| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Perspective Talks |
| Discussion Leader: Gary Borisy (Northwestern University) |
| Gary Borisy (Northwestern University, Chicago)
"Actin-driven cell locomotion: From signals to movement" |
| Nobutaka Hirokawa (Tokyo Univ., Japan)
"Molecular mechanism of intracellular transport" |
| Murray Stewart (MRC, Cambridge, UK)
"Molecular mechanism of amoeboid motility" |
| Donald Ingber (Harvard Univ., Boston)
"Cytoskeleton, force transduction and control of cell physiology" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Atomic Structure of IFs: FRom models to reality |
| Discussion Leader: Harald Herrmann (Heidelberg, Germany) |
| Peter Burkhard (Univ. Basel, Switzerland)
"Implications of coiled-coil formation on IF assembly" |
| Harald Herrmann (German Cancer Res. Ctr, Heidelberg, Germany)
"Molecular interactions mediating IF assembly" |
| Ueli Aebi (Univ. Basel, Switzerland)
"The challenges of understanding IF structure" |
| Kathy Green (Northwestern)
Structural insight into desmoplakin-IF interactions |
| Paul Janmey (U Penn)
Self-assembly, rheology and structure of neuronal IFs |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | IF functions in C. elegans, in muscle, and in neurons |
| Discussion Leader: Don Cleveland (Ludwig Institute, San Diego) |
| Anton Karabinos (MPI, Göttingen, Germany)
"At least four cytoplasmic IF proteins are essential for the development of the nematode C. elegans" |
| Yassemi Capatanaki (Baylor College of Medicine, Houston, Tx)
"Desmin cytoskeleton and mitochondrial behavior and function " |
| Don Cleveland (Ludwig Institute, San Diego)
"Mechanism of neurofilament-dependent structuring of axoplasm determined by gene replacement in mice of NF-M and NF-H" |
| Jean-Pierre Julien (McGill Univ., Canada)
"Neuronal loss induced by peripherin deregulation" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Laminopathies, lamin function(s), and nuclear envelope |
| Discussion Leader: Bob Goldman (Northwestern Univ., Chicago) |
| Yosef Gruenbaum (Hebrew Univ., Israel)
"Functional dissection of the nuclear lamina" |
| Gisele Bonne (Paris, France)
"Clinical and genetic heterogeneity of laminopathies" |
| Colin Stewart (NCI, Bethesda)
"Function of lamins in mouse" |
| Roland Foisner (Biocenter, Univ. Vienne, Austria)
"LAP2 proteins in cell proliferation and nuclear assembly: Implications for laminopathies" |
| Kathy Wilson (Johns Hopkins Univ., Baltimore)
"Role of the DNA-bridging protein BAF in lamin organization" |
| Bob Goldman (Northwestern Univ., Chicago)
"Nuclear Lamins: Molecular Building blocks of nuclear organization and function" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | IF-associated cytolinkers: Mechanical integration and other functions |
| Discussion Leader: Gerhard Wiche (Biocenter, Univ. Vienna, Austria) |
| David Garrod (Manchester, UK)
"Structure and function of desmosomes" |
| Yanmin Yang (Stanford Univ., Palo Alto)
"BPAG1, the sensory neuron sustainer" |
| Ron Liem (Columbia Univ., New York)
"MACF, a versatile cytoskeletal linker protein" |
| Gerhard Wiche (Biocenter, Univ. Vienna, Austria)
"Plectin isoform functions in knock out mice and cells" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | IFs and cell and tissue mechanics |
| Discussion Leader: Denis Wirtz (Johns Hopkins Univ., Baltimore) |
| Steve Shoelson (Harvard)
"Structure of lamin's globular tail domain" |
| Peter Davies (Univ. Pennsylvania, Philadelphia)
"Endothelial cytoskeletal displacement in response to flow as a component of the decentralized model of mechanotransduction" |
| Ning Wang (Harvard Univ., Boston)
"Prestress and cytoskeletal stiffness: role of IFs" |
| Laurent Kreplak (Centre Univ. Paris-Sud, France)
"Mechanical behavior of hard alpha-keratin IFs in hair tissue" |
| Denis Wirts (Hopkins)
"Biophysical measurements of the microstructural and micromechanical properties of IF networks in vitro and in living cells" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Regulation of IF assembly and dynamics in vivo |
| Discussion Leader: Bishr Omary (VA Med. Centers and
Stanford Univ., Palo Alto) |
| Masaki Inagaki (Aichi Cancer Ctr Res. Inst., Japan)
"Regulation of IFs through phosphorylation" |
| Roy Quinlan (Univ. Dundee, Scotland)
"The stress factor in intermediate filaments" |
| Pedro Salas (Univ. Miami, Miami)
"Are IF domain-organizing scaffolds? The case of the apical pole in simple epithelia" |
| M. Bishr Omary (VA Med. Centers and Stanford Univ., Palo Alto)
"Perspective on Keratin regulation and disease association in simple epithelia" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Function of keratins in epithelia: Beyond scaffolding? |
| Discussion Leader: Thomas Magin (Univ. Bonn, Germany) |
| Thomas Magin (Univ. Bonn, Germany)
"Do keratin mutations predispose to disease beyond the skin?" |
| E. Birgit Lane (Univ. Dundee, Scotland)
"Stress assays and keratin function" |
| Pierre Coulombe (Johns Hopkins Univ., Baltimore)
"Role of keratins during keratinocyte migration" |
| Robert Oshima (Burham Inst, San Diego)
"Apoptosis and Intermediate filaments" |
| Marjana Tomic-Canic (New York Univ., New York)
"Regulation of keratin gene expression in skin" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Issues arising and Poster Discussion |
| Discussion Leaders: Normand Marceau (Univ. Laval, Canada)
& John Eriksson (Univ. Turku, Finland) |
| John Eriksson (Univ. Turku, Finland)
"IFs as targets and modulators of signaling" |
| Normand Marceau (Univ. Laval, Canada)
"Simple epithelium keratins, apoptosis and liver disease" |
| Speakers to be selected from the abstract pool (short talks) |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
