| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | I. BIOPHYSICS OF INTERMEDIATE FILAMENTS |
| 7:30 pm - 7:40 pm | Session Chair: David Parry (Massey University, Palmerston North) |
| Session Vice Chair: Robert Kirmse (German Cancer Research Center, Heidelberg) |
| 7:40 pm - 8:00 pm | Cornerstone Speaker: Paul Janmey (University of Pennsylvania, Philadelphia)
"Softness, strength and self-repair in intermediate filament networks" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Oral Poster Presenter: Robert Kirmse (Session Vice Chair)
"Studying the reaction kinetics of in vitro intermediate filament assembly" |
| 8:25 pm - 8:40 pm | Andreas Hoenger (European Molecular Biology Laboratory, Heidelberg)
"Cryo-electron tomography of vimentin IF´s reveal their protofibrillar substructure" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:00 pm | Laurent Kreplak (Biozentrum Basel, Basel)
"Assembly and nanomechanics of desmin filaments" |
| 9:00 pm - 9:05 pm | Discussion |
| 9:05 pm - 9:20 pm | Karen Ridge (Northwestern University Medical School, Chicago)
"Insights into the cellular mechanisms responsible for hypoxia-induced lung injury" |
| 9:20 pm - 9:25 pm | Discussion |
| 9:25 pm - 9:30 pm | Wrap-up Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | II. LAMIN BIOLOGY AND LAMINOPATHIES |
| 9:00 am - 9:10 am | Session Chair: Gisèle Bonne (Institut de Myologie Paris, Paris) |
| Session Vice Chair: Valérie Decostre (Inserm U582, Paris) |
| 9:10 am - 9:30 am | Cornerstone Speaker: Robert Goldman (Northwestern University, Chicago)
"Nuclear lamins: Building blocks of nuclear architecture" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Oral Poster Presenter: Valérie Decostre (Session Vice Chair)
"N-acetylcysteine treatment of the KI Lmna H222P mouse model of Emery-Dreifuss muscular dystrophy" |
| 9:55 am - 10:10 am | Howard Worman (Columbia University, New York)
"Pathological effects of mutant A-type lamins in heart and adipose tissues" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:40 am | Coffee Break / Group Photo |
| 10:40 am - 10:55 am | Colin Stewart (National Cancer Institute, Frederick)
"The laminopathies: Connections between between the lamina and the extracellular matrix" |
| 10:55 am - 11:05 am | Discussion |
| 11:05 am - 11:20 am | Roland Foisner (Medical University of Vienna, Vienna)
"A role of lamin A - LAP2a complexes in adult stem cell functions: A promising link to laminopathic diseases" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | Georg Krohne (Theodor-Boveri-Institute, Wuerzburg)
"Lamins, nuclear envelope growth and lamin-dependent localization of nuclear envelope proteins" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:10 pm | Stephen Young (University of California, Los Angeles)
"Farnesyltransferase inhibitors and laminopathies" |
| 12:10 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:30 pm | Wrap-up Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | III. INTERMEDIATE FILAMENTS AND ORGANELLE FUNCTION |
| 7:30 pm - 7:35 pm | Session Chair: Carolyn Machamer (Johns Hopkins University, Baltimore) |
| Session Vice Chair: Seyun Kim (Johns Hopkins University, Baltimore) |
| 7:35 pm - 7:50 pm | Cornerstone Speaker: Carolyn Machamer (Johns Hopkins University, Baltimore)
"The Golgi complex in life and death" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:10 pm | Special Overview: Jürgen Schweizer (German Cancer Research Center, Heidelberg)
"New Keratin Nomenclature" |
| 8:10 pm - 8:25 pm | Oral Poster Presenter: Seyun Kim (Session Vice Chair)
"Keratin filaments interact with key components of the translation elongation machinery in vitro and vivo" |
| 8:25 pm - 8:40 pm | Victor Faundez (Emory University School of Medicine, Atlanta)
"Reciprocal interactions between intermediate filaments and the endo-lysosomal sorting machinery" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:00 pm | Thomas Magin (Institute of Physiological Chemistry, Bonn)
"A role for epidermal keratins in melanosome transfer and localization" |
| 9:00 pm - 9:05 pm | Discussion |
| 9:05 pm - 9:20 pm | Yassemi Capetanaki (Foundation for Biomedical Research of the Academy of Athens, Greece)
"Desmin: Multiple roles for myocardial tissue integrity and function" |
| 9:20 pm - 9:25 pm | Discussion |
