedd4 recruits insulin receptor substrate (IRS)-2 to membrane fractions, enhancing IRS-2-mediated signals followed by mitogenic bioactivity of insulin-like growth factors (IGFs" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Short Talk: Mindy Chao (Murdoch Childrens Research Institute, Melbourne) "Dissecting the IGF-I and FGF-2 Crosstalk in Neuronal Differentiation: Signaling Pathways and the Regulation of EWS/Fli1 and downstream target p21WAF1/Cip1" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Ligand and receptor regulation |
| Discussion Leader: Robert Baxter (University of Sydney) |
7:30 pm - 7:55 pm | Marek Brzozowski (University of York) "Molecular crossroads of insulin and IGF-I: Implications of high-affinity insulin analogues for IGF studies" |
7:55 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Antonino Belfiore (University of Catanzaro) "Novel mechanisms of IGF-IR Up-regulation in cancer" |
8:45 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Short Talk: Deirdre Buckley (University College Cork) "Molecular basis for regulation of kinase activity by the C terminus of the IGF-IR" |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Neural function and neurodegeneration |
| Discussion Leader: Terri Wood (New Jersey Medical School / UMDNJ) |
9:00 am - 9:25 am | Derek Van der Kooy (University of Toronto) "Pancreatic stem cells and the evolution of the pancreas from the brain" |
9:25 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Short Talk: John Pintar (RWJMS-IMDNJ) "Dendritic organization and arborization of cortical projection neurons is altered in IGFBP-3 KO mice" |
9:55 am - 10:05 am | Discussion |
10:05 am | Coffee Break |
10:35 am - 11:00 am | Andrew Dillin (Salk Institute) "IGFs in Alzheimer’s disease" |
11:00 am - 11:20 am | Discussion |
11:20 am - 11:35 am | Short Talk: Cora O’Neill (University College Cork) "Defective IGF-I and Insulin signaling are central to neurodegeneration in Alzheimer’s disease" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:10 am | Friedrich Metzger (Hoffman la Roche, Ltd.) "PEGylation can overcome treatment limitations for insulin-like growth factor I in CNS disorders" |
12:10 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | IGF Binding Proteins |
| Discussion Leader: Cunming Duan (University of Michigan) |
7:30 pm - 7:55 pm | Cheryl Conover (Mayo Clinic) "PAPP-A" |
7:55 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Leon Bach (University of Melbourne) "Recent insights into IGFBP-6 actions" |
8:45 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Li Zeng (University of Bristol) "IGFBP2: A Novel Regulator or ERa in breast cancer?" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Marc Becker (Mayo Clinic) "IGFBP5 confers resistance to IGF targeting and correlates with increased invasion and poor overall survival in breast tumors" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | IGFs and Cancer |
| Discussion Leader: Andrea Morrione (Jefferson University) |
9:00 am - 9:25 am | Linda Schuler (University of Wisconsin) "Prolactin and IGF crosstalk in breast cancer" |
9:25 am - 9:45 am | Discussion |
9:45 am - 9:55 am | Short Talk: Hanna Irie (Mount Sinai School of Medicine) "Identification of novel regulators of IGF-1 induced anchorage independent survival of breast epithelial cells" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | Pnina Brodt (McGill University, Montreal) "Multipronged regulation of the tumor microenvironment by the IGF axis" |
10:55 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Ruslan Novosyadlyy (Imclone Systems, Inc) "Challenges in targeting the IGF-IR in cancer" |
11:45 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Short Talk: Katia Scolandi (University of Bologna) "Molecular Mechanisms of Resistance to anti-IGF-IR therapies in Ewing’s sarcoma" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Modulating IGF actions for therapeutic benefit: Issues for the future |
| Discussion Leader: Jeff Holly (Bristol University) |
7:30 pm - 8:00 pm | Kirsten Limesand (University of Arizona, Tucson) "IGFs and protection from chemotherapy" |
8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:25 pm | Short Talk: Abhishek Kashiyap (Queensland University of Technology) "IGF-I: Vitronectin interactions modulate changes in expression of genes which induce breast cancer cell survival, migration and EMT" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 9:00 pm | Parth Patwari (Harvard Medical School) "Engineered IGFs and cartilage" |
9:00 pm - 9:20 pm | Discussion |
9:30 pm | Reception |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |