| Sun
30/7 | 1: INTEGRATING INTERMEDIATE FILAMENTS IN TISSUES (GEOGRAPHY DEPARTMENT) |
| 1915 | Don Cleveland (Session chair)
Ludwig Institute for Cancer Research, La Jolla, USA
Neurofilament-dependent axonal growth and death: order and disorder in the axoplasm |
| 1930 | Thomas Magin
Institute of Genetics, Bonn, Germany
Dual function of keratins: Novel insights from knockout mice |
| Pierre Coulombe
John Hopkins University, Baltimore, USA
Properties and functions of keratin filaments in skin |
| 2010 | DISCUSSION |
| 2030 | David Garrod
School of Biological Sciences, Manchester, UK
Desmosomes and epithelial morphogenesis |
| 2050 | Arnoud Sonnenberg
Netherlands Cancer Institute, Amsterdam, Netherlands
Integrin a6b4-mediated cell adhesion: The cytoskeletal connection |
| 2110 | DISCUSSION |
| 2130 | DRINKING AND DISCUSSION QUEEN'S COLLEGE CLOISTERS & BAR |
| Mon 31/7 | 2: PATHOLOGY OF THE INTERMEDIATE FILAMENT CYTOSKELETON (GEOGRAPHY DEPT) |
| 0900 | Jean-Pierre Julien (Session chair)
Montreal General Hospital Research Institute, Canada
Neuronal filament aggregates in motor neurone disease: Protective or detrimental effects? |
| 0915 | Ammar Al-Chalabi
Institute of Psychiatry, Kings College, London, UK
Neurofilament gene mutations and motor neurone disease |
| 0935 | Dennis Roop
Baylor College of Medicine, Houston, USA
Inducible activation of EBS and EHK mutant alleles in transgenic mice: an explanation for the absence of mosaic forms of EBS |
| 0955 | DISCUSSION |
| 1015 | Coffee Break |
| 1035 | Juliet Ellis
Addenbrookes Hospital, Cambridge, UK
Muscular dystrophies, diabetes & dilated cardiomyopathy: the nuclear connection |
| 1055 | Dewi Owens
University of Dundee, Dundee, UK
Keratin mutations in inflammatory bowel disorders |
| 1115 | DISCUSSION |
| 1135 | Denise Paulin
University of Paris 7, France
Regulation of intermediate filaments in smooth and striated muscle |
| 1155 | Rob Bellin
Iowa State University, Ames, USA
Properties and possible functions of synemin and paranemin |
| 1215 | DISCUSSION |
| 1245 | Official photograph QUEEN'S COLLEGE |
| 1300 | LUNCH QUEEN'S COLLEGE |
| 1400-1600 | FREE TIME |
| 1600 | POSTER SESSION QUEEN'S COLLEGE |
| 1800 | DINNER QUEEN'S COLLEGE |
| Mon
31/7 | 3: INTERMEDIATE FILAMENTS AND MOVEMENT
(GEOGRAPHY DEPT) |
| 1915 | Bob Goldman (Session chair)
Northwestern University Med. School, Chicago, USA
Intermediate filaments on the move |
| 1930 | Lexie Friend University of Queensland, St. Lucia, QLD, Australia
A conserved region of type II keratins mediates cytoplasmic tethering and transport of intermediate filament precursors |
| 1940 | Christine Gilles
University of Liège, France
Contribution of vimentin to human epithelial cell migration: implication in tumour invasion |
| 2000 | DISCUSSION |
| Tom Shea
University of Massachusetts, Lowell, USA
Regulation of neurofilament axonal transport |
| 2040 | Ben Szaro Biological Sciences, University at Albany, SUNY, USA
Loss of neurofilaments alters the growth dynamics of developing neurites in cultures of embryonic Xenopus laevis spinal cords |
| 2050 | Greg Gundersen
Columbia University, New York, USA
Vimentin dynamics and interactions with
microtubules |
| DISCUSSION |
| 2130 | DISCUSSION & DRINKING QUEEN'S COLLEGE CLOISTERS & BAR |
| Tues
1/8 | 4: POST-TRANSLATIONAL MODIFICATION OF INTERMEDIATE FILAMENTS & CELL SIGNALLING (GEOGRAPHY DEPT) |