| 9:25 pm - 9:30 pm | Wrap-up Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | IV. KERATINS AND THEIR DISEASES |
| 9:00 am - 9:10 am | Session Chair: Helmut Denk (Medical University of Graz, Graz) |
| Session Vice Chair: Rudolf Leube (Johannes Gutenberg-University Mainz, Mainz) |
| 9:10 am - 9:30 am | Cornerstone Speaker: Jouni Uitto (Jefferson Medical College, Philadelphia)
"Molecular genetics of the cutaneous basement membrane zone - The paradigm of epidermolysis bullosa" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Oral Poster Presenter: Rudolf Leube (Session Vice Chair)
"Focal adhesion-dependent keratin filament formation" |
| 9:55 am - 10:10 am | Pierre Coulombe (Johns Hopkins University School of Medicine, Baltimore)
"Defining novel functions for keratins in skin epithelia" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Jürgen Schweizer (German Cancer Research Center, Heidelberg)
"Human hair follicle associated keratins" |
| 10:35 am - 10:45 am | Discussion |
| 10:45 am - 11:05 am | Coffee Break |
| 11:05 am - 11:20 am | Birgitte Lane (University of Dundee School of Life Sciences, Dundee)
"Keratin mutations and the consequences of epithelial fragility" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | Pedro Salas (University of Miami, Miami)
"Role of intermediate filaments in epithelial polarization and relationship to keratin mutations" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:10 pm | Masaki Inagaki (Aichi Cancer Center Research Institute, Nagoya)
"Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis" |
| 12:10 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:30 pm | Wrap-up Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | V. INTERMEDIATE FILAMENTS, STRESS AND SIGNALING |
| 7:30 pm - 7:40 pm | Session Chair: Milos Pekny (The Arvid Carlsson Institute for Neuroscience, Goeteborg)
|
| Session Vice Chair: Pavel Strnad (Stanford University, Palo Alto) |
| 7:40 pm - 8:00 pm | Cornerstone Speaker: Tony Hunter (The Salk Institute, La Jolla)
"Protein phosphorylation as a mechanism for signal transduction" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Oral Poster Presenter: Pavel Strnad (Session Vice Chair)
"Transglutaminase is critical for Mallory body inclusion formation during liver injury" |
| 8:25 pm - 8:40 pm | Roy Quinlan (School of Biological and Biomedical Sciences, Durham)
"Alexander Disease and GFAP malfunction" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:00 pm | John Eriksson (University of Turku, Turku)
"Intermediate filaments as signaling organizers" |
| 9:00 pm - 9:05 pm | Discussion |
| 9:05 pm - 9:20 pm | Erica Watson (University of Calgary, Canada)
"Keratin inclusions are toxic to function of trophoblast cells deficient for the Mrj co-chapereone" |
| 9:20 pm - 9:25 pm | Discussion |
| 9:25 pm - 9:30 pm | Wrap-up Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | VI. NEURONAL INTERMEDIATE FILAMENT BIOLOGY AND DISEASES |
| 9:00 am - 9:10 am | Session Chair: Ralph Nixon (Nathan Kline Institute, Orangeburg) |
| Session Vice Chair: Hanna-Mari Pallari (University of Turku, Turku) |
| 9:10 am - 9:30 am | Cornerstone Speaker: Sandra Amor (Biomedical Primate Research Centre Rijswijk, Rijswijk)
"Experimental animal models of autoimmune neurological disorders" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Oral Poster Presenter: Hanna-Mari Pallari (Session Vice Chair)
"Nestin is a high turnover protein with differentiation and assembly state-specific ubiquitylation" |
| 9:55 am - 10:10 am | Anthony Brown (The Ohio State University, Columbus)
"Axonal transport of neurofilaments" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Albee Messing (University of Wisconsin, Madison)
"GFAP mutations and the stress response in Alexander disease" |
| 10:35 am - 10:45 am | Discussion |
| 10:45 am - 11:05 am | Coffee Break |
| 11:05 am - 11:20 am | Jean-Pierre Julien (Laboratory of Molecular Endocrinology, Québec)
"In vivo turnover and axonal transport of neurofilament proteins" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | Michael Garcia (University Missouri-Columbia, Columbia)
"Neurofilament dependent neuronal growth and death" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:10 pm | Harish Pant (National Institute of Neurological Disorders and Stroke, Bethesda)
"The Prolyl-isomerization, neuronal intermediate filament phosphorylation and neurodegeneration" |
