The 2010 Gordon Conference on Intermediate Filaments (IF) will present cutting-edge research on the structure and function of these cytoskeletal and nucleoskeletal components. Representing one of the most diverse gene families in the human genome, over 70 proteins give rise to the several distinct classes of Intermediate Filaments (IFs) that provide mechanical strength to both the cytoplasm and the nucleus. Recent breakthrough research revealing that IF are also involved in signal transduction, cell motility, chromatin organization, and the control of gene expression has reversed the classical view that IF are primarily static, structural proteins. The discovery that mutations in IF genes give rise to a large number of human disorders ranging from skin blistering diseases to pre-mature aging has attracted the attention of both basic scientists and clinicians; and has also sparked interest in defining the underlying mechanisms responsible for a large number of diseases. Every 2 years the Gordon Research Conference on IF brings together scientists from all over the world to discuss their latest results on the cellular, biochemical and structural aspects of the IF family of proteins and how alterations in their normal function lead to a variety of human diseases. The GRC on IF has traditionally fostered a free exchange of ideas, tools and reagents, and has facilitated the establishment of many productive collaborations across disciplines. Space will be reserved for the attendance of young scientists, and all applicants are invited to present posters describing their latest research. In addition, a number of platform presentations will be chosen from the submitted abstracts in order to ensure inclusion of the latest breakthroughs during the formal sessions. Significant time for discussion will be scheduled into the sessions to promote the lively exchange of ideas and to consider alternate interpretations of data presented. Moreover, the conference schedule will allow ample time in the afternoons, after the last evening session and dinner to foster the informal interactions that have been the hallmark of Gordon Conferences.