| 0900 | John Eriksson (Session chair)
Turku Centre for Biotechnology,
Turku, Finland
Phosphorylation of intermediate filaments - Implications for turnover, signalling, and stress responses |
| 0920 | Harish Pant
National Institute of Health, Bethesda, USA
Signal transduction and neurofilament phosphorylation |
| 0940 | Bishr Omary
Stanford University School of Medicine, USA
Regulation, turnover and functional perspectives of simple epithelial keratins |
| 1000 | DISCUSSION |
| 1020 | Coffee Break |
| 1040 | Jesus Paramio
CIEMAT, Madrid, Spain
Akt and PKCz are involved in keratin K10-mediated cell cycle arrest |
| 1100 | Miki Blumenberg
NYU Medical Centre, New York, USA
Regulation of keratin synthesis in epidermal inflammation |
| 1120 | DISCUSSION |
| 1140 | Cecilia Sahlgren Turku Centre for Biotechnology, Turku, Finland
The role of cyclin-dependent kinases in phosphorylation-based regulation of nestin organization during normal and regenerative processes |
| 1150 | Sue Shackleton Genetics Department, University of Leicester, UK
Partial lipodystrophy is caused by mutations in the LMNA gene, encoding nuclear lamins A and C |
| 1200 | Yassemi Capetanaki Dept of Molecular & Cell Biology, Baylor College of Medicine, Houston, USA
Defferential gene expression of extracellular matrix components in the dilated heart of desmin null mice |
| 1210 | DISCUSSION |
| 1230 | LUNCH QUEEN'S COLLEGE |
| 1400-1600 | FREE TIME |
| 1600 | POSTER SESSION
QUEEN'S COLLEGE |
| 1800 | DINNER
QUEEN'S COLLEGE |
| Tues | 5: INTERMEDIATE FILAMENTS AND THE STRESS RESPONSE (GEOGRAPHY DEPT) |
| 1915 | Roy Quinlan (Session chair)
University of Dundee, Dundee, UK
Role of protein chaperones in intermediate filament function |
| 1930 | Irwin McLean
Human Genetics Unit, Ninewells Hospital, Dundee, UK
Proteins that interact with the V1 domain of keratin 7 |
| 1950 | Bob Oshima
The Burnham Institute, La Jolla, USA
K8 and K18 moderate TNF mediated epithelial apoptosis |
| 2010 | DISCUSSION |
| 2030 | Milos Pekny
University of Göteborg, Göteborg, Sweden
Function of intermediate filaments in
astrocytes |
| 2050 | Kurt Zatloukal
Institute of Pathology, Graz, Austria
Cytokeratins as targets and modulators of chronic stress responses |
| 2110 | DISCUSSION |
| 2130 | DISCUSSION & DRINKING QUEEN'S COLLEGE CLOISTERS & BAR |
| Wed
2/8 | 6: INTERMEDIATE FILAMENT STRUCTURE AND ASSEMBLY (GEOGRAPHY DEPT) |
| 0900 | Peter Steinert (Session chair)
NIH, Bethesda, USA
The challenge of intermediate filament structure |
| 0915 | David Parry
Massey University, Palmerston, New Zealand
Trichocyte keratin: molecular rearrangement, a head-to-tail gap between parallel molecules, evidence for protofibrils, and disulphide intra-intermediate filament stabilisation |
| 0935 | Harald Herrmann
DKFZ, Heidelberg, Germany
Structural mechanisms underlying the assembly of intermediate filaments |
| 0955 | DISCUSSION |
| 1015 | Coffee Break |
| 1035 | Jure Stojan
Medical Centre for Molecular Biology, Ljubljana, Slovenia
Homology structural model of 1A portion of K5-K14 heterodimer |
| 1055 | Sergei Strelkov
Maurice E Muller Institute, Basel, Switzerland
'Divide-and-conquer' crystallographic approach towards an atomic structure of intermediate filaments |
| 1115 | DISCUSSION |
| 1135 | John Hess UCSD School of Medicine
Use of SDSL-EPR to study intermediate filament assembly |
| 1145 | Norbert Mucke DKFZ, Heidelberg, Germany