| 12:10 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:30 am | Wrap-up Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | VII. INTERMEDIATE FILAMENT ASSOCIATED PROTEINS: FROM BIOLOGY TO DISEASE |
| 7:30 pm - 7:40 pm | Session Chair: Luca Borradori (Hopitaux Universitaires de Geneve, Geneva) |
| Session Vice Chair: Ramona Bhattacharya (Northwestern University, Chicago) |
| 7:40 pm -8:00 pm | Cornerstone Speaker: Tung-Tien (Henry) Sun (NYU Cancer Institute, New York)
"Membrane and cytoskeletal specialization during urothelial differentiation" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Oral Poster Presenter: Ramona Bhattacharya (Session Vice Chair)
"Integrin ß3 Mediates Interaction of Vimentin with Focal Contacts in Endothelial Cells: Functional Implications" |
| 8:25 pm - 8:40 pm | Katherine Wilson (Johns Hopkins University, Baltimore)
"Emerin- and lamin-associated functional complexes" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:00 pm | Kathleen Green (Northwestern University, Chicago)
"Desmosome Assembly in 4D: Dynamic behavior of desmoplakin: plakophilin precursors" |
| 9:00 pm - 9:05 pm | Discussion |
| 9:05 pm - 9:20 pm | Arnoud Sonnenberg (Netherlands Cancer Institute, Amsterdam)
"The actin-binding domain of plectin: a versatile binding element" |
| 9:20 pm - 9:25 pm | Discussion |
| 9:25 pm - 9:30 pm | Wrap-up Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | VIII. INTERMEDIATE FILAMENTS AND TISSUE ARCHITECTURE |
| 9:00 am - 9:10 am | Session Chair: Yosef Gruenbaum (Hebrew University of Jerusalem, Jerusalem) |
| Session Vice Chair: Normand Marceau (Université Lava, Québec) |
| 9:10 am - 9:30 am | Cornerstone Speaker: Angela Christiano (Columbia University, New York)
"A new twist on desmogleins in the hair follicle" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Oral Poster Presenter: Normand Marceau (Session Vice Chair)
"Keratins modulate hepatic cell size, substratum adhesion and G1/S transition Involvement in signaling pathway integration" |
| 9:55 am - 10:10 am | Yosef Gruenbaum (Hebrew University of Jerusalem, Jerusalem)
"Barrier to autointegration factor (BAF): A nuclear lamina protein required for nuclear assembly, chromatin structure and major developmental decisions" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Ron Liem (Columbia University, New York)
"Functional analysis of the different domains of spectraplakins" |
| 10:35 am - 10:45 am | Discussion |
| 10:45 am - 11:05 am | Coffee Break |
| 11:05 am - 11:20 am | Andrew Kowalczyk (Emory University School of Medicine, Atlanta)
"Endocytic trafficking of desmogleins as a mechanism for desmosome disassembly" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | Lars Norlen (Karolinska Institute, Stockholm)
"High-resolution cryo-electron tomography of keratin intermediate filaments in vitreous sections of native human skin" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:10 pm | Ben Szaro (University of Albany, Albany)
"Dynamic association of neurofilament mRNAs with three KH-Domain RNA binding proteins during maturation of the mammalian cerebral cortex" |
| 12:10 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:30 am | Wrap-up Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | IX. GENOMICS AND PROTEOMICS OF INTERMEDIATE FILAMENTS |
| 7:30 pm - 7:40 pm | Session Chair: Larry Gerace (The Scripps Research Institute, La Jolla) |
| Session Vice Chair: Ben Szaro (University at Albany, Albany) |
| 7:40 pm - 8:00 pm | Cornerstone Speaker: Robert Hegele (University of Western Ontario, London (Ontario)
"Phenomic characterization of lamin mutations" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Junko Oshima (University of Washington, Seattle)
"Consequences of LMNA mutation in progeroid syndromes" |
| 8:25 pm - 8:35 pm | Dicussion |
| 8:35 pm - 8:50 pm | Yanmin Yang (Stanford University, Palo Alto)
"IF abnormalities in Giant axonal neuropathy" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:15 pm | Michael Strong (The University of Western Ontario, London (Ontario)
"Perturbations in intermediate filament metabolism in motor neuron degeneration - chicken or the egg?" |
| 9:15 pm - 9:25 pm | Discussion |
| 9:25 pm - 9:30 pm | Meeting Wrap-up: (Bishr Omary, Meeting Chair) |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