Investigating the state of soluble intermediate filament protein complexes with the analytical ultracentrifuge |
| 1155 | John Mathew Harvard Medical School, USA
Expression of periphin in rhesus macaques occurs in astrocytes rather than neurons and is associated with encephalitis |
| 1205 | DISCUSSION |
| 1230 | LUNCH |
| 1400-1600 | FREE TIME |
| 1600 | POSTER SESSION
QUEEN'S COLLEGE |
| 1800 | DINNER QUEEN'S COLLEGE |
| Wed
2/8 | 7: NUCLEAR INTERMEDIATE FILAMENTS
(GEOGRAPHY DEPT) |
| 1915 | Chris Hutchison (Session chair)
University of Durham, Durham, UK
Lamin A/C interacting partners and cellular complexes |
| 1930 | Frans Ramaekers
University of Limburg, Maastricht, The Netherlands
Dynamics of the nuclear lamina |
| 1950 | Brian Burke
University of Calgary, Calgary, Canada
Nuclear lamins, muscular dystrophy and the maintenance of nuclear architecture |
| 2010 | DISCUSSION |
| 2030 | Reimer Stick
DKFZ, Heidelberg, Germany
Lamin membrane interactions |
| 2050 | Eric Schirmer
Scripps Research Institute, La Jolla, USA
Role of the lamin rod domain in lamina and nuclear organization |
| 2110 | DISCUSSION |
| 2130 | DISCUSSION & DRINKING QUEEN'S COLLEGE CLOISTERS & BAR |
| Thur 3/8 | 8: FILAMENT NETWORKING PROTEINS IN THE CYTOPLASM (GEOGRAPHY DEPT) |
| 0900 | Werner Franke (Session chair)
DKFZ, Heidelberg, Germany
Plakophilins and their double life in the nucleus and in junctions |
| 0920 | Kathy Green
Northwestern University Med. School, Chicago, USA
Plakins and plakophilins in desmosome assembly |
| 0940 | Jonathan Jones
Northwestern University Med. School, Chicago, USA
A novel vimentin-associated matrix
junction: Structure and function in endothelial cells |
| 1000 | DISCUSSION |
| 1020 | Coffee Break |
| 1040 | Gerhard Wiche
University of Vienna Biocentre, Vienna, Austria
Plectin isoform diversity and novel binding partners |
| 1100 | Ron Liem
Columbia University, New York, USA
Multiple cytoskeletal linker functions of plakins in the nervous system |
| 1120 | DISCUSSION |
| 1140 | Zendra Zehner Virginia Commonwealth University, Richmond, USA
Identification of human vimentin 3'UTR-binding proteins involved in mRNA perinuclear localization using the yeast 3-hybrid method |
| 1150 | Teresa Di Colandrea ICRF Laboratories, London, UK
Analysis of subcellular localizations of periplakin and envoplakin |
| 1200 | Elizabeth Sztul University of Alabama at Birmingham, Alabama, USA
A novel type of regulation of the vimentin IF cytoskeleton by a Golgi protein |
| 1210 | DISCUSSION |
| 1245 | LUNCH |
| 1400-1600 | FREE TIME |
| 1600 | BUSINESS MEETING
(election of next vice chair) QUEEN'S COLLEGE JCR |
| 1700 | drinks QUEEN'S COLLEGE CLOISTERS & BAR |
| 1800 | BANQUET QUEEN'S COLLEGE |
| Thur
3/8 | EVOLUTION OF INTERMEDIATE FILAMENTS (GEOGRAPHY DEPT) |
| 2000 | Klaus Weber (Session chair)
Max Planck Inst. for Biophysical Chemistry, Göttingen, Germany
The molecular evolution of the metazoan intermediate filaments multigene family |
| 2020 | Nick Brown
Wellcome/CRC Laboratories, Cambridge, UK
Genetic dissection of integrin adhesive junctions in Drosophila. ("Why don't flies have intermediate filaments?") |
| 2040 | Jürgen Schweizer
German Cancer Research Centre, Heidelberg, Germany
Hair keratins and human evolution |
| 2100 | DISCUSSION |
| 2120 | FINAL DISCUSSIONS
& FINAL DRINKING QUEEN'S COLLEGE CLOISTERS & BAR |
| Fri
4/8 |
| Departure after breakfast |
